The XXII nd North American Testis Workshop

第二十二届北美睾丸研讨会

• 批准号: 8528943
• 负责人: WILLIAM Wallace WRIGHT
• 金额: $ 1.05万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528943
• 关键词: Address; American; Applications Grants; Benchmarking; Biochemical; Biology; Cellular biology; Clinical Research; Collaborations; Complement; Development; Disabled Persons; Educational workshop; Epigenetic Process; European; Event; Faculty; Feedback; Fertility; Fostering; Foundations; Funding; Future; Gene Expression; Gene Expression Regulation; Genes; Genetic; Genome; Germ Cells; Goals; Housing; Incidence; Infertility; Institutes; International; Male Contraceptions; Male Contraceptive Agents; Male Infertility; Malignant neoplasm of testis; Medical; Methods; Minnesota; Molecular; Molecular Biology; Molecular Genetics; Mutation; Organ; Process; Public Health; Regulation; Request for Applications; Research; Research Personnel; Rest; Scientist; Solutions; Somatic Cell; Spermatogenesis; Stem cells; Technology; Testis; Texas; Translational Research; Translations; Underrepresented Minority; United States; Universities; Washington; Woman; abstracting; career development; cost; deep sequencing; disability; genome-wide; graduate student; improved; lectures; male; meetings; member; men; posters; professor; programs; public health relevance; restoration; sertoli cell; sex determination; symposium

DESCRIPTION (provided by applicant): This R13 conference grant application requests funds to support the XXIInd North American Testis Workshop that will be held from April 13 to April 16, 2013 in San Antonio, Texas. Since 1972, the North American Testis Workshop has been the premiere international forum for bringing basic and clinician-scientists together to present and discuss the most recent findings on the regulation and function of the fertile and infertile testis The first goal of this meeting is to promote solutions for two major medical and public health problems: the high incidence of male infertility in the developed world and the lack of a safe and reversible male contraceptive. Another important goal of this meeting is to foster the development of future leaders in this field, especially if they currently are trainees, or if they re women or underrepresented minorities. The theme of the XXIInd North American Testis Workshop is, "The Foundations of Male Fertility." The program includes three major lectures: the keynote address, the benchmark lecture, and the European Molecular Biology Organization Young Investigator Lecture. There also will be 18 invited talks, which are grouped in five sessions. Session 1 is: Regulation and Restoration of Fertility in Men; Session 2 is: Genome Integrity; Session 3 is: Regulation of Gene Expression; Session 4 is: Somatic Cells; and Session 5 is: Stem Cells and Their Niche. In addition to the invited talks, each session will end with two short talks from abstracts that are submitted by young investigators (trainees and Assistant Professors who have been in rank for no more than 2 years.) The meeting also includes two poster sessions, and the posters will remain on display throughout the meeting. The keynote address begins the meeting and sets its tone. Dr. David Zarkower, Professor of Cell Biology and Genetics at the University of Minnesota, will present this lecture. Dr. Zarkower is one of the world's leading experts in the molecular and genetic control of sex determination. His research focuses on the function of DMRT1 and other DM-domain genes in sex determination of metazoans. As the key event in testis determination is the formation of Sertoli cells, his talk provides a foundation for Session 4, "Somatic Cells." Additionally, recent evidence indicates that mutations in the DMRT1 gene cause testicular cancer, a subject that is addressed in Session 2. The benchmark lecture highlights major advances in our understanding of testis regulation that are achieved through use of state-of-the-art technologies. Dr. Michael Griswold, Regents Professor, Washington State University, will present a genome-wide perspective on the regulation of spermatogenesis. Dr. Griswold pioneered the use of microarrays in the study of spermatogenesis and is now applying deep sequencing for a more detailed view of the changes in gene expression during male germ cell development. His talk will provide a foundation for Session 3. Dr. Antoine Peters of the Friedrich Miescher Institute will present The European Molecular Biology Organization Young Investigator Lecture. This lecture will address the epigenetic regulation of germ cell development, a topic that is also addressed in Session 3. A notable aspect of the program is the topic of Session 1, Regulation and Restoration of Fertility in Men. The Program Committee decided to begin with this topic in order to stimulate discussion throughout the meeting on the translation of basic studies in testis regulation and function to the treatment of infertile men and the development of male contraceptives. Presentations in the subsequent four sessions complement those in Session 1. In this application, we request funds to partially defray the cost of attendance of the 10 young investigators whose abstracts will be selected for short platform talks. The rest of the funds will defray part of the housing costs for the 20 distinguished scientists who have been invited to speak at this meeting.

描述（由申请人提供）：此R13会议补助金申请要求资金，以支持将于2013年4月13日至4月16日在德克萨斯州圣安东尼奥举行的XXIInd北美睾丸研讨会。自1972年以来，北美睾丸研讨会一直是首屈一指的国际论坛，将基础和临床科学家聚集在一起，介绍和讨论关于可育和不育睾丸的调节和功能的最新发现。本次会议的第一个目标是促进两个主要医疗和公共卫生问题的解决方案：发达国家男性不育症发病率高，缺乏安全和可逆的男性避孕药具。这次会议的另一个重要目标是促进这一领域未来领导人的发展，特别是如果他们目前是受训人员，或者如果他们是妇女或代表性不足的少数民族。 第二十二届北美睾丸研讨会的主题是“男性生育力的基础”。该计划包括三个主要讲座：主题演讲，基准讲座和欧洲分子生物学组织青年研究者讲座。此外，还将举办18场特邀讲座，分为五个部分。Session 1是：男性生育力的调节和恢复;第2节是：基因组完整性;第3节是：基因表达的调节;第4节是：体细胞;第5节是：干细胞及其生态位。除了邀请的演讲外，每个会议将以两个简短的演讲结束，这些演讲是由年轻的研究人员（实习生和助理教授）提交的。会议还包括两次海报会议，海报将在整个会议期间继续展出。 主旨发言是会议的开始，并确定了会议的基调。明尼苏达大学细胞生物学和遗传学教授大卫扎考尔博士将主持这次讲座。Zarkower博士是世界领先的性别决定的分子和遗传控制专家之一。他的研究重点是DMRT 1和其他DM结构域基因在后生动物性别决定中的功能。由于睾丸决定的关键事件是支持细胞的形成，他的演讲为第4节“体细胞”奠定了基础。“此外，最近的证据表明， 表明DMRT 1基因突变导致睾丸癌，这是第2节讨论的主题。 基准讲座强调了我们对睾丸调节的理解的重大进展，这些进展是通过使用最先进的技术实现的。华盛顿州立大学董事会教授Michael格里斯沃尔德博士将从全基因组角度阐述精子发生的调控。格里斯沃尔德博士开创了在精子发生研究中使用微阵列的先河，现在正在应用深度测序，以更详细地了解男性生殖细胞发育过程中基因表达的变化。他的演讲将为第三次会议提供基础。 Friedrich Miescher研究所的Antoine Peters博士将出席欧洲分子生物学组织青年研究者讲座。本次讲座将讨论生殖细胞发育的表观遗传调控，这也是在第3次会议上讨论的主题。 该方案的一个值得注意的方面是第一次会议的主题， 男人计划委员会决定开始这一主题，以激发整个会议的讨论，将睾丸调节和功能的基础研究转化为 治疗不育男性和开发男性避孕药。在随后的四场会议上的发言补充了第一场会议的发言。 在这份申请中，我们要求资金部分支付10名年轻研究人员的出席费用，他们的摘要将被选为简短的平台演讲。其余资金将用于支付应邀在本次会议上发言的20位杰出科学家的部分住房费用。