Immunology Research Training Grant

摘要 要求在新的培训补助金中支持四个职位，以继续和扩大我们成功的 加州大学欧文分校(UCI)免疫学培训计划。我们共有36位导师 包括初级、中级和高级培训教员，其中包括14名女性和3名市管教员。UCI免疫学 研究人员正在致力于：a)宿主防御和疫苗开发；b)肿瘤免疫学和 免疫疗法；c)神经发生疾病和小胶质细胞生物学；d)慢性疾病和自身免疫；以及 D)合成免疫学。免疫学研究生的主要来源是细胞和 分子生物学(CMB)摄取计划。在2022年，招收了101名学生，其中包括39名城市管理学院 (38.6%)，平均GPA为3.86(与2020年和2021年相近)。有大量的制度 来自研究办公室和加州大学学院研究生部的支持，将提供全额津贴和 第五名学生的学费。我们之前2016-2021年的T32资助了15名学生，其中大多数已经毕业 并在工业界或学术界担任研究职务。埃里克·皮尔曼博士是UCI研究所的主任 他是前一次T32培训拨款的主要研究员。在目前提交的文件中， 皮尔曼博士将担任PI/主任，一位新的教职员工伊万·马拉齐博士将担任联席主任。皮尔曼博士 在培训研究生和管理T32奖学金方面有丰富的经验，Marazzi博士有非常 令人兴奋且资金充足的自身免疫慢性神经退行性疾病研究计划 分子病毒学，包括流感和新冠肺炎。鉴于教职员工出色的培训记录和 在该计划中，我们充分预期UCI免疫学 培训计划将继续为下一代提供出色的教育和职业机会 一代免疫学研究人员。

ABSTRACT Support is requested for four positions in a new training grant to continue and expand our successful Immunology Training Program at the University of California, Irvine (UCI). We have a total of 36 mentors that include junior, mid-level and senior training faculty comprising 14 women and 3 URM faculty. UCI immunology researchers are working on: a) host defense and vaccine development; b) tumor immunology and immunotherapy; c) Neurogenerative disease and microglia biology; d) chronic diseases and autoimmunity; and d) synthetic immunology. The pool of immunology graduate students comes primarily from the Cellular and Molecular Bology (CMB) intake program. In 2022, 101 students were accepted to CMB, including 39 URM (38.6%), and their mean GPA was 3.86 (which was similar to 2020 and 2021). There is substantial institutional support from the Office of Research and from the Graduate Division at UCI, which will provide full stipend and tuition for a 5th student. Our prior T32 from 2016-2021 supported 15 students, most of whom have graduated and are in research positions in industry or academia. Dr. Eric Pearlman is the Director of the UCI Institute for Immunology and was the Prinicipal Investigator of the previous T32 training grant. In the current submission, Dr. Pearlman will be PI/Director, and a new faculty recruit, Dr. Ivan Marazzi, will be co-Director. Dr. Pearlman has extensive experience in training graduate students and running T32 grants, and Dr. Marazzi has a very exciting and well funded research program in autoimmunity chronic neurodegenerative diseases and in molecular virology, including influenza and COVID-19. Given the outsanding training record of faculty and the quality of training grant elibile and URM students in the program, we fully anticipate that the UCI Immunology training program will continue to provide outstanding educational and career opportunities for the next generation of immunology researchers.