HIV and Aging: From the Mitochondria to the Metropolis

描述（由申请人提供）：艾滋病毒和衰老：从线粒体到大都会。 这项R13申请的主要目的是：a）举办3次扩大地理范围的年度会议（南部地区，国家，国际），旨在增加研究并推动艾滋病毒和老龄化科学的发展;以及B）增加专注于该领域差距的各种早期研究人员的渠道。艾滋病研究办公室（OAR）艾滋病毒和老龄化工作组（WG）的调查结果和建议构成了我们会议的基础和框架。我们的目的是吸引和汇集专家，临床医生， 早期阶段的调查人员，以及来自艾滋病毒和老龄化领域的社区领导人。我们希望这些会议能够取得以下成果：a）增加该领域的知识，并提供一个可行的机制，将基础和临床科学发现转化为艾滋病毒/艾滋病感染者（PLWH）社区（即，从“线粒体到大都会”）; B）组建关注临床和研究空白的特殊兴趣小组; c）发展与工作组概述的议程相关的研究人员和研究提案，并通过会议进行操作; d）在广泛的专业人员和场所传播会议内容。这些会议将由执行和科学委员会规划，并有社区的大量代表参加。执行委员会将由埃默里大学CFAR、健康与老龄化中心和阿尔茨海默病研究中心的共同PI领导，并与南方的CFAR和老龄化中心以及艾滋病毒和老龄化CFAR间工作组密切合作。第一次和第三次会议将在亚特兰大，佐治亚州（埃默里大学CFAR）;第二次将在达勒姆，NC（杜克大学CFAR）。目标是：1.主办3次扩大地理范围和覆盖面的年度会议，解决和转化OAR工作组概述的知识和研究差距。所有会议都将包含以下概念的主题：虚弱（包括多发病，功能下降和易患病），慢性炎症，个性化护理和护理影响（包括非正式护理人员）。内容包括基础/生理科学，临床护理和翻译到更广泛的社区。我们将有一个“线粒体到大都会”的主题。具体重点包括：第一年（2014年;区域）：多发病;第二年（2015年;国家）：生物标志物;第三年（2016年;国际）：社会基础设施和照顾特殊人群的问题（妇女，男男性行为者，同性恋，双性恋和变性者，物质使用者，少数民族）。2.创建和建立一个由多学科科学家组成的管道，他们将进行翻译研究，重点是与艾滋病毒和老龄化相关的知识和研究方面的差距。我们将：邀请主要NIH/HRSA/CDC组织的项目官员讨论战略优先事项和资助机会;建立一个艾滋病毒和老龄化listserv，这将提供一个信息和合作的论坛;形成研究特殊兴趣小组，并包括早期研究人员的结构化指导日组件。

DESCRIPTION (provided by applicant): HIV and Aging: From the Mitochondria to the Metropolis. The primary aims of this R13 application are to: a) conduct 3 annual conferences of expanding geographical scope (Southern region, national, international) aimed at increasing research and moving the science in HIV and Aging forward; and b) increase the pipeline of diverse early stage investigators focused on the gaps in this area. The findings and recommendations from the Office of AIDS Research (OAR) Working Group on HIV and Aging (WG) form the foundation and framework for our conferences. Our intent is to attract and bring together experts, clinicians, early stage investigators, and community leaders from the fields of both HIV and Aging. We expect these conferences to lead to the following outcomes: a) increase knowledge in the field and provide a viable mechanism for translating basic and clinical science findings to the community of persons living with HIV/AIDS (PLWH) (i.e., from the "mitochondria to the metropolis"); b) formation of special interest groups that will focus on clinical and research gaps c) development of researchers and research proposals related to the agenda outlined by the WG and operationalized via the conferences; d) dissemination of conference content across a broad range of professionals and venues. The conferences will be planned by Executive and Scientific Boards with substantial representation from the community. The Executive Board will be led by Co- PI's from Emory's CFAR, Center for Health and Aging, and Alzheimer's Disease Research Center with strong collaboration by CFARs and Centers for Aging in the South and the HIV and Aging Inter-CFAR Working Group. The first and third conference will be in Atlanta, GA (Emory University CFAR); the second will be in Durham, NC (Duke University CFAR). The aims are: 1. Host 3 annual conferences of expanding geographical scope and reach that address and translate gaps in knowledge and research outlined by the OAR WG. All conferences will contain threads of the following concepts: Frailty (encompassing multimorbidity, functional decline, and vulnerability to illness), Chronic Inflammation, Personalized Care, and Care Implications (including for informal caregivers). Content ranging from basic/physiologic science, clinical care, and translation to the broader community will be included. We will have a "Mitochondria to Metropolis" theme. Specific foci include: Year 1 (2014; Regional): Multimorbidities; Year 2 (2015; National): Biomarkers; Year 3 (2016; International): Societal Infrastructure and Caregiving Issues with Special Populations (Women, MSM, LGBT, Substance users, Minorities). 2. Create and build a pipeline of diverse multidisciplinary scientists who will conduct translational research focused on the gaps in knowledge and research related to HIV and Aging. We will: Invite program officers from key NIH/HRSA/CDC organizations to discuss strategic priorities and funding opportunities; establish an HIV and Aging listserv which will provide a forum of information and collaboration; form research special interest groups, and include a structured mentoring day component for early stage researchers.