Ventilation Stethoscope using Hyperpolarized Xenon

使用超极化氙气的通气听诊器

• 批准号: 8531346
• 负责人: Mirko I. Hrovat
• 金额: $ 24.92万
• 依托单位: MIRTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531346
• 关键词: Address; Adult; Caring; Cessation of life; Chest; Child; Clinical Trials; Critical Illness; Detection; Development; Device Designs; Devices; Dysbarism; Electronics; Environmental air flow; Equilibrium; Frequencies; Gases; Goals; Housing; Human Volunteers; Individual; Infant; Intensive Care Units; Lasers; Lateral; Life; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Mechanical ventilation; Medical; Methods; Monitor; Morbidity - disease rate; Mus; Nature; Neonatal Intensive Care Units; Newborn Infant; Noble Gases; Noise; Output; Patients; Penetration; Positioning Attribute; Premature Infant; Respiratory Failure; Respiratory distress; Risk; Safety; Secondary to; Side; Signal Transduction; Source; Stethoscopes; Structure; Surface; System; Technology; Titrations; Ventilator; Ventilator-induced lung injury; Volutrauma; Xenon; alveolar type II cell; atelectrauma; base; cost; design; human subject; lung injury; magnetic field; meetings; meter; mortality; portability; premature; pressure; prototype; public health relevance; response; shear stress; surfactant deficiency

DESCRIPTION (provided by applicant): Ventilator Induced Lung Injury (VILI) is a common cause of morbidity and sometimes mortality in critically ill patients with respiratory failure. The types of VILI include barotraumas, volutrauma, atelectrauma, and biotrauma. Thus ventilator setting is a delicate balance between achieving sufficient ventilation but avoiding excessive pressure and overdistension or too little pressure and excessive shear stress when ventilatory units cycle between open and closed. In addition, critically ill patients most often cannot be moved to a CT scanner, which is the traditional method for evaluating adequate ventilation. Thus in order to optimally adjust ventilator settings in an ICU, there is a need for a noninvasive, relatively portable device that can measure regional ventilation. To address this need, in this application, we propose building a portable ventilation stethoscope (VS). The Ventilation Stethoscope is a portable device designed to measure quantitative regional ventilation using the same principles as in Magnetic Resonance Imaging (MRI). Unlike the traditional MRI system, the device is portable, smaller, and performs a measurement of regional ventilation with a single probe (similar to a stethoscope). Thus the VS is a low field (~0.01T) magnetic resonance spectrometer. To enhance sensitivity hyperpolarized 129Xe gas will be injected into the ventilator output. A key aspect of this proposal is the development of a portable continuous flow xenon laser polarizer to produce a steady source of hyperpolarized 129Xe gas. The VS probe will consist of permanent magnets integrated with the rf coil into a single planar structure such that it has a region of magnetic field homogeneity external to the structure itself that is projectd into the lung at a known depth. With this device, we propose to demonstrate the measurement of regional ventilation in healthy adult human volunteers.

描述（由申请人提供）：呼吸机诱发性肺损伤（VILI）是呼吸衰竭危重患者发病和有时死亡的常见原因。的