Intersection of NER and DNA crosslink repair processes

描述（由申请人提供）：本次研讨会的目的是汇集来自欧盟（EU）和美国的科学家，讨论我们目前对蛋白质机器如何通过基因组DNA组装和排序以识别通过两种关键修复途径修复的特定受损位点的理解：核苷酸切除修复（NER）或链间交联修复（ICR）。几种酶在两种途径中发挥双重功能，因此将这两个主题结合在一次会议中提供了巨大的协同作用，这是本次研讨会的独特之处。许多内源性物质、环境毒物和化疗剂引起DNA损伤，通过这两种机制修复。作用于这些形式的损伤的修复途径的重要性被以下事实所强调，即它们的损失或失调与各种破坏性的可遗传的人类病症相关，包括癌症、神经变性、过早衰老和严重的发育异常。研讨会将从分子转移到人，并包括与这些损伤基质修复不良相关的疾病综合征的讨论。本次研讨会的主要目标是充分解决损伤识别和处理涉及核苷酸切除修复和链间交联修复的问题，通过产生对科学现状的理解，然后阐明一旦克服当前的技术和科学障碍，科学将走向何方。本次研讨会的主要目标是：1）突出科学和当前技术的状态，用于研究这一问题; 2）在欧盟和美国的科学家之间交流思想;和3）提供一个论坛，让当地的科学家有机会与来自欧盟和美国的科学家会面和参与谁是驱动该领域。

DESCRIPTION (provided by applicant): The purpose of this workshop is to bring together scientists from the European Union (EU) and US to discuss our current understanding of how protein machines assemble and sort through genomic DNA to identify specific damaged sites which are repaired through the two critical repair pathways: nucleotide excision repair (NER) or interstrand crosslink repair (ICR). Several of the enzymes perform dual functions in both pathways, thus combining these two topics in one meeting provides tremendous synergy and is the unique feature of this workshop. Many endogenous agents, environmental toxicants and chemotherapeutic agents cause DNA damage that is repaired through these two mechanisms. The importance of the repair pathways acting on these forms of damage is underscored by the fact that their loss or dysregulation is associated with a variety of devastating heritable human conditions including cancer, neurodegeneration, premature aging and severe developmental abnormalities. The workshop will move from molecules to man and include a discussion of the disease syndromes associated with poor repair of these damage substrates. The main objective of this workshop is to fully address the problem of damage recognition and processing involved in nucleotide excision repair and interstrand crosslink repair by generating an understanding of the current state of the science and then articulate where the science will go once current technical and scientific hurdles are overcome. The main goals of this workshop are to: 1) highlight the state of the science and current technologies being used to study this problem; 2) exchange ideas between scientists in the EU and US; and 3) provide a forum that allows scientists in the local region an opportunity to meet and engage with scientists from the EU and US who are driving the field.