Assessment of Prevalence and Trends of Metabolic Syndrome among Bangladeshi Rural Women : From basic epidemiology to genetic screening

孟加拉国农村妇女代谢综合征的患病率和趋势评估：从基础流行病学到基因筛查

• 批准号: 22406025
• 负责人: HIROE Michiaki
• 金额: $ 12.23万
• 依托单位: Research Institute, International Medical Center of Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406025/
• 关键词: メタボリック症候群; 横断研究; バングラデシュ国; 農村部女性; 生物マーカー; 有病率; 年齢層; 遺伝学; バングラデシュ; 農村女性; 疫学調査; 遺伝学的研究

Metabolic Syndrome (MS) has been replaced by 'global cardiometabolic risk, which is a complex disorder and an emerging clinical challenge. MS, defined as a constellation of cardiovascular disease (CVD) risk factors, is one of the growing public health burdens in the Asia-Pacific region, even though people in this region are no more overweight than Europeans and Americans. Comparative studies indicate that metabolic responses to obesity may be greater in South and East Asians than their western counterparts at given Body Mass Indexes (BMIs). But MS screening has only been done in a few countries of South East Asia, excluding Bangladesh. The present study was designed to conduct a comprehensive screening of metabolic syndrome in Bangladeshi rural women, including prevalence estimation and biomarker assessment. The clinical relevance of MS is that it identifies people who are at increased long-term risk of cardiovascular disease and type 2 Diabetes (T2DM), thus providing an opportunity for preventive lifestyle interventions.

代谢综合征（MS）已被“全球心脏代谢风险”所取代，这是一种复杂的疾病和新兴的临床挑战。MS被定义为一系列心血管疾病（CVD）风险因素，是亚太地区日益增长的公共卫生负担之一，尽管该地区的人们并不比欧洲人和美国人超重。比较研究表明，在特定的身体质量指数（BMI）下，南亚和东亚人对肥胖的代谢反应可能比西方人更大。但是MS筛查只在东南亚的少数国家进行，不包括孟加拉国。本研究旨在对孟加拉国农村妇女进行代谢综合征的全面筛查，包括患病率估计和生物标志物评估。MS的临床相关性在于，它可以识别心血管疾病和2型糖尿病（T2DM）长期风险增加的人群，从而为预防性生活方式干预提供了机会。

项目成果

Effect of Endotnelth-A/-B dual antagonism on the angiogenic growth ractor alteration and regional cerebral blood flow in the frontal cortex of SHR-SP

Endotnelth-A/-B双重拮抗作用对SHR-SP额叶皮层血管生成因子改变和局部脑血流的影响

• 发表时间: 2012
• 作者: Jesmin;Hiroe;et al.
• 通讯作者: et al.

Coronary Artery CT Low-Density Plague Area and Its Ratio to the Whole Area of a Non-Calcified Plaoue at the Culprit Lesion in Patients with Unstable and Stable Coronary Artery Disease.

不稳定和稳定冠状动脉疾病患者冠状动脉CT低密度斑块面积及其与罪魁祸首处非钙化斑块总面积的比例。

• 发表时间: 2012
• 期刊: International Heart Journal
• 影响因子: 1.5
• 作者: Jesmin S;et al.
• 通讯作者: et al.

Measurement of cerebral blood flow with 99mTc-ECD SPECT and its potential clinical implications-analyzing the relationships between CBF and lifestyle disease

99mTc-ECD SPECT脑血流测量及其潜在临床意义——分析CBF与生活方式病的关系

• 发表时间: 2012
• 期刊: Kaku Igaku
• 作者: Nemoto H;Nakai Y;Hatakeyama R;Shikano N;Jesmin S;Yamaguchi N
• 通讯作者: Yamaguchi N

Angiogenic factors and their soluble receptors for predicting organ dysfunction in disseminated intravascular coagulation associated with sepsis

血管生成因子及其可溶性受体用于预测脓毒症相关弥散性血管内凝血器官功能障碍

• 发表时间: 2012
• 期刊: Journal of Critical Care
• 影响因子: 3.7
• 作者: Jesmin S;et al
• 通讯作者: et al

Socioeconomic Status and Metabolic Syndrome among Rural Women of Bangladesh

孟加拉国农村妇女的社会经济地位和代谢综合征

• 发表时间: 2011
• 作者: Islam AMS;Jesmin S;Islam MR;Mia MS;Sultana SN;Zaedi S;Kimura S
• 通讯作者: Kimura S