The XXII nd North American Testis Workshop

第二十二届北美睾丸研讨会

• 批准号: 8528943
• 负责人: WILLIAM Wallace WRIGHT
• 金额: $ 1.05万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528943
• 关键词: Address; American; Applications Grants; Benchmarking; Biochemical; Biology; Cellular biology; Clinical Research; Collaborations; Complement; Development; Disabled Persons; Educational workshop; Epigenetic Process; European; Event; Faculty; Feedback; Fertility; Fostering; Foundations; Funding; Future; Gene Expression; Gene Expression Regulation; Genes; Genetic; Genome; Germ Cells; Goals; Housing; Incidence; Infertility; Institutes; International; Male Contraceptions; Male Contraceptive Agents; Male Infertility; Malignant neoplasm of testis; Medical; Methods; Minnesota; Molecular; Molecular Biology; Molecular Genetics; Mutation; Organ; Process; Public Health; Regulation; Request for Applications; Research; Research Personnel; Rest; Scientist; Solutions; Somatic Cell; Spermatogenesis; Stem cells; Technology; Testis; Texas; Translational Research; Translations; Underrepresented Minority; United States; Universities; Washington; Woman; abstracting; career development; cost; deep sequencing; disability; genome-wide; graduate student; improved; lectures; male; meetings; member; men; posters; professor; programs; public health relevance; restoration; sertoli cell; sex determination; symposium

DESCRIPTION (provided by applicant): This R13 conference grant application requests funds to support the XXIInd North American Testis Workshop that will be held from April 13 to April 16, 2013 in San Antonio, Texas. Since 1972, the North American Testis Workshop has been the premiere international forum for bringing basic and clinician-scientists together to present and discuss the most recent findings on the regulation and function of the fertile and infertile testis The first goal of this meeting is to promote solutions for two major medical and public health problems: the high incidence of male infertility in the developed world and the lack of a safe and reversible male contraceptive. Another important goal of this meeting is to foster the development of future leaders in this field, especially if they currently are trainees, or if they re women or underrepresented minorities. The theme of the XXIInd North American Testis Workshop is, "The Foundations of Male Fertility." The program includes three major lectures: the keynote address, the benchmark lecture, and the European Molecular Biology Organization Young Investigator Lecture. There also will be 18 invited talks, which are grouped in five sessions. Session 1 is: Regulation and Restoration of Fertility in Men; Session 2 is: Genome Integrity; Session 3 is: Regulation of Gene Expression; Session 4 is: Somatic Cells; and Session 5 is: Stem Cells and Their Niche. In addition to the invited talks, each session will end with two short talks from abstracts that are submitted by young investigators (trainees and Assistant Professors who have been in rank for no more than 2 years.) The meeting also includes two poster sessions, and the posters will remain on display throughout the meeting. The keynote address begins the meeting and sets its tone. Dr. David Zarkower, Professor of Cell Biology and Genetics at the University of Minnesota, will present this lecture. Dr. Zarkower is one of the world's leading experts in the molecular and genetic control of sex determination. His research focuses on the function of DMRT1 and other DM-domain genes in sex determination of metazoans. As the key event in testis determination is the formation of Sertoli cells, his talk provides a foundation for Session 4, "Somatic Cells." Additionally, recent evidence indicates that mutations in the DMRT1 gene cause testicular cancer, a subject that is addressed in Session 2. The benchmark lecture highlights major advances in our understanding of testis regulation that are achieved through use of state-of-the-art technologies. Dr. Michael Griswold, Regents Professor, Washington State University, will present a genome-wide perspective on the regulation of spermatogenesis. Dr. Griswold pioneered the use of microarrays in the study of spermatogenesis and is now applying deep sequencing for a more detailed view of the changes in gene expression during male germ cell development. His talk will provide a foundation for Session 3. Dr. Antoine Peters of the Friedrich Miescher Institute will present The European Molecular Biology Organization Young Investigator Lecture. This lecture will address the epigenetic regulation of germ cell development, a topic that is also addressed in Session 3. A notable aspect of the program is the topic of Session 1, Regulation and Restoration of Fertility in Men. The Program Committee decided to begin with this topic in order to stimulate discussion throughout the meeting on the translation of basic studies in testis regulation and function to the treatment of infertile men and the development of male contraceptives. Presentations in the subsequent four sessions complement those in Session 1. In this application, we request funds to partially defray the cost of attendance of the 10 young investigators whose abstracts will be selected for short platform talks. The rest of the funds will defray part of the housing costs for the 20 distinguished scientists who have been invited to speak at this meeting.

描述(申请人提供)：此R13会议拨款申请申请资金，以支持将于2013年4月13日至4月16日在德克萨斯州圣安东尼奥举行的XXIInd北美睾丸研讨会。自1972年以来，北美睾丸研讨会一直是将基础和临床科学家聚集在一起介绍和讨论关于可育和不育睾丸的调节和功能的最新发现的主要国际论坛。这次会议的第一个目标是促进解决两个主要的医学和公共卫生问题：发达国家男性不育的高发病率和缺乏安全和可逆的男性避孕药。本次会议的另一个重要目标是促进这一领域未来领导人的发展，特别是如果他们目前是实习生，或者如果他们是妇女或代表性不足的少数群体。第21届北美睾丸研讨会的主题是“男性生育的基础”。该计划包括三个主要讲座：主旨演讲、基准讲座和欧洲分子生物学组织青年研究人员讲座。还将有18个受邀演讲，分五个环节进行。第1节是：男性生育能力的调节和恢复；第2节是：基因组完整性；第3节是：基因表达的调节；第4节是：体细胞；第5节是：干细胞及其生态位。除了受邀的演讲外，每节课还将有两个简短的演讲结束，这些摘要由年轻的研究人员(入职不超过两年的实习生和助理教授)提交。会议还包括两个海报会议，海报将在整个会议期间展示。主旨演讲拉开了会议的序幕，奠定了会议的基调。明尼苏达大学细胞生物学和遗传学教授David Zarkower博士将主持这次讲座。扎尔科尔博士是性别决定的分子和基因控制方面的世界领先专家之一。他的研究重点是DMRT1和其他DM结构域基因在后生动物性别决定中的功能。由于睾丸确定的关键事件是支持细胞的形成，他的演讲为第四次会议--“体细胞”奠定了基础。此外，最近的证据表明 指出DMRT1基因的突变会导致睾丸癌，这一主题将在第二节课中讨论。基准讲座强调了我们通过使用最先进的技术在理解睾丸调控方面取得的主要进展。华盛顿州立大学董事教授Michael Griswold博士将介绍精子发生调控的全基因组视角。格里斯沃尔德率先在精子发生研究中使用了微阵列，现在正在应用深度测序，以便更详细地观察男性生殖细胞发育过程中基因表达的变化。他的演讲将为第三堂课奠定基础。弗里德里希·米歇尔研究所的安托万·彼得斯博士将在欧洲分子生物学组织青年研究员讲座上发表演讲。这堂课将讨论生殖细胞发育的表观遗传调控，这一话题也在第三节课中讨论。该课程的一个值得注意的方面是第一节课的主题，即生育能力的调节和恢复 男人。方案委员会决定从这一专题开始，以便在整个会议期间促进关于将睾丸调节和功能的基础研究翻译成 不育男性的治疗和男性避孕药的开发。在这项申请中，我们要求提供资金，以支付10名年轻调查人员的部分出席费用，他们的摘要将被选作简短的平台演讲。其余的资金将支付20名受邀在这次会议上发言的杰出科学家的部分住宿费。