Biostatistics

生物统计学

• 批准号: 8556456
• 负责人: MICHAEL JOSEPH SCHELL
• 金额: $ 17.22万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8556456
• 关键词: Applied Research; Attention; Biometry; Biostatistics Core; Clinical Trials; Cohort Studies; Databases; Demographic Factors; Development; Faculty; Funding; Link; Modeling; Modification; Participant; Persons; Phase I Clinical Trials; Play; Proteomics; Role; Skin; Skin Cancer; Work; career development; design; experience; follow-up; lifestyle factors; melanoma; novel; programs; research and development

Biostatistics Core B will provide collaborative analytic support to all 4 Moffitt Skin SPORE projects, the other 2 Cores, and the Developmental Research and Career Development Programs. Each project has a faculty biostatistician, selected to maximize the link between their applied research focus and the project. There, will be 4 clinical trials, including phase 1 trials in Projects 2 and 3 that will use a modified Ji design, chosen to provide a richer experience in establishing an MTD. This design, which received extensive discussion and included some modification by the Core B statisticians, will receive special ongoing attention as befits a novel analytical approach. Projects 2 and 4 are both very involved from an analytical perspective and will receive the highest proportions of funding. Project 2 involves extensive proteomics analyses and uses a multi-level Bayesian model developed in part by the project 2 statistician. Project 4 is a case-cohort study involving 1500 participants and 3,000 person-years of follow-up, and includes numerous demographic and lifestyle factors to be examined. In conjunction with Cores A and C, this core will play a vital role in SPORE database development, especially with the clinical trials and case-cohort studies. Biostatistics Core B will be involved in the development of all proposed Developmental Research and Career Development Programs, and will provide analytic support to those that are funded. Working under the direction of faculty biostatisticians are two staff statisticians, who will handle a significant share of the direct statistical programming needed.

生物统计学核心B将为所有4个Moffitt Skin Spore项目，其他2个核心以及发展研究和职业发展计划提供协作分析支持。每个项目都有一个教师生物统计学家，以最大程度地提高其应用研究重点与项目之间的联系。将有4项临床试验，包括项目2和3中的第1阶段试验，这些试验将使用修改后的JI设计，被选为在建立MTD方面提供更丰富的体验。这种设计进行了广泛的讨论，并包括核心B统计学家的一些修改，随着一种新型的分析方法，将受到特殊关注。从分析的角度来看，项目2和4都非常参与，并且将获得最高比例的资金。项目2涉及广泛的蛋白质组学分析，并使用项目2统计学家的一部分开发的多级贝叶斯模型。项目4是一项涉及1500名参与者和3,000人的随访的病例研究，其中包括许多人口统计学和生活方式因素。与核A和C结合使用，该核心将在孢子数据库开发中起着至关重要的作用，尤其是在临床试验和病例研究中。生物统计学核心B将参与所有拟议的发展研究和职业发展计划的开发，并将为资助的人提供分析支持。在教师生物统计学家的指导下工作的是两位员工统计学家，他们将处理所需的直接统计编程中的很大一部分。