Biology and Control of Nausea and Vomiting 2015

 描述（由申请人提供）： 恶心和呕吐是胃肠道疾病患者常见的高度厌恶的经历，并导致食欲下降，生活质量下降，并坚持使用具有这些副作用的药物。对恶心和呕吐的生物学和治疗的理解进展缓慢，部分原因是目前没有专门的科学会议来讨论和合作这些研究课题。目前的R13应用程序是一个请求，以支持一个全面的科学会议的机制恶心和呕吐，“生物学和控制恶心和呕吐2015年，”将在匹兹堡大学举行（10月23日至24日，2015年）。这次会议将大大有助于国家消化疾病委员会的目标，“了解与胃神经电和/或运动功能障碍有关的引起恶心和呕吐的有害内脏信号以及双向脑肠相互作用。“是次会议有五个目的：一）提供一个跨学科的交流平台，以促进对恶心及呕吐的生物学机制的研究;二）促进早期研究人员的互动，以展示研究成果，并与实验室和从事恶心及呕吐研究的资深研究人员建立联系; 3）提供一个论坛，治疗恶心和呕吐患者的临床医生可以交流信息; 4）概述和讨论恶心和呕吐生物学中尚未解决的主要问题，并提供最新的方法;（5）以同行评审文稿的形式广泛传播会议的结论和共识。会议将包括六个主要会议：1）前驱反应和恶心体征; 2）急性至慢性恶心和呕吐; 3）周期性呕吐综合征研究研讨会; 4）早期研究者研讨会; 5）临床小组讨论;和6）周期性呕吐综合征成人指南会议。演讲者将介绍与胃轻瘫、妊娠、周期性呕吐综合征、晕动病和药物反应（例如，化学疗法）使用遗传学、电生理学、神经成像和患者报告方法。还将举办一次科学海报会议。会议记录将发表在同行评议的期刊：自主神经科学：基础与临床。与会者将包括科学家（神经科学，营养学和药理学），医生（胃肠病学，肿瘤学和麻醉学）和其他医疗保健提供者（护士，营养师）。重点将放在早期研究人员和学员的出席，以促进下一代研究人员。

 DESCRIPTION (provided by applicant): Nausea and vomiting are common highly aversive experiences for patients with gastrointestinal disease and result in reductions of appetite, quality of life, and adherence to medications with these side effects. Progress in understanding the biology and treatment of nausea and vomiting has been slow partly because there is currently no focused scientific meeting to discuss and collaborate on these research topics. The current R13 application is a request to support a comprehensive scientific conference on the mechanisms of nausea and vomiting, "Biology and Control of Nausea and Vomiting 2015," to be held at University of Pittsburgh (October 23-24, 2015). This conference will substantially contribute to the goal of the National Commission on Digestive Diseases to "understand the noxious visceral signaling causing nausea and vomiting related to gastric neuro- electrical and/or motor dysfunction and the bi-directional brain-gut interactions." There are five objectives of the conference: 1) Provide a forum for cross-disciplinary exchange of ideas to advance research on the biological mechanisms for nausea and vomiting; 2) Foster interactions for early-stage investigators to present research findings and connect with laboratories and more senior investigators working in the field of nausea and vomiting research; 3) Offer a forum where clinicians who treat patients with nausea and vomiting can exchange information; 4) Produce an overview and discussion of the major unresolved questions in nausea and vomiting biology and provide the latest methodology; and 5) Broadly disseminate the findings and consensus of the meeting in peer-review manuscripts. The conference will include six primary sessions: 1) Prodromal responses and signs of nausea; 2) Acute-to-chronic nausea and vomiting; 3) Cyclic vomiting syndrome research symposium; 4) Early-stage investigator symposium; 5) Clinical panel discussion; and 6) Cyclic vomiting syndrome adult guidelines session. Speakers will present cutting edge research on nausea and vomiting related to gastroparesis, pregnancy, cyclic vomiting syndrome, motion sickness, and drug responses (e.g., chemotherapy) using genetic, electrophysiological, neuroimaging, and patient reporting approaches. A scientific poster session will also be provided. The proceedings of the conference will be published in a peer- reviewed journal: Autonomic Neuroscience: Basic and Clinical. Conference attendees will include scientists (neuroscience, nutrition, and pharmacology), physicians (gastroenterology, oncology, and anesthesiology), and other heathcare providers (nurses, nutritionists). Emphasis will be placed on attendance by early-stage investigator faculty and trainees to facilitate the next generation of researchers.