Advanced Imaging for Glaucoma Study Optic Disc Reading Center

描述(申请人提供)：青光眼高级成像研究(AIGS)是一项前瞻性的多中心纵向观察研究，旨在测试先进成像技术的能力：扫描激光偏振(SLP)、扫描激光断层扫描(SLT)、时间域光学相干断层扫描(TD-OCT)、傅立叶域光学相干断层扫描(FD-OCT)和多普勒傅里叶域光学相干断层扫描视网膜血流(CDOCT)，以提高青光眼早期检测和预测青光眼视野缺陷的发展。迈阿密大学米勒医学院/巴斯科姆·帕尔默眼科研究所(BPEI)、匹兹堡大学医学中心(UPMC)和南加州大学/多尼眼科研究所(USC)都是临床中心。协调中心和主席办公室设在俄勒冈健康与科学大学(OHSU)。项目主席David Huang博士要求前青光眼治疗研究和协作初始青光眼治疗研究视盘阅读中心主任Richard Parrish博士建立青光眼高级成像-视盘阅读中心(AIGs-ODRC)。其理论基础是基于三个临床中心的临床眼科医生进行的非均匀和无掩蔽的视盘评估结果。我们建议通过对现有AIGS立体照片的评估来实现五个具体目标：提供统一的遮盖并排的视盘特征读数，并确定视盘转化和进展终点；比较临床中心对视盘转化和进展的测定与ODRC的结果；比较先进的成像方式与视盘测定；将先进的成像方式与视野和视盘测定相结合；创建可供研究人员使用的视盘照片的数字数据库。结果来自于 AIGs-ODRC立体视盘评估是一种金标准、低成本、定性的技术，将与更昂贵和更定量的先进成像技术所获得的结果进行比较。

DESCRIPTION (provided by applicant): The Advanced Imaging for Glaucoma Study (AIGS), a prospective longitudinal multicenter observational study was designed to test the ability of advanced imaging technologies: scanning laser polarimetry (SLP), scanning laser tomography (SLT), time domain optical coherence tomography (TD-OCT), Fourier domain optical coherence tomography (FD-OCT), and Doppler Fourier domain optical coherence tomography measurement of retinal blood flow (Doppler OCT) to improve the early detection of glaucoma and to predict the development of glaucomatous visual field defects. The University of Miami Miller School of Medicine/Bascom Palmer Eye Institute (BPEI), University of Pittsburgh Medical Center (UPMC), and the University of Southern California/Doheny Eye Institute (USC) are Clinical Centers. The Coordinating Center and Chairman's Office are located at Oregon Health and Science University (OHSU). Dr. David Huang, Project Chairman, asked Dr. Richard Parrish, former director of the Ocular Hypertension Treatment Study and Collaborative Initial Glaucoma Treatment Study Optic Disc Reading Centers to establish an Advanced Imaging for Glaucoma-Optic Disc Reading Center (AIGS-ODRC). The rationale was based on the results of non-uniform and unmasked optic disc assessments that were performed by clinical ophthalmologists at the three clinical centers. We propose to achieve five specific aims from assessment of existing AIGS stereoscopic photographs: provide uniform masked side by side readings of optic disc characteristics and determine optic disc conversion and progression endpoints~ compare the clinical centers' determination of optic disc conversion and progression with that of the ODRC~ compare advanced imaging modalities to optic disc determinations~ compare advanced imaging modalities to visual field combined with optic disc determinations~ create a digital database of optic disc photographs available to researchers. The results from the AIGS-ODRC stereoscopic optic disc assessment, a gold standard, low- cost, qualitative technique will be compared with the results obtained with the more expensive and quantitative advanced imaging technologies.