Pathogenesis of Fungal Keratitis
真菌性角膜炎的发病机制
基本信息
- 批准号:8531490
- 负责人:
- 金额:$ 54.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-02-01 至 2017-04-30
- 项目状态:已结题
- 来源:
- 关键词:Anti-Inflammatory AgentsAnti-inflammatoryAntifungal AgentsAreaAspergillusB-LymphocytesBindingBlindnessBreathingCXC ChemokinesCellsComplicationContact LensesCorneaCorneal StromaDataDendritic CellsDeveloping CountriesDevelopmentDiseaseEnvironmentFibroblastsFundingFusariumGoalsGrowthHarvestHumanHyphaeImmune responseImmunizationIncidenceIncubatedIndiaIndividualInfectionInfiltrationInterleukin-17Interleukin-6InterventionInvadedKeratitisKynurenineLectinLeukocytesMediatingMediator of activation proteinModelingMoldsMusMycosesNADPH OxidaseNatural ImmunityNeutrophil InfiltrationNitrogenOrganismOxygenPainPathogenesisPathway interactionsPatientsPeptide HydrolasesPopulationProductionReactive Oxygen SpeciesReproduction sporesRisk FactorsRoleSeasonsT-LymphocyteTLR4 geneTh1 CellsTissuesTraumaVisionacidic mammalian chitinaseadaptive immunityanterior chamberbasebeta-Chemokinescell typechemokinedectin 1enzyme pathwayfungushuman diseaseinterleukin-23killingsmacrophagemouse dectin-2mouse modelneutrophilnovelocular surfacepathogenperipheral bloodpublic health relevancereceptorresearch studyresponsesubcutaneous
项目摘要
DESCRIPTION (provided by applicant): Pathogenic Fusarium and Aspergillus molds are an important cause of vision loss in the USA and worldwide. Proposed studies will focus on the role of IL-17 producing polymorphonuclear leukocytes (PMN-17) in fungal keratitis by promoting reactive oxygen species production, fungal killing and corneal opacification. Preliminary data show that these previously uncharacterized cells have an important role in the early response to fungal infection, and are present in the corneas of infected individuals. Aim 1 will examine the role of c-type lectins in IL-6 and IL-23 production by macrophages and dendritic cells in response to these pathogens. Aim 2 will examine IL-17 receptor mediated chemokine production in the cornea leading to recruitment of PMN-17 cells, and Aim 3 will examine IL-17 induced NADPH oxidase and kynurenine mediated ROS production by PMN-17 cells. Results of these studies will further our understanding of the role of PMN-17 cells in fungal keratitis and identify novel targets for anti-inflammatory intervention to limit tissue damage in the cornea.
描述(由申请人提供):致病性镰刀菌和曲霉菌是美国和世界范围内视力丧失的重要原因。拟议的研究将集中在IL-17产生的多形核白细胞(PMN-17)在真菌性角膜炎中的作用,通过促进活性氧的产生,真菌杀伤和角膜混浊。初步数据显示,这些以前未表征的细胞在真菌感染的早期反应中起重要作用,并且存在于感染个体的角膜中。目的1将研究C型凝集素在巨噬细胞和树突状细胞产生IL-6和IL-23中的作用,以响应这些病原体。目的2将检查导致PMN-17细胞募集的角膜中IL-17受体介导的趋化因子产生,并且目的3将检查IL-17诱导的NADPH氧化酶和犬尿氨酸介导的PMN-17细胞的ROS产生。这些研究的结果将进一步加深我们对PMN-17细胞在真菌性角膜炎中的作用的理解,并确定抗炎干预的新靶点,以限制角膜组织损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric Pearlman其他文献
Eric Pearlman的其他文献
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{{ truncateString('Eric Pearlman', 18)}}的其他基金
Epigenetic changes to the IL-17 promoter landscape in neutrophils
中性粒细胞中 IL-17 启动子景观的表观遗传变化
- 批准号:
10058179 - 财政年份:2020
- 资助金额:
$ 54.06万 - 项目类别:
Epigenetic changes to the IL-17 promoter landscape in neutrophils
中性粒细胞中 IL-17 启动子景观的表观遗传变化
- 批准号:
10192651 - 财政年份:2020
- 资助金额:
$ 54.06万 - 项目类别:
Innovative Therapeutic Targets for Fungal Keratitis
真菌性角膜炎的创新治疗靶点
- 批准号:
8774001 - 财政年份:2014
- 资助金额:
$ 54.06万 - 项目类别:
Innovative Therapeutic Targets for Fungal Keratitis
真菌性角膜炎的创新治疗靶点
- 批准号:
8926443 - 财政年份:2014
- 资助金额:
$ 54.06万 - 项目类别:
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