Colorectal Cancer Survivorship Care in the Veterans Affairs Healthcare System

退伍军人事务医疗系统中的结直肠癌幸存者护理

• 批准号: 8780121
• 负责人: Leah L. Zullig
• 金额: --
• 依托单位: DURHAM VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8780121
• 关键词: Address; Address; Adherence; Adherence; Affect; Affect; Award; Award; Behavior; Behavior; Body mass index; Body mass index; Cancer Control; Cancer Patient; Cancer Patient; Cancer Survivor; Cancer Survivor; Cancer Survivorship; Cancer Survivorship; Cardiovascular system; Cardiovascular system; Caring; Caring; Cause of Death; Cause of Death; Chronic; Chronic; Chronic Disease; Chronic Disease; Clinical; Clinical; Colonoscopy; Colonoscopy; Colorectal Cancer; Colorectal Cancer; Comorbidity; Comorbidity; Data; Data; Data Set; Data Set; Databases; Databases; Diabetes Mellitus; Diabetes Mellitus; Diet; Diet; Disease; Disease; Disease Management; Disease Management; Disease Surveillance; Distress; Distress; Early Diagnosis; Early Diagnosis; Effectiveness; Effectiveness; Epidemiology; Epidemiology; Exercise; Exercise; Foundations; Foundations; Fright; Fright; Guidelines; Guidelines; Health; Health; Health Services; Health Services; Healthcare Systems; Healthcare Systems; Hyperlipidemia; Hyperlipidemia; Hypertension; Hypertension; Intervention; Intervention; Interview; Interview; Knowledge; Knowledge; Life Style; Life Style; Malignant Neoplasms; Malignant Neoplasms; Medical; Medical; Mental Depression; Mental Depression; Mentors; Mentors; Methodology; Methodology; Methods; Methods; Obesity; Obesity; Operative Surgical Procedures; Operative Surgical Procedures; Overweight; Overweight; Participant; Participant; Patients; Patients; Pattern; Pattern; Perception; Perception; Pharmaceutical Preparations; Pharmaceutical Preparations; Population; Population; Practice Management; Predisposition; Predisposition; Prevalence; Prevalence; Provider; Provider; Quality of Care; Quality of Care; Recommendation; Recommendation; Relative (related person); Reporting; Reporting; Research; Research; Research Personnel; Research Personnel; Risk Factors; Risk Factors; Screening for cancer; Second Primary Cancers; Second Primary Cancers; Self Management; Self Management; Self Perception; Severities; Severities; Smoking Status; Smoking Status; Structure; Structure; Surveys; Surveys; Survivors; Survivors; Telephone; Telephone; Testing; Testing; Training; Training; Veterans; Veterans; adherence rate; base; base; cancer recurrence; cancer recurrence; cancer survival; career; career; clinical practice; clinical practice; cohort; cohort; colon cancer patients; comparison group; comparison group; cost; design; design; diet and exercise; diet and exercise; experience; experience; health care service utilization; health care service utilization; improved; improved; medication compliance; medication compliance; multi-component intervention; multi-component intervention; neoplasm registry; neoplasm registry; patient population; patient population; pharmacy benefit; pharmacy benefit; programs; programs; skills; skills; survivorship; survivorship; therapy design; therapy design; time interval; time interval

