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Intersection of NER and DNA crosslink repair processes

NER 和 DNA 交联修复过程的交叉点

基本信息

批准号：
8528940
负责人：
Bennett Van Houten
金额：
$ 0.8万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8528940
关键词：
Address Aromatic Polycyclic Hydrocarbons Automobile Driving Biological Factors Carcinogens Cell Death Cells Cisplatin Cockayne Syndrome Complex Congenital Abnormality Country Coupled DNA DNA Damage DNA Repair DNA Repair Enzymes DNA Repair Pathway DNA Structure DNA crosslink DNA lesion DNA-Directed DNA Polymerase Data Defect Development Disease Educational workshop Environmental Health Environmental Risk Factor Enzymes European Union Excision Fanconi&apos s Anemia Ficusin Funding Gene Mutation Genes Genome Genomics Goals Growth Hereditary Disease Human Joints Lesion Lipids Malignant Neoplasms Malignant Squamous Cell Neoplasm Mechlorethamine Mentors Mentorship Mitomycins Mutation Nerve Degeneration Nucleotide Excision Repair Pancytopenia Pathway interactions Patients Play Polymerase Post-Translational Protein Processing Predisposition Premature aging syndrome Process Proteins Psoralens Research Research Infrastructure Risk Role Science Scientist Set protein Signal Transduction Signaling Protein Site Skin Cancer Slovakia Sorting - Cell Movement Structure Syndrome Technical Expertise Technology Toxic Environmental Substances Trichothiodystrophy UV induced Ubiquitination United States Woman Work Xeroderma Pigmentosum abstracting adduct career development chemotherapeutic agent crosslink disease phenotype genetic analysis human disease killings lectures man meetings nuclease oxidation protein function protein protein interaction public health relevance repaired tool

项目摘要

DESCRIPTION (provided by applicant): The purpose of this workshop is to bring together scientists from the European Union (EU) and US to discuss our current understanding of how protein machines assemble and sort through genomic DNA to identify specific damaged sites which are repaired through the two critical repair pathways: nucleotide excision repair (NER) or interstrand crosslink repair (ICR). Several of the enzymes perform dual functions in both pathways, thus combining these two topics in one meeting provides tremendous synergy and is the unique feature of this workshop. Many endogenous agents, environmental toxicants and chemotherapeutic agents cause DNA damage that is repaired through these two mechanisms. The importance of the repair pathways acting on these forms of damage is underscored by the fact that their loss or dysregulation is associated with a variety of devastating heritable human conditions including cancer, neurodegeneration, premature aging and severe developmental abnormalities. The workshop will move from molecules to man and include a discussion of the disease syndromes associated with poor repair of these damage substrates. The main objective of this workshop is to fully address the problem of damage recognition and processing involved in nucleotide excision repair and interstrand crosslink repair by generating an understanding of the current state of the science and then articulate where the science will go once current technical and scientific hurdles are overcome. The main goals of this workshop are to: 1) highlight the state of the science and current technologies being used to study this problem; 2) exchange ideas between scientists in the EU and US; and 3) provide a forum that allows scientists in the local region an opportunity to meet and engage with scientists from the EU and US who are driving the field.

描述(申请人提供)：本次研讨会的目的是将来自欧盟(EU)和美国的科学家聚集在一起，讨论我们目前对蛋白质机器如何组装和分类基因组DNA以确定通过两条关键修复途径修复的特定受损部位的理解：核苷酸切除修复(NER)或链间交联修复(ICR)。几种酶在两种途径上都具有双重功能，因此在一次会议上将这两个主题结合起来提供了巨大的协同效应，这也是本次研讨会的独特之处。许多内源性物质、环境毒物和化疗药物导致DNA损伤，而DNA损伤是通过这两种机制修复的。作用于这些形式的损伤的修复途径的重要性被以下事实所强调：它们的丢失或调节失调与各种毁灭性的可遗传人类疾病有关，包括癌症、神经退化、过早衰老和严重的发育异常。研讨会将从分子转移到人类，并包括与这些受损底物修复不良相关的疾病综合征的讨论。该讲习班的主要目的是通过了解科学的现状，阐明一旦克服当前的技术和科学障碍，科学将何去何从，从而全面解决核苷酸切除修复和链间交联修复所涉及的损伤识别和处理问题。该研讨会的主要目标是：1)突出研究这一问题的科学和当前技术的现状；2)在欧盟和美国的科学家之间交流思想；3)提供一个论坛，让当地的科学家有机会与推动这一领域的欧盟和美国的科学家见面和接触。