International Conference on Nausea and Vomiting 2013

描述（由申请人提供）：恶心和呕吐是胃肠道疾病患者常见的高度厌恶的经历，导致食欲下降，生活质量下降，对这些副作用的药物的依从性下降。在了解恶心和呕吐的生物学和治疗方面进展缓慢，部分原因是目前没有集中的科学会议来讨论和合作这些研究课题。目前的R13申请是为了支持将于2013年10月3日至4日在匹兹堡大学举行的关于恶心和呕吐机制的综合科学会议“2013年恶心和呕吐国际会议”。本次会议将极大地促进国家消化疾病委员会的目标，即“了解与胃神经电和/或运动功能障碍以及脑-肠双向相互作用相关的引起恶心和呕吐的有害内脏信号”。会议有四个目标：1)提供一个跨学科交流的论坛，以推进恶心和呕吐的生物学机制研究；2)促进年轻研究者的互动，以展示研究成果，并与实验室和在恶心和呕吐研究领域工作的更多资深研究者建立联系；3)提供一个论坛，让治疗恶心和呕吐患者的科学家和临床医生可以交流信息。4)对恶心和呕吐生物学中尚未解决的主要问题进行概述和讨论，并提供最新的方法。会议将包括五个主要会议：1)个性化医学和遗传学；2)胃轻瘫周期性呕吐综合征；3)前庭和胃肠整合；4)恶心的评估和控制；5)细胞生物学与未来发展方向。演讲者将介绍与胃轻瘫、妊娠、周期性呕吐综合征、晕动病和药物反应（化疗、阿片类镇痛药）相关的恶心和呕吐的前沿研究，包括遗传学、电生理学、神经成像和电子患者报告方法。还将提供青年研究人员参加的科学海报会议。会议记录将发表在同行评议的期刊《实验脑研究》上。与会者主要包括科学家（神经科学、营养学和药理学）、内科医生（胃肠病学、肿瘤学和麻醉学）和其他医疗保健提供者（护士、营养学家）。重点将放在出席的早期调查员，教师和学员，以促进下一代的研究人员。

DESCRIPTION (provided by applicant): Nausea and vomiting are common highly aversive experiences for patients with gastrointestinal disease and result in reductions of appetite, qualit of life, and adherence to medications with these side effects. Progress in understanding the biology and treatment of nausea and vomiting has been slow partly because there is currently no focused scientific meeting to discuss and collaborate on these research topics. The current R13 application is a request to support a comprehensive scientific conference on the mechanisms of nausea and vomiting, "International Conference on Nausea and Vomiting 2013," to be held at University of Pittsburgh (October 3-4, 2013). This conference will substantially contribute to the goal of the National Commission on Digestive Diseases to "understand the noxious visceral signaling causing nausea and vomiting related to gastric neuro-electrical and/or motor dysfunction and the bi-directional brain-gut interactions." There are four objectives of the conference: 1) Provide a forum for cross-disciplinary exchange of ideas to advance research on the biological mechanisms for nausea and vomiting, 2) Foster interactions for young investigators to present research findings and connect with laboratories and more senior investigators working in the field of nausea and vomiting research, 3) Offer a forum where scientists and clinicians who treat patients with nausea and vomiting can exchange information, and 4) Produce an overview and discussion of the major unresolved questions in nausea and vomiting biology and provide the latest methodology. The conference will include five primary sessions: 1) Personalized Medicine and Genetics; 2) Gastroparesis and Cyclic Vomiting Syndrome; 3) Vestibular and Gastrointestinal Integration; 4) Assessment and Control of Nausea; and 5) Cellular Biology and Future Directions. Speakers will present cutting edge research on nausea and vomiting related to gastroparesis, pregnancy, cyclic vomiting syndrome, motion sickness, and drug responses (chemotherapy, opioid analgesics) using genetic, electrophysiological, neuroimaging, and electronic patient reporting approaches. A scientific poster session featuring young investigators will also be provided. The proceedings of the conference will be published in a peer-reviewed journal: Experimental Brain Research. Conference attendees will primarily include scientists (neuroscience, nutrition, and pharmacology), physicians (gastroenterology, oncology, and anesthesiology), and other heathcare providers (nurses, nutritionists). Emphasis will be placed on attendance by early stage investigator faculty and trainees to facilitate the next generation of researchers.