Biostatistics Core

生物统计学核心

• 批准号: 9758046
• 负责人: MICHAEL JOSEPH SCHELL
• 金额: $ 0.33万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9758046
• 关键词: Applications Grants; Applied Research; Basic Science; Biometry; Biostatistical Methods; Biostatistics Core; Cancer Center; Cancer Center Support Grant; Certification; Clinical; Clinical Trials; Clinical Trials Design; Collaborations; Conduct Clinical Trials; Core Facility; Data; Development; Ensure; Faculty; Funding; Gene Expression Profiling; Gene Mutation; Goals; Grant; Hour; Individual; Institutional Review Boards; Intervention Studies; Lung; Manuscripts; Mentors; Methods; Modeling; Monitor; Mutation Analysis; Observational Study; Peer Review; Play; Population Sciences; Postdoctoral Fellow; Preparation; Protocols documentation; Publications; Regression Analysis; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Role; Sample Size; Scientist; Services; Skin; Statistical Data Interpretation; Statistical Methods; Supervision; Survival Analysis; Therapeutic Clinical Trial; Training; Training and Education; Work; behavioral study; data resource; design; faculty research; graduate student; investigator training; lectures; meetings; member; novel; phase II trial; programs; research study; tissue resource; tool; trial design

PROJECT SUMMARY The overall goal of the Biostatistics Core (BC) is to provide statistical design and analysis expertise supporting the research efforts of Moffitt Cancer Center (MCC) members. Service begins with analytical design and determination of sample size (e.g., grant and clinical trial submissions), leading to project conduct, monitoring of accumulating research data on active projects, and manuscript development. The BC provides key quantitative analytical results, including tables, figures, and scientific conclusions. Faculty biostatisticians provide education and training in biostatistics, participate actively in the Scientific Review Committees (SRC) and Protocol Review & Monitoring Committee (PRMC), and serve as reviewers for internal grant applications. The BC's Specific Aims are to: 1) Support members by providing high-quality biostatistical design and analysis services; 2) Educate and train investigators on biostatistical resources and tools; and 3) Develop and implement methods for state-of-the-art statistical analyses. The BC also supports the conduct of research through involvement on various oversight committees (e.g., SRC and PRMC). The BC includes nine faculty, seven staff biostatisticians, a Core Facility Manager and a Project Manager. Faculty biostatisticians dedicate 50% to 60% of their effort to the BC and are supported by grant funding, revenue from clinical trials, and institutional support. Staff biostatisticians and the Core Facility Manager are dedicated to the BC and are supported by chargebacks, revenue from clinical trials, and institutional support. BC faculty and staff are involved at all stages of scientific research, from study design to publication of research findings. Most BC efforts involve BC faculty-staff teams. During the past funding cycle, the BC played significant roles in both the Lung and Skin SPORE grants. In addition, BC biostatisticians are part of every investigator-initiated therapeutic clinical trial conducted at MCC. Over the past five years, the BC has supported over 500 clinical trials, research efforts across all five research programs, and research projects that have received SRC approval. In the most recent fiscal year, the BC supported 78 members, with 75% of usage for peer-reviewed-funded members. There are two BC faculty members on each of four SRCs and the PRMC.

项目概要 生物统计学核心（BC）的总体目标是提供统计设计和分析专业知识支持 莫菲特癌症中心 (MCC) 成员的研究成果。服务始于分析设计和 确定样本量（例如拨款和临床试验提交），从而进行项目实施、监测 积累正在进行的项目的研究数据和手稿开发。 BC 提供密钥 定量分析结果，包括表格、图表和科学结论。生物统计学家 提供生物统计学教育和培训，积极参与科学审查委员会（SRC） 和方案审查与监督委员会（PRMC），并担任内部拨款申请的审查员。 BC 的具体目标是： 1) 通过提供高质量的生物统计设计和分析来支持会员 服务； 2) 对调查人员进行生物统计资源和工具方面的教育和培训； 3) 开发和 实施最先进的统计分析方法。 BC 还支持开展研究 通过参与各种监督委员会（例如 SRC 和 PRMC）。 BC 包括九名教员、七名生物统计学家、一名核心设施经理和一名项目经理。 生物统计学家将 50% 到 60% 的精力奉献给 BC，并得到赠款资金的支持， 来自临床试验的收入和机构支持。生物统计学家和核心设施经理是 致力于 BC，并得到退款、临床试验收入和机构支持的支持。 BC 省的教职员工参与科学研究的各个阶段，从研究设计到发表 研究结果。大多数 BC 工作都涉及 BC 教职员工团队。在过去的融资周期中，BC 发挥了 在肺和皮肤 SPORE 拨款中发挥着重要作用。此外，BC 省生物统计学家是每个组织的一部分。 由研究者发起的治疗性临床试验在 MCC 进行。 在过去五年中，BC 已支持了所有五项研究的 500 多项临床试验和研究工作 已获得 SRC 批准的计划和研究项目。在最近的财政年度，BC 支持 78 名成员，其中 75% 的使用量为同行评审资助的成员。 BC省有两名教师 四个 SRC 和 PRMC 的成员。