Robotic Ultrasound Image Guidance System for Radiation Therapy

用于放射治疗的机器人超声图像引导系统

• 批准号: 8550030
• 负责人: Dimitre Hristov Hristov
• 金额: $ 7.33万
• 依托单位: SONITRACK SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550030
• 关键词: 4D Imaging; Abdomen; Accounting; Address; Adoption; Algorithms; Anatomy; Breathing; Businesses; Cancer Patient; Clinical; Computer software; Data; Detection; Disease Management; Dose; Emerging Technologies; Ensure; Environment; External Beam Radiation Therapy; Grant; Health; Hybrids; Image; Implant; Knowledge; Lesion; Life; Light; Linear Accelerator Radiotherapy Systems; Magnetic Resonance Imaging; Malignant neoplasm of abdomen; Malignant neoplasm of liver; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measures; Methods; Mission; Modification; Motion; Movement; Outcome; Patient Schedules; Patients; Pelvic Cancer; Periodicals; Phase; Positioning Attribute; Posture; Process; Radiation; Radiation therapy; Regimen; Renal carcinoma; Research; Robotics; Site; Structure; System; Technology; Technology Transfer; Time; Tissues; Toxic effect; Treatment Protocols; Treatment outcome; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Vision; Work; base; burden of illness; clinical risk; commercial application; commercialization; design; image registration; improved; kinematics; minimally invasive; molecular imaging; novel; novel strategies; radiation effect; simulation; soft tissue; therapy design; treatment planning; trend; tumor

DESCRIPTION (provided by applicant): External Beam Radiation Therapy (EBRT) is used in the disease management of more than half of all cancer patients worldwide. In order to advance the field of EBRT and improve treatment outcomes, highly conformal, potent ablative doses must be delivered to maximize local tumor control and minimize toxicity to surrounding healthy tissue. Random and quasi-periodical anatomy motion during beam delivery poses a fundamental threat to realizing such conformity, and thus restricts the curative potential of EBRT. Existing and emerging technologies for localizing abdominal targets during beam delivery employ tracking of implanted fiducial markers, tracking of external surrogates, or guidance via magnetic resonance images. However, these technologies cannot provide real-time, volumetric, non-invasive, markerless soft-tissue image guidance capabilities to existing radiation delivery platforms. Thus a significant scientific and commercial opportunity exists to improve the technical capability and clinical outcomes of EBRT. Our vision is to realize this opportunity by pursuing a novel EBRT image guidance approach combining real-time volumetric (4D) ultrasound (US) with robotic technology. In the envisaged product, soft-tissue images of target anatomy are continuously obtained using a customized, minimally-invasive robotic manipulator designed to control the position and force of a 4D US probe against the patient. Before and during treatment, tissue displacements are tracked in spatially localized US images and used to guide precise patient positioning and EBRT delivery to the target. In this Phase I Small Business Technology Transfer grant, SoniTrack Systems proposes to establish the commercial feasibility of such a product by: (1) demonstrating the robustness of the robotic 4D US system for imaging abdominal and pelvic cancer patients; (2) demonstrating two effective strategies to account for image guidance system hardware in radiation treatment designs; and (3) demonstrating real-time 3D tracking of target sites with multi-plane and volumetric US imaging. Accomplishment of these objectives will remove the main technological and clinical risks related to the proposed product. Commercialization of the product by SoniTrack can transform the radiation therapy field by enabling treatments that are truly adaptive to the continuous changes of internal soft-tissue anatomy during radiation beam delivery.

描述（由申请人提供）： 体外放射治疗 (EBRT) 用于全球一半以上癌症患者的疾病管理。为了推进 EBRT 领域的发展并改善治疗结果，必须提供高度适形、有效的消融剂量，以最大限度地控制局部肿瘤并最大限度地减少对周围健康组织的毒性。光束传输过程中的随机和准周期性解剖运动对实现这种一致性构成了根本威胁，从而限制了 EBRT 的治疗潜力。在光束传输过程中定位腹部目标的现有和新兴技术采用跟踪植入的基准标记、跟踪外部替代物或通过磁共振图像进行引导。然而，这些技术无法为现有的辐射传输平台提供实时、体积、非侵入性、无标记的软组织图像引导功能。因此，存在着提高 EBRT 技术能力和临床结果的重要科学和商业机会。我们的愿景是通过追求一种新颖的 EBRT 图像引导方法，将实时体积 (4D) 超声（US）与机器人技术相结合来实现这一机会。在设想的产品中，使用定制的微创机器人操纵器连续获得目标解剖结构的软组织图像，该操纵器旨在控制 4D US 探头对患者的位置和力。在治疗之前和治疗期间，在空间局部超声图像中跟踪组织位移，并用于指导精确的患者定位和 EBRT 递送至目标。在第一阶段小型企业技术转让资助中，SoniTrack Systems 建议通过以下方式建立此类产品的商业可行性：(1) 展示机器人 4D US 系统对腹部和盆腔癌患者成像的稳健性； (2) 展示两种有效策略来考虑放射治疗设计中的图像引导系统硬件； (3) 通过多平面和体积 US 成像演示目标部位的实时 3D 跟踪。这些目标的实现将消除与拟议产品相关的主要技术和临床风险。 SoniTrack 该产品的商业化可以通过实现真正适应放射束传输期间内部软组织解剖结构的连续变化的治疗来改变放射治疗领域。