Immunology Physician Scientist

免疫学医师科学家

• 批准号: 8453373
• 负责人: Vincent Robert Bonagura
• 金额: $ 19.99万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453373
• 关键词: Immunology; Physicians; Scientist

DESCRIPTION (provided by applicant): This is a new application for a NIH T32 institutional training grant for training Physician-Scientists in research in immune-mediated disease at The Feinstein Institute for Medical Research within the North Shore LIJ Health System. The large applicant pool (>110 per year for the Allergy and Immunology Residency Training Program) is a source of outstanding physician candidates to train as investigators in the discipline of immunology. These candidates will be competitively selected for appointment to the T32 training program for 3 years of rigorous scientific training. Sixteen established Feinstein faculty investigators have been carefully selected to serve as mentors, based on their excellence in research and teaching. Trainees will enroll in courses at the Elmezzi Graduate School at the Feinstein Institute to acquire a comprehensive fund of knowledge in immunology, genetics and genomics, and the principles of clinical and translational research. They will receive instruction in the preparation and publication of manuscripts, oral presentations at national meetings, preparation of grant applications, and will be assisted in the development of an investigative career. The Feinstein Institute provides a highly interactive critical mass of investigators with diverse trainees comprised of graduate students in the Elmezzi School, medical students (Albert Einstein College of Medicine, NYU), PhD fellows and MD/PhD fellows. Mentors will provide training opportunities in 3 thematic areas: 1) autoimmunity and immune responsiveness, 2) genetic and disease pathogenesis, and 3) inflammation and host response to infection. These mentors provide an in depth and diverse exposure to immune-mediated diseases at the bench in clinical and translational studies. The goal of this T32 training program is to develop immunology physician-scientists who will serve as future investigator leaders, attract and maintain underrepresented minorities, and address the national need for immunology investigators. Its uniqueness is the commitment to and success at transforming clinical practice that characterizes the mentors. RELEVANCE: The decline in physician-scientists is a serious concern. Highly trained individuals completing training programs in immunology are needed to maintain the rapid pace of novel and creative advances in biomedical research that enhance the care of patients with immunologic and inflammatory disorders. These disorders, in aggregate affect over 150 million individuals in the U.S. alone, at a cost of over $100 billion annually. This new training program is committed to successfully respond to this important challenge.

描述（由申请人提供）：这是NIH T32机构培训补助金的新申请，用于在北岸LIJ卫生系统内的Feinstein医学研究所培训免疫介导疾病研究的医生-科学家。庞大的申请人库（每年过敏和免疫学住院医师培训计划>110人）是优秀医生候选人的来源，可以作为免疫学学科的研究人员进行培训。这些候选人将通过竞争性选拔，被任命为T32培训计划的成员，接受为期3年的严格科学培训。16名范斯坦学院的研究人员根据他们在研究和教学方面的卓越表现，被精心挑选为导师。学员将在费恩斯坦研究所的埃尔梅齐研究生院报名参加课程，以获得免疫学，遗传学和基因组学以及临床和转化研究原则的全面知识。他们将接受编写和出版手稿、在国家会议上口头介绍、编写赠款申请的指导，并将在调查职业发展方面得到协助。费恩斯坦研究所提供了一个高度互动的研究人员与不同的受训人员组成的研究生在埃尔梅齐学校，医学生（阿尔伯特爱因斯坦医学院，纽约大学），博士研究员和MD/博士研究员的临界质量。导师将提供3个主题领域的培训机会：1）自身免疫和免疫反应，2）遗传和疾病发病机制，3）炎症和宿主对感染的反应。这些导师在临床和转化研究中提供了对免疫介导疾病的深入和多样化的接触。该T32培训计划的目标是培养免疫学医生科学家，他们将成为未来的研究者领导者，吸引和维持代表性不足的少数民族，并解决国家对免疫学研究者的需求。它的独特之处是致力于并成功地转变临床实践，这是导师的特点。 相关性：医生科学家的减少是一个严重的问题。需要训练有素的个人完成免疫学培训课程，以保持生物医学研究中新颖和创造性进步的快速步伐，从而增强对免疫和炎症性疾病患者的护理。仅在美国，这些疾病总共影响超过1.5亿人，每年的成本超过1000亿美元。这一新的培训计划致力于成功应对这一重要挑战。

项目成果

Obesity shifts house dust mite-induced airway cellular infiltration from eosinophils to macrophages: effects of glucocorticoid treatment.

• DOI: 10.1007/s12026-015-8717-2
• 发表时间: 2015-12
• 期刊: Immunologic research
• 影响因子: 4.4
• 作者: Diaz J;Warren L;Helfner L;Xue X;Chatterjee PK;Gupta M;Solanki MH;Esposito M;Bonagura V;Metz CN
• 通讯作者: Metz CN