Metabolic Syndrome as Women Undergo Menopausal Transition: A Multi-Ethnic Study

女性绝经过渡期的代谢综合征：一项多种族研究

• 批准号: 8899959
• 负责人: Jennifer S Lee
• 金额: $ 2.81万
• 依托单位: PALO ALTO VETERANS INSTIT FOR RESEARCH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8899959
• 关键词: Metabolic; Syndrome; Women; Undergo; Menopausal

DESCRIPTION (provided by applicant): Young women have much lower rates of cardiovascular disease (CVD, including stroke) than men. However, as midlife women transition to post-menopause, they lose this 'cardiovascular protection,' and CVD is most common in post-menopause than any other stage of a woman's lifespan. Metabolic Syndrome (MetS) is a clustering of 5 metabolic abnormalities and is a major predictor of CVD and type 2 diabetes. MetS is clinically diagnosed as having any, and at least, 3 of the 5 components. MetS occurrence increases during the menopausal transition (MT). Reasons for this are unclear; however this may be due to androgen excess, relative to estrogen, during the MT. The proposal's goal is to establish basic aspects of how the constellations of the MetS components evolve during the course of the MT, a key 5- to 10-year biological stage in a woman's lifespan. In turn, this is intended to identify customized ways of preventing MetS early and related CVD and diabetes, with effective intervention strategies during the MT. The proposal incorporates a shift in our thinking of menopause and sex hormones in midlife women, namely, that the increase in MetS occurrence may be due more to androgen gain (and less to estrogen loss), in the MT. Our starting hypothesis is that mapping the constellations of MetS components, and the number of MetS components satisfied, in the midlife will provide a window into bridging the MT, its changing sex hormones, and loss of CV protection in women. If correct, this would shift our clinical focus to individualize hormone strategies against characteristic MetS constellations and related CVD and diabetes in midlife and early post-menopausal women. Aim 1. To characterize the constellations of MetS components satisfied over time in women, of 5 race/ethnicities, who develop MetS as they undergo the MT. Aim 2. To determine the hormonal and inflammatory factors that predict the course of MetS constellations in midlife women as they undergo the MT. We propose an efficient study that analyzes unique, existing longitudinal data from the largest U.S. study of the MT, the Study of Women Across the Nation (SWAN), a multi-ethnic cohort of 3302 women. Our long-term objective is to prevent the dramatic increase in CVD in older women by implementing, in midlife, individualized preventative strategies. Both our aims bear directly on this wider objective. These would impact 60+ million midlife and older U.S. women.

描述（由申请人提供）：年轻女性患心血管疾病（CVD，包括中风）的几率远低于男性。然而，随着中年女性过渡到绝经后，她们失去了这种“心血管保护”，心血管疾病在绝经后比女性生命中的任何其他阶段都更常见。代谢综合征（MetS）是5种代谢异常的聚类，是心血管疾病和2型糖尿病的主要预测因子。临床诊断为具有5种成分中的任何一种或至少3种。在绝经过渡期（MT）， MetS的发生率增加。原因尚不清楚；然而，这可能是由于MT期间雄激素过量，相对于雌激素。该提案的目标是建立在MT过程中MetS组成部分的星座演变的基本方面，MT是女性生命中5到10年的关键生物阶段。反过来，这旨在通过MT期间有效的干预策略，确定早期预防MetS以及相关CVD和糖尿病的定制方法。该提案结合了我们对中年女性更年期和性激素的看法的转变，即在MT中，MetS发生率的增加可能更多地归因于雄激素的增加（而不是雌激素的损失）。我们的初始假设是，和满足的met成分的数量，在中年将提供一个窗口来连接MT，其性激素的变化，以及女性心血管保护的丧失。如果正确的话，这将把我们的临床重点转移到针对中年和早期绝经后妇女的特征性MetS星座和相关CVD和糖尿病的个体化激素策略上。目的1。在5个种族/民族的女性中，在接受MT时发展为MetS，随着时间的推移，其met成分的星座得到满足。目的2。为了确定激素和炎症因素在中年女性接受MT时预测met星座的进程。我们提出了一项有效的研究，分析了美国最大的MT研究中独特的、现有的纵向数据，即全国妇女研究（SWAN），一个多种族的3302名妇女队列。我们的长期目标是通过在中年实施个体化预防策略来预防老年妇女心血管疾病的急剧增加。我们的两个目标都直接关系到这个更广泛的目标。这将影响6000多万美国中年和老年妇女。