Signaling Networks Controlling Innate Immune Responses to Cytosolic DNA

控制对细胞质 DNA 的先天免疫反应的信号网络

• 批准号: 8283811
• 负责人: MARTIN E DORF
• 金额: $ 25.43万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8283811
• 关键词: Antiviral Agents; Architecture; B-DNA; Biochemical; Communication; Coupled; DNA; DNA Viruses; Data; Databases; Elements; Family; Gene Silencing; Genes; Genetic Transcription; Human; Immune; Immune response; Immune system; Infection; Infectious Agent; Interferon Activation; Interferon Type I; Interferons; Ligands; Maps; Mediating; Modeling; Molecular; NF-kappa B; Natural Immunity; Pathway Analysis; Pathway interactions; Pattern recognition receptor; Phosphotransferases; Polyubiquitination; Production; Proteins; Proteomics; RNA; Reporter; Resources; Screening procedure; Signal Pathway; Signal Transduction; TBK1 gene; Technology; Tissues; Ubiquitination; Viral; Virus; Virus Diseases; Z-Form DNA; base; cytokine; improved; insight; microbial; novel; organizational structure; pathogen; protein protein interaction; response; sensor; ubiquitin-protein ligase

DESCRIPTION (provided by applicant): We propose a systematic proteomic analysis of the human innate immune response to DNA infection coupled with a functional analysis of genes in the network. We focus on the signaling pathways involved in transcription of type I interferon. This project provides a glimpse into the global architecture of antiviral signaling and serves as a resource for further mechanistic analysis of the pathway. PUBLIC HEALTH RELEVANCE:: The molecular mechanisms involved in regulating innate immune responses to DNA viruses are incompletely understood. We propose a systematic proteomic approach to discover the molecular signaling pathways controlling responses to DNA and DNA viruses.

描述（由申请人提供）：我们建议对人类对DNA感染的先天免疫反应进行系统的蛋白质组学分析，并结合网络中基因的功能分析。我们关注的是参与I型干扰素转录的信号通路。该项目提供了抗病毒信号的全球架构的一瞥，并作为一个