PAGE II genotyping at CIDR

CIDR 的 PAGE II 基因分型

• 批准号: 8764216
• 负责人: SONIA DUA
• 金额: $ 208.4万
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8764216
• 关键词: African American; Architecture; Asians; Cardiovascular system; Communities; Complex; Controlled Study; Custom; DNA Sequence; Data; Disease; Epidemiology; European; Funding; Gene Frequency; Genome; Genomics; Genotype; Hawaiian population; Hispanics; Individual; Inherited; Latino; Maps; Metabolic; National Human Genome Research Institute; Participant; Persons; Phase; Phenotype; Population; Quality Control; Research; Research Contracts; Resolution; Resources; SNP genotyping; Structure; Variant; burden of illness; cohort; genome wide association study; population based; trait

Population Architecture using Genomics and Epidemiology (PAGE) is an NHGRI‐funded consortium that aims to examine the population architecture of complex traits, using broad and deep phenotype data from existing and ethnically diverse cohorts. Previously in Phase I (2008‐2013), PAGE performed targeted genotyping of SNPs identified from genome‐wide association studies (GWAS) in ~100,000 European and non‐European descent populations and dense Metabochip genotyping in ~ 60,000 African American, Hispanic/Latino, Asian, and Native Hawaiian participants. The finer level of genotype resolution from Metabochip genotyping facilitated ethnic-specific fine mapping of a wide range of metabolic and cardiovascular traits.

使用基因组学和流行病学的人口结构（PAGE）是一个NHGRI资助的财团，旨在研究复杂性状的人口结构，使用来自现有和种族多样性队列的广泛和深入的表型数据。在之前的I期（2008 - 2013）中，PAGE对从约100，000名欧洲和非欧洲血统人群的全基因组关联研究（GWAS）中鉴定的SNP进行了靶向基因分型，并对约60，000名非洲裔美国人、西班牙裔/拉丁裔、亚洲人和夏威夷原住民参与者进行了密集Metabochip基因分型。来自代谢芯片基因分型的基因型分辨率的更精细水平促进了广泛的代谢和心血管特征的种族特异性精细映射。