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The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

45 岁以上的自闭症大脑：解剖学、功能和认知表型

基本信息

批准号：
9418622
负责人：
Ralph-Axel Mueller
金额：
$ 66.99万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-08 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9418622
关键词：
Address Adolescent Adult Affect Age Age-Years Aging Alzheimer&apos s Disease Anatomy Ataxia Autopsy Awareness Behavioral Brain Characteristics Child Clinical Clinical Treatment Cognitive Control Groups Data Development Diffuse Diffusion Magnetic Resonance Imaging Disease Down Syndrome Elderly Episodic memory Equipment and supply inventories Foundations Fragile X Gene Fragile X Syndrome Frequencies Image Imaging Techniques Impairment Individual Inflammatory Response Intervention Investigation Knowledge Life Life Style Link Literature Longevity Longitudinal Studies Magnetic Resonance Imaging Measures Memory Mental disorders Motor Multimodal Imaging Neurocognitive Neurocognitive Deficit Neurodevelopmental Disorder Neurologic Neurologic Deficit Normal Range Outcome Oxidative Stress Participant Pharmaceutical Preparations Phenotype Population Preventive Intervention Probability Public Health Recommendation Research Risk Risk Factors Site Structure Subgroup Symptoms System Testing Thick Thinness Time Tremor age related autism spectrum disorder autistic base behavior change behavior measurement brain behavior cognitive ability cognitive testing developmental disease diffusion weighted experience gray matter imaging modality middle age nervous system disorder prospective public health relevance rate of change recruit relating to nervous system response skills stressor success virtual white matter young adult

项目摘要

DESCRIPTION (provided by applicant): The behavioral and neuroscientific literature on children and adolescents with autism spectrum disorder (ASD) has grown dramatically over the past decades. In contrast, almost nothing is known about ASD later in life. This is problematic in view of preliminary findings suggesting that some older people with ASD may experience accelerated cognitive and neurological decline, combined with extensive evidence of age-related complications and decline in other neurodevelopmental disorders. The present study will be the first systematic investigation of brain anatomy and connectivity in mid to late adulthood in ASD. We will recruit 100 adults with ASD, ages 45-65 years, and 80 matched neurotypical control (NC) participants, and will use anatomical, functional connectivity, and diffusion MRI as well as a battery of sensorimotor and cognitive tests in a longitudinal study, with participants returning after 2.5 years for a second time point. Specific aims will be to examine (1) brain anatomy (cortical thickness and volumes of gray matter structures, white matter, and CSF) and (2) anatomical and functional brain connectivity in adults with ASD compared to NC participants, (3) to characterize cognitive and behavioral abilities, and correlate these skills with brain structure and function, and (4) to create an extensive inventory of variables that may predict long- term neurocognitive success or decline in ASD. Analyses will be performed for a broad range of domains and networks, with some focus on executive, motor, and memory systems. Whereas aims 1-3 will provide a currently unavailable systematic body of evidence on changes in brain and behavior during mid to late adulthood in ASD, aim 4 will have strong prospective translational relevance because identification of brain sites and behavioral measures most likely to predict age-related decline vs. successful aging in ASD will be crucial for the development of preventative interventions.