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DESCRIPTION (provided by applicant): We propose a systematic proteomic analysis of the human innate immune response to DNA infection coupled with a functional analysis of genes in the network. We focus on the signaling pathways involved in transcription of type I interferon. This project provides a glimpse into the global architecture of antiviral signaling and serves as a resource for further mechanistic analysis of the pathway.
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Interferon-induced IFITM recruitment of ZMPSTE24 blocks viral endocytic entry
  • 批准号:
    9317424
  • 项目类别:
  • 资助金额:
    $51.79万
  • 财政年份:
    2016
  • 负责人:
    MARTIN E DORF
  • 依托单位:
Signaling Networks Controlling Innate Immune Responses to Cytosolic DNA
  • 批准号:
    8283811
  • 项目类别:
  • 资助金额:
    $25.43万
  • 财政年份:
    2012
  • 负责人:
    MARTIN E DORF
  • 依托单位:
Role of TBK1 polyubiquitination in innate antiviral immunity
  • 批准号:
    8108823
  • 项目类别:
  • 资助金额:
    $54.05万
  • 财政年份:
    2011
  • 负责人:
    MARTIN E DORF
  • 依托单位:
Role of TBK1 polyubiquitination in innate antiviral immunity
  • 批准号:
    8280316
  • 项目类别:
  • 资助金额:
    $53.01万
  • 财政年份:
    2011
  • 负责人:
    MARTIN E DORF
  • 依托单位:
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