Identifying and Measuring Depression in Older Cancer Patients

识别和测量老年癌症患者的抑郁症

• 批准号: 8550024
• 负责人: Christian J Nelson
• 金额: $ 17.8万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550024
• 关键词: Address; Adverse effects; Age; Cancer Patient; Cancer Survivor; Cessation of life; Code; Country; DSM-IV; Data; Depressed mood; Depressive disorder; Desire for food; Deterioration; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Dysthymic Disorder; Economic Burden; Elderly; Fatigue; Feeling; Feeling hopeless; Guilt; High Prevalence; Individual; Interview; Link; Major Depressive Disorder; Malignant Neoplasms; Measurement; Measures; Mental Depression; Mental Health; Methods; Minor; Neurobehavioral Manifestations; Oncologist; Pain; Patient Self-Report; Patients; Pattern; Perception; Physical activity; Population; Prevalence; Process; Property; Psychiatrist; Psychologist; Psychometrics; Quality of life; Questionnaires; Reporting; Research; Sampling; Series; Sleep Disorders; Sleep disturbances; Source; Staging; Stomach; Symptoms; Testing; age group; base; cancer diagnosis; cost effective; depressive symptoms; experience; geriatric depression; geriatric mental health; instrument; interest; phrases; pleasure; programs; response; screening; theories; tool; young adult

DESCRIPTION (provided by applicant): The IOM Report states that by 2030, 20% of the population will be over 65. Currently, 60% of cancer diagnoses and 70% of deaths from cancer occur in this age group. Almost two-thirds of cancer survivors in this country are elderly and these percentages will continue to rise for the next 20 to 30 years. Depression is considered one of the top five concerns for the elderly and the prevalence of depressive disorders in older cancer patients ranges from 17-25%. Depression, throughout the spectrum from isolated depressive symptoms to major depressive disorder, is associated with decreased quality of life, deterioration in physical activities, relationship difficulties, caretaker burden, and greater pain. The economic burden of depression in the US has been estimated to be greater than 52 billion dollars a year. Yet, despite the high prevalence rates and deleterious effects of depression, elderly cancer patients are far less likely to be diagnosed with depression (major or minor) than any other age group. One reason for the underdiagnosis of depression in older cancer patients is that these patients may not report classic DSM-IV criteria. Self-report measures of depression are often an efficient and cost-effective way to identify depressive symptoms and make appropriate mental health referrals. However, there is a dearth of psychometric data establishing the validity of existing depression measurement tools in older cancer patients, and because these instruments are typically based on DSM criteria or classic symptoms of depression, it is unlikely that they can effectively assess depressive symptoms in this population. This proposal represents the first step in a program of research geared towards identifying, quantifying, and ultimately alleviating depression in older cancer patients, and will explore how older adults with cancer experience and express depressive symptomatology and develop a self-report scale tailored to this large, but under-recognized, population. The aims of this proposal are: 1) To identify the phenomenology of depression in older cancer patients, 2) To develop a set of indicators to identify depression in older cancer patients and operationalize these indicators in the form of questionnaire items, and 3) To evaluate the preliminary psychometric properties of a self-report measure of depression tailored to the needs of older cancer patients.

描述（由申请人提供）：国际移民组织的报告指出，到2030年，20%的人口将超过65岁。目前，60%的癌症诊断和70%的癌症死亡发生在这个年龄组。在这个国家，几乎三分之二的癌症幸存者是老年人，这些百分比在未来20到30年内将继续上升。抑郁症被认为是老年人最关心的五个问题之一，老年癌症患者中抑郁症的患病率为17- 25%。抑郁症，从孤立的抑郁症状到重度抑郁症，与生活质量下降，体力活动恶化，关系困难，照顾负担和更大的疼痛有关。据估计，美国抑郁症的经济负担每年超过520亿美元。然而，尽管抑郁症的患病率和有害影响很高，但老年癌症患者被诊断患有抑郁症（严重或轻微）的可能性远远低于任何其他年龄组。老年癌症患者抑郁症诊断不足的一个原因是这些患者可能没有报告经典的DSM-IV标准。抑郁症的自我报告措施往往是一种有效和具有成本效益的方式来识别抑郁症状，并作出适当的心理健康转介。然而，缺乏心理测量数据建立现有的抑郁症测量工具在老年癌症患者的有效性，因为这些工具通常是基于DSM标准或抑郁症的经典症状，这是不太可能的，他们可以有效地评估抑郁症状在这一人群中。这项提案代表了一项研究计划的第一步，该计划旨在识别，量化并最终缓解老年癌症患者的抑郁症，并将探索老年癌症患者如何体验和表达抑郁症，并开发一个针对这一庞大但未被充分认识的人群的自我报告量表。该提案的目的是：1）识别老年癌症患者的抑郁现象，2）开发一套指标来识别老年癌症患者的抑郁症，并以问卷项目的形式操作这些指标，以及3）评估针对老年癌症患者需求定制的抑郁症自我报告测量的初步心理测量特性。

项目成果

Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: A randomized controlled trial in patients with advanced cancer.

• DOI: 10.1002/cncr.31539
• 发表时间: 2018-08-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Breitbart W;Pessin H;Rosenfeld B;Applebaum AJ;Lichtenthal WG;Li Y;Saracino RM;Marziliano AM;Masterson M;Tobias K;Fenn N
• 通讯作者: Fenn N

Latent Profile Analyses of Depressive Symptoms in Younger and Older Oncology Patients.

• DOI: 10.1177/1073191118784653
• 发表时间: 2020-10
• 期刊: Assessment
• 影响因子: 3.8
• 作者: Saracino RM;Cham H;Rosenfeld B;J Nelson C
• 通讯作者: J Nelson C

Identification and treatment of depressive disorders in older adults with cancer.

老年癌症患者抑郁症的识别和治疗。

• DOI: 10.1016/j.jgo.2019.02.005
• 发表时间: 2019
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Saracino,RebeccaM;Nelson,ChristianJ
• 通讯作者: Nelson,ChristianJ

Performance of four diagnostic approaches to depression in adults with cancer.

成人癌症患者抑郁症的四种诊断方法的表现。

• DOI: 10.1016/j.genhosppsych.2018.01.006
• 发表时间: 2018
• 期刊: General hospital psychiatry
• 影响因子: 7
• 作者: Saracino,RebeccaM;Rosenfeld,Barry;Nelson,ChristianJ
• 通讯作者: Nelson,ChristianJ