CARDIOMETABOLIC DISEASE & RISK FACTORS AMONG OLDER ADULTS IN SUB-SAHARAN AFRICA

心脏代谢疾病

• 批准号: 8589166
• 负责人: THOMAS A GAZIANO
• 金额: $ 2.77万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8589166
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Age; Aging; Ankle; Area; Autopsy; Behavioral; Biological; Biological Assay; Biological Factors; Biological Markers; Blood Pressure; Blood Vessels; Body mass index; C-reactive protein; Cardiac; Cardiovascular Diseases; Caring; Cause of Death; Censuses; Cessation of life; Chronic; Clinical; Clinical Markers; Clinics and Hospitals; Cohort Studies; Collection; Communicable Diseases; Communities; Complex; Country; Data; Demographic Transitions; Development; Diabetes Mellitus; Disease; Echocardiography; Economic Factors; Economics; Elderly; Enrollment; Environmental Risk Factor; Epidemiology; Event; Fasting; Future; Geographic Locations; Ghana; Goals; HIV; HIV Infections; Health; Health Policy; Health Promotion; Health Status; Health system; Improve Access; Incidence; Income; Individual; Inflammation; Inflammatory; Instruction; Intervention; Lead; Life; Link; Lipids; Longitudinal Studies; Measurement; Measures; Metabolic Diseases; Modeling; Morbidity - disease rate; Outcome; Participant; Patient Self-Report; Pattern; Peripheral Vascular Diseases; Persons; Phase; Physical Function; Physical assessment; Population; Prevalence; Reporting; Risk; Risk Factors; Risk Marker; Running; Rural; Sampling; Services; Site; Smoking; Social Health Services; Social Network; Social Policies; Socioeconomic Factors; South Africa; Staging; Surveys; System; Systems Development; Tanzania; Testing; Time; Ultrasonography; Venous; Woman; Work; acute stroke; advanced disease; aged; base; cardiovascular disorder risk; cognitive function; cohort; comparative; cost; disorder risk; experience; follow-up; high risk; indexing; inflammatory marker; men; migration; modifiable risk; mortality; novel; novel marker; screening; social; tool; trend

Project 2: Cardiometabolic Disease and Risk Factors Among Older Adults in Sub-Saharan Africa Cardiovascular disease (CVD) has become the leading cause of death globally as a result of epidemiologic, social, and economic transitions globally. These transitions are at a relatively early stage in Sub-Saharan Africa (SSA), with the countries under study at different stages and experiencing contrasting trajectories. The purpose of this project is to establish cohorts of persons aged 50 and over in rural South Africa, Ghana, and Tanzania and, in doing so, characterize the changing rates, causes, and consequences of cardiometabolic disorders among older people in African settings undergoing demographic transition. Reliable data on baseline levels of chronic cardiometabolic disease (CMD) such as CVD and diabetes in older ages are extremely limited in rural SSA but understanding the rate of change in CMD is critical for social and health policy planning. Effective follow-up of participants and collection of self-reported health status and clinic and hospital services as well as established biomarkers and verbal autopsies will lead to a comprehensive understanding of the complex biologic, behavioral, demographic, and socioeconomic factors causing increasing death and associated risk from cardiovascular and metabolic disorders. Our long term goal is to enrich the INDEPTH cohort studies systems in Ghana,.South Africa and Tanzania so they can be used to plan health and social services to identify high risk individuals who can benefit from simple interventions to reduce CMD morbidity and mortality. Our overall project objective is to establish a baseline of key traditional and novel CMD risk factors, assess trajectories of select risk factors, and test whether easily identified and modifiable risk factors predict future mortality in African populations 50 and over in diverse settings where infectious disease including HIV/AIDS is prominent. The specific aims of Project 2 are: 1. To compare baseline prevalence of risk factors and advanced CMD across 3 SSA communifies 2. To establish trajectories and patterns of change in traditional and novel CMD risk factors and established CVD 3. To develop models to assess the association between traditional and novel biologic risk factors, social and environmental risk factors, and CVD mortality in areas of differential HIV prevalence.

项目二：撒哈拉以南非洲地区老年人的心血管代谢疾病和危险因素心血管疾病（CVD）已成为全球流行病学，社会和经济转型的结果导致全球死亡的主要原因。这些转型在撒哈拉以南非洲（SSA）处于相对早期的阶段，所研究的国家处于不同的阶段，经历了截然不同的轨迹。该项目的目的是在南非、加纳和坦桑尼亚农村地区建立50岁及以上人群的队列，并在此过程中描述非洲人口结构转型环境中老年人心脏代谢紊乱的变化率、原因和后果。关于老年人慢性心血管疾病和糖尿病等慢性心血管代谢疾病（CMD）基线水平的可靠数据在农村SSA极为有限，但了解CMD的变化率对于社会和卫生政策规划至关重要。对参与者进行有效的随访，收集自我报告的健康状况、诊所和医院服务以及已建立的生物标志物和口头尸检，将有助于全面了解导致死亡增加的复杂生物学、行为学、人口统计学和社会经济因素以及心血管和代谢紊乱的相关风险。我们的长期目标是丰富加纳、南非和坦桑尼亚的INDEPTH队列研究系统，使其可用于规划卫生和社会服务，以确定可从简单干预中获益的高危人群，从而降低CMD发病率和死亡率。我们的总体项目目标是建立一个关键的传统和新的CMD风险因素的基线，评估选定的风险因素的轨迹，并测试是否容易识别和修改的风险因素预测未来的死亡率在非洲人口50岁及以上的不同设置，其中包括艾滋病毒/艾滋病的传染病是突出的。项目2的具体目标是： 1.比较3个SSA公报中风险因素和晚期CMD的基线患病率 2.建立传统和新型CMD风险因素以及已建立的CVD的变化轨迹和模式 3.开发模型，以评估传统和新的生物风险因素，社会和环境风险因素，以及在不同的艾滋病毒流行地区的心血管疾病死亡率之间的关联。