Regulation of the Reproductive Tract Environment and Prevention of HIV Infection

描述（由申请人提供）：要求支持题为“生殖道粘液环境的激素调节和艾滋病毒感染的预防”的艾滋病毒专题讨论会。本次研讨会将作为ISIR 2013的一部分举行，ISIR 2013是国际生殖免疫学会（ISIR）第12次会议，与美国生殖免疫学会（ASRI）第33次年会于2013年5月28日至6月1日在马萨诸塞州波士顿举行。这次会议由ASRI主办，汇集了世界上最好的生殖免疫学科学家和临床医生。我们提议的艾滋病毒研讨会将使艾滋病毒研究和生殖免疫学的领导者接触，交流信息，找出差距，并探索合作的途径。基于目前关于避孕在HIV感染和传播中的作用的争论，我们研讨会的总体目标是强调外源性和内源性激素以及生殖道粘膜环境在HIV传播中的重要性。具体目标旨在：1）讨论性激素（内源性和外源性）在增强和/或抑制粘膜免疫保护对抗HIV传播中的作用。2)定义生殖道粘膜环境（分泌和组织）在预防或增强HIV获得/HIV感染传播中的作用。3)确定那些因素（微生物组、性传播感染、精液、创伤）在FRT中受到生殖调控，并可能影响对HIV感染的易感性。4)鼓励艾滋病毒研究人员和生殖免疫学家之间的合作活动，特别强调新的研究人员，受训人员和代表性不足的群体。本次艾滋病毒专题讨论会将有一个特别的重点，因为它将为研究生，博士后研究员和代表性不足的群体提供一个独特的机会，与艾滋病毒传播和生殖免疫学领域的领导人会面和互动。该应用程序支持ISIR和ASRI的长期目标，即促进初级研究人员的培训。本次会议的另一个目标是让每位受邀演讲者提交一篇关于其会议演讲主题的评论/文章，以便在美国生殖免疫学杂志特刊上发表。我们提议的研讨会将通过了解生殖器粘膜与艾滋病毒之间的相互作用，以更好地促进抑制艾滋病毒的传播和获得，从而加强杀微生物剂，PrEP和疫苗预防策略。

DESCRIPTION (provided by applicant): Support for the HIV Symposium entitled "Hormone Regulation of the Mucosal Environment in the Reproductive Tract and the Prevention of HIV Infection" is requested. This Symposium will take place as a part of ISIR2013 which is the 12th Meeting of the International Society for Immunology of Reproduction (ISIR) conjoined with the 33rd annual Meeting of American Society for Reproductive Immunology (ASRI) on May 28 - June 1, 2013 in Boston, MA. Hosted by ASRI, this conference brings together the world's best scientists and clinicians in reproductive immunology. Our proposed HIV Symposium will bring leaders in HIV research and reproductive immunology into contact to exchange information, identify gaps, and explore avenues of collaboration. Based on the current controversy with regard to the role of contraception in HIV acquisition and transmission, the overall objective of our workshop is to emphasize the importance of exogenous and endogenous hormones and the mucosal environment of the reproductive tract in HIV transmission. Specific Aims are designed to: 1) Discuss the role of sex hormones (endogenous and exogenous) in enhancing and/or suppressing mucosal immune protection against HIV transmission. 2) Define the role of the mucosal environment (secreted and tissue) in the reproductive tract in preventing or enhancing HIV acquisition/transmission of HIV infection. 3) Identify those factors (microbiome, STIs, semen, trauma) that are hormonally modulated in the FRT and may influence susceptibility to HIV infection. 4) Encourage collaborative activity between HIV researchers and reproductive immunologists with special emphasis on new investigators, trainees and under-represented groups. This HIV Symposium will have a special focus in that it will provide a unique opportunity for graduate students, postdoctoral fellows and under-represented groups to meet and interact with leaders in the field of HIV transmission and reproductive immunology. This application supports a long-term goal of the ISIR and ASRI, which is to foster training of junior investigators An additional goal of this conference is to have each of the invited speakers submit a review/article on the subject of their conference presentation for publication in a Special Issue o the American Journal of Reproductive Immunology. Our proposed Symposium will lead to enhanced microbicide, PrEP and vaccine prevention strategies by understanding the interactions between the genital mucosa and HIV to better promote inhibition of HIV transmission and acquisition.