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Daily Functioning, Cognition, and Caregiver Burden in MCI Patients

MCI 患者的日常功能、认知和护理负担

基本信息

批准号：
8500372
负责人：
Laleh Jill Razani
金额：
$ 10.39万
依托单位：
CALIFORNIA STATE UNIVERSITY NORTHRIDGE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8500372
关键词：
Activities of Daily Living Address Affect Alzheimer&apos s Disease Area Attention Awareness Caregiver Burden Caregivers Clinical Cognition Cognitive Cognitive deficits Complex Data Data Collection Databases Dementia Development Diagnosis Diagnostic Diagnostics Research Disease Economics Educational process of instructing Elderly Emotional Exhibits Exposure to Family Feeling Frontotemporal Dementia Functional disorder Funding Funding Mechanisms Future Grant Hispanics Impaired cognition Impairment Individual Institution Intervention Judgment Knowledge Laboratories Lead Literature Manuscripts Measures Memory Memory impairment Mentorship Minority Nature Neuropsychological Tests Patients Pattern Peer Review Performance Preparation Publications Publishing Questionnaires Recruitment Activity Relative (related person)Reporting Research Research Personnel Severities Staging Stress Students Testing Time United States National Institutes of Health Vascular Dementia abstracting base care burden cognitive function daily functioning disability ethnic minority population experience follow-up functional decline functional disability informant information processing instrument instrumental activity of daily living interest longitudinal design mild cognitive impairment neuropsychological normal aging processing speed professor programs psychologic psychological distress social treatment planning undergraduate student

项目摘要

Individuals at the very early stages of dementia (most often Alzheimer's disease) are referred to as having mild cognitive impairment (MCI). However, concrete clinical diagnostic criteria have not yet been established because cognitive and daily functional impairments are not yet well characterized in individuals with MCI. The current research criteria states that individuals with MCI must exhibit memory impairment beyond that of normal aging and maintain relatively preserved daily functional abilities (Petersen, 2004). Yet, recent research indicates that MCI patients are likely to experience subtle functional impairments (Farias et al., 2009; Pernesczky et al., 2006a). The problem is that most of the studies assessing daily functioning have used either cognitive rating forms or self- or informant-rated instrumental activities of daily living which can lead to biased results (Albert et al., 1999; Wadley et al., 2003; Razani et al., 2007). Additionally, very little attention has been paid to caregiver's of MCI individuals, given that there is an assumption that individuals with MCI do not require assistance in their daily activities. Thus, the aims of the present study are. 1) to characterize daily functioning in MCI individuals using a performance-based measure and to examine how neuropsychological impairment affects functional ability in MCI patients relative to those with diagnosed dementia, 2) to characterize how neuropsychological and functional impairments affect caregivers of MCI individuals, and 3) to assess whether the rate of cognitive decline can predict the rate of functional decline in MCI individuals and the rate of increased burden for their caregivers. Forty individuals with MCI (using the current research diagnostic criteria for MCI) will be recruited and administered a clinical neuropsychological test battery that includes tests of memory, attention, abstract reasoning, and information processing speed, as well as a performance-based functional task. The performance of the MCI individuals will be compared to a database of individuals with dementia (Alzhiemer's disease, Frontotemporal dementia, and Vascular dementia) and normal controls. Additionally, next-of-kin caregivers will be administered a set of questionnaires in order to assess the level of burden and psychological distress experienced. Patients and caregivers will be administered tests at baseline and 1-year follow-up periods. The functional abilities of the groups will be compared, the degree to which neuropsychological test scores predict daily functioning will be examined, and finally decline in cognitive and functional abilities over a 1-year period will be assessed. The results will better characterize degree, type and severity of deficits experienced by MCI individuals and their caregivers, which will assist with refining the diagnostic criteria for MCI and lead to better treatment planning for patients and their families.