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Complexity Loss, Aging and the Dynamics of Frailty

复杂性丧失、衰老和脆弱的动态

基本信息

批准号：
8526311
负责人：
Madalena D Costa
金额：
$ 23.53万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526311
关键词：
Address Affect Aging American Award Biological Markers Biology of Aging Biomedical Engineering Blood Pressure Cognitive Complex Data Databases Development Elderly Equilibrium Erythrocytes Exhibits Faculty Fostering Functional disorder Funding Generic Drugs Goals Health Health Care Costs Health Status Heart Rate Human Impairment Incidence Instruction Measurement Measures Methods Morbidity - disease rate Musculoskeletal Equilibrium Nursing Homes Organ Pathologic Pathway interactions Peripheral Phase Physics Physiological Physiology Population Program Research Project Grants Property Public Health Research Research Personnel Research Training Rest Risk Series Stratification Syndrome System Testing Therapeutic Intervention Time Work base career follow-up frailty heart rhythm member mortality neuromuscular new technology novel strategies pressure programs response therapy design

项目摘要

This application constitutes the request to transition to the ROO phase of a K99 Pathway to Indepentdence Awarid aimed at fostering and expanding ail the inter-related components of a academic career in basic and applied aspects of human aging. Dr. IVladalena Costa's long-term research goals are: (i) to understand basic mechanisms of nonlinear biologic and physiologic control in health and their degradation with aging and frailty, (ii) to develop a new class of dynamical biomarkers that quantify integrative function and give information about pathophysiology not obtainable with traditional probes, and (iii) to determine the value of this new class of dynamical biomarlcers for risk stratification and the assessment of therapeutic interventions designed to reverse or retard pathologic aging. Her work is at the interfaces of statistical physics, bioengineering, physiology, and the biology of aging. Two emerging themes of this interdisciplinary work are that healthy systems, which are marked by robustness and adaptability, exhibit the most complex multiscale dynamics, and that aging and the frailty syndrome in particular, are marked by a loss of complex multiscale variability and adaptive capacity. Dr. Costa's K99 award has allowed her to become an independent investigator working at the interface between complex systems and the biologic of aging. Her specific research aims for the ROO phase as presented in the original proposal remain unchanged. Propelled by the foundational K99 training and research work. Dr. Costa is also pursuing a number of inter-related sub-projects as part of her coherent program as a full time faculty member. The specific aims are: 1) to elucidate nonlinear mechanisms of integrative physiologic control by developing dynamical biomarkers that quantify multiscale fluctuations; 2) to test the hypothesis that the dynamical complexity of physiologic regulatory mechanisms degrades with aging in representative systems ranging from the cellular to organ, and 3) to test the hypothesis that loss of complexity in physiologic systems over time can be predictive of overall health status degradation and subsequent development of frailty.

该应用程序构成了向K99独立路径的ROO阶段过渡的请求