Cytapheresis Of Volunteer Donors (MRI 2003-054)

在这个方案中，志愿者接受两个小时的血细胞分离程序，从单个供体收集大量人类循环白细胞成分（淋巴细胞或单核细胞），供国家老龄研究所实验室研究人员使用。Pheresis包作为匿名包提供给个人合格的研究人员，用于淋巴细胞和单核细胞功能的基础研究以及衰老过程中免疫功能的研究。根据广泛修改的美国血库协会问卷，包括全血细胞计数评估、尿液分析、肝肾功能以及包括HIV和肝炎检测在内的病毒学筛查在内的实验室筛查，将外来感染或其他慢性疾病对实验室研究影响的可能性降至最低。在过去一年中，既定的捐助者人数保持不变，约为70人，进行了221次手术。细胞包提供给个别调查人员用于研究目的。根据过去几年的趋势，一系列实验室对细胞的需求日益增加，预计明年参与者和本议定书程序将继续扩大。

In this protocol, volunteers undergo a two hour cytapheresis procedure for collection of large quantities of human circulating white blood cell components (lymphocytes or monocytes) from single donors for the use of National Institute on Aging laboratory investigators. Pheresis packs are supplied to individual qualified investigators as anonymous packs for use in basic studies of lymphocyte and monocyte function and studies of immune function in the aging process. Based on extensive modified American Bloodbank Association questionaires, laboratory screening including assessment of complete blood counts, urinalysis, liver and renal function as well as virologic screening including HIV and Hepatitis testing, the possibility of influence of extraneous infections or other chronic medical conditions on laboratory studies is minimized. In the course of the last year, the established donor pool has remained constant at approximately 70 participants with 221 procedures performed. Cell packs were supplied to individual investigators for research purposes. Based on trends over the last several years, there is an increasing need for cells by a range of laboratories with expectation for continued expansion of participants as well as procedures in this protocol in the next year.