A Genetic Study of Personal Traits that Promote or Inhibit Individual Well-Being

促进或抑制个人福祉的个人特质的遗传学研究

• 批准号: 8470670
• 负责人: Rand Donald Conger
• 金额: $ 43.57万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-23 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8470670
• 关键词: Accounting; Achievement; Address; Adolescent; Affect; Age-Years; Alcohol or Other Drugs use; Archives; Behavior; Behavioral; Biological; Candidate Disease Gene; Case-Control Studies; Cessation of life; Characteristics; Child; Communities; Complex; Crime; DNA; DRD4 gene; Data; Data Analyses; Data Set; Databases; Development; Disinhibition; Emotional; Environment; Environmental Risk Factor; Esthesia; Exons; Failure; Family; Family member; Funding; Generations; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Risk; Genetic Variation; Genome; Genotype; Goals; Health; Health Benefit; Human Development; Individual; Individual Differences; Informal Social Control; Investigation; Life Cycle Stages; Link; Literature; Longevity; Maps; Measurement; Measures; Methods; Modeling; Molecular Genetics; Motivation; Occupational; Outcome; Parents; Participant; Patient Self-Report; Personal Attribute; Personal Satisfaction; Personality; Phenotype; Population; Prevention; Problem behavior; Procedures; Psychopathology; Public Health; Quantitative Genetics; Records; Reporting; Research; Risk; Risk Behaviors; Sample Size; Sampling; Schools; Self Perception; Shapes; Shiners; Siblings; Social Characteristics; Stimulus; Stratification; Stress; Substance abuse problem; Temperament; Testing; Time; Training; Weight; Work; adverse outcome; aged; anti social; base; cohort; design; emotional distress; family structure; gene environment interaction; genetic pedigree; genetic variant; genome wide association study; improved; indexing; informant; insight; interest; meetings; member; novel; offspring; public health relevance; resilience; skills; social; teacher; time use; trait

DESCRIPTION (provided by applicant): This RO1 application seeks five years of support to conduct a molecular genetics study of an existing community-based sample of over 2,400 participants including 500 cohort members (G2 targets), their close- aged siblings, their parents (G1), their romantic partners, and their oldest biological child (G3). The broad objective of this proposal is to evaluate genetic (G), environmental (E), and gene x environment interaction (GxE) effects on a set of core personality attributes that are linked to a host of important developmental outcomes using a weighted, family-based genome-wide association study (GWAS). Specifically, we propose to examine genetic and environmental contributions to the latent traits of Behavioral Disinhibition (BD) and Dispositional Resilience (DR). BD reflects excessive pursuit of exciting appetitive stimuli, disregard for the aversive consequences of risky behaviors, and a tendency to engage in aggressive acts that demonstrate a lack of concern for others. Conversely, DR reflects emotional stability, interpersonal sensitivity, and a self-confident and self-directed orientation to meeting achievement-related challenges. These attributes are present as early as toddlerhood and continue to have important developmental consequences across the life course. In particular these attributes influence whether individuals develop specific competencies and strong interpersonal relationships or whether individuals develop problems that can significantly impair their health and well-being such as involvement with substances, crime, and engaging in risky behaviors. To address these important questions, we will use both existing data from the Family Transitions Project (FTP) as well as genetic information to be collected as part of the proposed study. The FTP was initiated in 1989 when the G2 targets were early adolescents and has continued with annual assessments since that time. The G2 cohort members now average 33 years of age. Each generation in the study has been assessed over a several year period of time using a measurement strategy that is both extensive (i.e., covers multiple domains of personal and social characteristics) and intensive (i.e., employs a multi- informant approach that includes self-reports, other family member reports, teacher reports, ratings by trained observers, school records and public records). Requested funds will be used to collect DNA and genotype the FTP participants. Genotypic information will be combined with the existing archive of contextual and phenotypic data to evaluate genetic and environmental influences on BD and DR. In particular, the unique family structures in this sample include genetically-informative parent-offspring (both G1-G2 and G2-G3) and sibling relationships (G2) which will be ideal for Family-Based Association Test (FBAT) methods.

描述（由申请人提供）：此 RO1 申请寻求五年的支持，对超过 2,400 名参与者的现有社区样本进行分子遗传学研究，其中包括 500 名队列成员（G2 目标）、他们的近亲兄弟姐妹、他们的父母 (G1)、他们的浪漫伴侣和他们最大的亲生孩子 (G3)。该提案的总体目标是使用基于家庭的加权全基因组关联研究 (GWAS) 来评估遗传 (G)、环境 (E) 和基因 x 环境相互作用 (GxE) 对一组核心人格属性的影响，这些核心人格属性与许多重要的发育结果相关。具体来说，我们建议检查遗传和环境对行为去抑制（BD）和性格弹性（DR）的潜在特征的贡献。 BD 反映了过度追求令人兴奋的食欲刺激，无视危险行为的厌恶后果，以及倾向于采取攻击性行为，表明缺乏对他人的关心。相反，DR 反映了情绪稳定性、人际敏感性以及应对与成就相关的挑战的自信和自我导向。这些属性早在幼儿时期就已经存在，并在整个生命过程中继续产生重要的发展后果。特别是，这些属性会影响个人是否发展特定的能力和牢固的人际关系，或者个人是否出现可能严重损害其健康和福祉的问题，例如涉及毒品、犯罪和从事危险行为。 为了解决这些重要问题，我们将使用家庭过渡项目 (FTP) 的现有数据以及作为拟议研究的一部分收集的遗传信息。 FTP 于 1989 年启动，当时 G2 的目标是青少年早期，从那时起一直进行年度评估。 G2 队列成员现在平均年龄 33 岁。研究中的每一代人都使用广泛的（即涵盖个人和社会特征的多个领域）和密集的测量策略（即采用多信息方法，包括自我报告、其他家庭成员报告、教师报告、经过培训的观察员的评分、学校记录和公共记录）对每一代人进行了几年的评估。请求的资金将用于收集 FTP 参与者的 DNA 和基因型。基因型信息将与现有的背景和表型数据档案相结合，以评估遗传和环境对 BD 和 DR 的影响。特别是，该样本中独特的家庭结构包括具有遗传信息的亲子关系（G1-G2 和 G2-G3）和兄弟姐妹关系 (G2)，这对于基于家庭的关联测试 (FBAT) 方法来说是理想的选择。