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is a common, morbid, and often deadly disease in veterans and non- veterans alike. Early detection and better treatment options have increased survival among CRC patients, expanding the need for continuing survivorship care. Among CRC survivors the two leading causes of death are secondary malignancies and comorbid conditions. To mitigate these problems, CRC survivors must adhere to surveillance colonoscopy at guideline-concordant time intervals for early detection of cancer recurrence, medications, and lifestyle recommendations. In the Veterans Affairs (VA) healthcare system, fewer than half of CRC survivors receive a guideline-concordant surveillance colonoscopy within 7-18 months following surgery. There is evidence both within VA and externally suggesting that CRC patients experience distress, fear over cancer recurrence, and depression that encumbers their ability to seek appropriate survivorship care. Little is known about CRC survivors' self- management practices. A better understanding is needed of the national VA CRC survivor cohort, their healthcare utilization patterns, perceived health needs and priorities in order to intervene to facilitate appropriate cancer survivorship care. As an initial step in a long-term veteran-centric research commitment, I propose three projects: Project 1: Utilizing national VA secondary databases, such as the VA Central Cancer Registry, Pharmacy Benefits Manager, and others, I will construct and characterize a national cohort of VA CRC survivors and their self-management behaviors, and define a non-cancer comparison group. Defining the current population of VA CRC survivors is a critical foundation for designing a self-management intervention for this populace. This project addresses: 1) the composition of survivors receiving care in the VA, 2) where are they receiving care, 3) the types of providers coordinating survivorship care, 4) what comorbid conditions affect CRC survivors, 5) body mass index and smoking status, 6) the medical possession ratio of CRC survivors' adherence to prescribed medications; and 7) how these factors compare between CRC survivors and a non-cancer comparison group. Project 2: I will assess VA CRC survivors' perceptions of self-management for survivorship care, including adherence to surveillance colonoscopy, medication adherence, and healthcare utilization. This will require a mixed methods approach encompassing telephone-based quantitative surveys among CRC survivors in VISN 6 and qualitative interviews for a subset of participants. Assessing CRC survivors' perception of self-management is a critical component in designing interventions that motivate patients to action for chronic disease management and cancer surveillance. This patient-reported information will assess perceived: 1) susceptibility and severity of cancer recurrence, 2) susceptibility and severity of common chronic diseases and CVD risk factors such as hypertension, hyperlipidemia, and diabetes, and 3) barriers and benefits of adhering to a survivorship self-management intervention. Project 3: Equipped with information from the first two projects, I will design and pilot-test a self- management intervention to motivate VA CRC survivors' adherence to a survivorship care plan. I will conduct a pilot test with 20 CRC survivors of a self-management intervention targeting increased adherence to: 1) prescription medications for CVD-related risk factors, and 2) surveillance colonoscopy for CRC surveillance. Intervention materials will also address lifestyle choices such as dietary and exercise patterns. This pilot test will elucidate whether the intervention is feasible for CRC survivors and whether short-term medication adherence and intent to undergo colonoscopy be attained. A self- management intervention targeted to this unique patient population will improve survivorship care quality.

描述（由申请人提供）： 结直肠癌（CRC）是一种常见的，病态的，往往是致命的疾病，退伍军人和非退伍军人一样。早期发现和更好的治疗方案增加了CRC患者的生存率，扩大了对持续生存护理的需求。在CRC幸存者中，两个主要死亡原因是继发性恶性肿瘤和合并症。为了缓解这些问题，CRC幸存者必须坚持以与指南一致的时间间隔进行监测结肠镜检查，以早期发现癌症复发，药物治疗和生活方式建议。在退伍军人事务部（VA）医疗保健系统中，不到一半的CRC幸存者在手术后7-18个月内接受了指南一致的监测结肠镜检查。VA和外部都有证据表明CRC患者经历痛苦，对癌症复发的恐惧和抑郁，这使他们有能力寻求适当的生存护理。对CRC幸存者的自我管理实践知之甚少。需要更好地了解国家VA CRC幸存者队列，他们的医疗保健利用模式，感知的健康需求和优先事项，以便进行干预，以促进适当的癌症生存护理。作为长期以退伍军人为中心的研究承诺的第一步，我提出了三个项目：项目1：利用国家VA二级数据库，如VA中央癌症登记处，药房福利经理等，我将构建和表征VA CRC幸存者及其自我管理行为的国家队列，并定义一个非癌症对照组。定义VA CRC幸存者的当前人群是为这一人群设计自我管理干预的关键基础。该项目涉及：1）在VA接受护理的幸存者的组成，2）他们在哪里接受护理，3）协调幸存者护理的提供者类型，4）影响CRC幸存者的共病状况，5）体重指数和吸烟状况，6）CRC幸存者坚持处方药物的医疗占有率;以及7）这些因素如何在CRC幸存者和非癌症对照组之间进行比较。 项目二：我将评估VA CRC幸存者对生存护理自我管理的看法，包括监测结肠镜检查的依从性、药物依从性和医疗保健利用。这将需要一种混合方法，包括在VISN 6中对CRC幸存者进行基于电话的定量调查，并对一部分参与者进行定性访谈。评估CRC幸存者对自我管理的看法是设计干预措施的关键组成部分，这些干预措施激励患者采取行动进行慢性病管理和癌症监测。该患者报告的信息将评估感知的：1）癌症复发的易感性和严重程度，2）常见慢性疾病和CVD风险因素（如高血压、高脂血症和糖尿病）的易感性和严重程度，以及3）坚持生存自我管理干预的障碍和获益。 项目三：从前两个项目的信息配备，我将设计和试点测试自我管理干预，以激励退伍军人事务部CRC幸存者坚持生存护理计划。我将对20名CRC幸存者进行一项试点测试，该自我管理干预旨在增加以下依从性：1）CVD相关风险因素的处方药，2）CRC监测的监测结肠镜检查。干预材料还将涉及生活方式的选择，如饮食和运动模式。该试验将阐明干预措施是否对CRC幸存者可行，以及是否达到短期药物依从性和接受结肠镜检查的意图。针对这一独特患者群体的自我管理干预将提高生存护理质量。