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Effect of Waterpipe Tobacco Ingredients on Human Puffing, Exposures and Appeal

水烟烟草成分对人类吸食、暴露和吸引力的影响

基本信息

批准号：
9545730
负责人：
Stephanie S Buehler
金额：
$ 2.99万
依托单位：
BATTELLE CENTERS/PUB HLTH RES & EVALUATN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2019-11-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9545730
关键词：
Acetaldehyde Acrolein Address Affect Analytical Chemistry Apple Artificial Sweeteners Behavior Candy Carcinogens Chemicals Cigarette Data Development Electronic cigarette Exposure to Flavoring Food Form Perception Formaldehyde Fruit Glycerol Human Individual Ingestion Inhalation Label Laboratories Link Liquid substance Mainstreaming Masks Measures Nicotine Participant Particle Size Perception Preparation Prevalence Propylene Glycols Regimen Reporting Research Sensory Smoke Smoker Smoking Standardization Sucrose Taste Perception Time Tobacco Tobacco smoke Tobacco smoking behavior Tobacco use Toxic effect Toxicant exposure Weight Work Youth cigarette smoke cigarette smoking design evidence base experience hedonic hookah human study instrument interest off-label use particle particle exposure psychosocial smoke inhalation sound sugar tobacco products toxicant university student young adult

项目摘要

Project Summary Waterpipe (WP) tobacco smoking has surpassed cigarette smoking and now rivals the electronic cigarette as the most popular tobacco product class in the US among youth. This may be due to the availability of sweet, fruit- and candy-flavored tobaccos that make inhaling tobacco smoke more appealing. It is not clear what is most important in terms of increasing appeal: the smoker's perception of sweetness, or flavor, or both. WP tobacco is unique because of the amounts and identities of its additives and the way that it is smoked. The flavorings and high levels of sweet humectants produce harmful and potentially harmful constituents in the smoke, and are thought to contribute to the direct and indirect harm experienced by users. To define the effects of specific chemical content with respect to sweet perception and likability among users, WP tobacco that differs only in the variables of interest must be used. There is no set of commercially available tobacco brands for which this is true, and thus we propose to manipulate commercial products to properly isolate the important variables. There is an existing data gap surrounding the influence of WP tobacco additives, i.e., sweet humectants and flavorings, on the addictiveness, toxicity, flavor perceptions and appeal of WP smoking. The proposed study uses a crossover human trial, a manipulated WP tobacco prodcut, a validated research grade waterpipe and cutting edge analytical chemistry and psychosocial instruments to systematically investigate the effects of sweet humectant concentration and flavorings on the appeal, puffing behavior, and toxicity of WP tobacco smoking. The purpose of the proposed study is to acquire sound scientific data to inform the development of possible regulatory actions such as identifying and establishing evidenced-based product standards, or maximum thresholds of additives in WP tobacco that must not be exceeded in order for the product to be sold and distributed in the US. This study will address RFA-OD-15-005 questions 3 and 4 by quantifying the impact of WP tobacco additives, such as humectants and flavorants, on human puffing behaviors and HPHC levels in mainstream WP tobacco smoke to address these important data gaps.

项目总结