IGF::OT::IGF LASER-DRIVEN PROTON AND CARBON THERAPY

IGF::OT::IGF 激光驱动质子和碳疗法

• 批准号: 8742678
• 负责人: FINN O'SHEA
• 金额: $ 29.99万
• 依托单位: RADIABEAM TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2014-06-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742678
• 关键词: Acceleration; Address; Cancer Patient; Carbon; Carbon ion; Clinics and Hospitals; Ions; Lasers; Malignant Neoplasms; Optics; Patients; Performance; Phase; Protons; Quality of life; Radiation Oncology; Radiation therapy; Survival Rate; System; Technology; Texas; Treatment Efficacy; Universities; austin; clinical application; conditioning; cost; design; improved; innovation; novel; proton beam; proton therapy; technology development

While the superior therapeutic efficacy of hadron therapy has been clearly demonstrated, its availability to cancer patients is limited by the cost and size of current systems. The proposed project seeks to address this problem by utilizing innovative laser-driven ion acceleration technology for the development of a compact, inexpensive proton therapy system that can ultimately be adapted for the acceleration of carbon ions. High-intensity, 200-300 MeV laser-driven proton beams will be demonstrated with the Texas Petawatt Laser through the implementation of several novel acceleration mechanisms with ultrathin CH2 targets. RadiaBeam Technologies, the University of Texas at Austin , and the UCLA Department of Radiation Oncology will collaborate on the conceptual design of a treatment system for delivering proton therapy, and eventually carbon therapy, with performance sufficient for clinical application at a fraction of the cost and fitting in a single room. This major reduction in size and cost of hadron therapy will make the proposed system a much more realistic option for hospitals and clinics worldwide, thus expanding the pool of patients to which this treatment is available and potentially improving cancer survival rates as well as the quality of life for radiotherapy patients.

虽然强子疗法的上级治疗效果已被清楚地证明， 癌症患者受到当前系统的成本和尺寸的限制。拟议项目旨在解决 这一问题，通过利用创新的激光驱动离子加速技术的发展， 紧凑，廉价的质子治疗系统，最终可以适用于加速碳 离子。高强度，200-300兆电子伏激光驱动的质子束将被证明与得克萨斯州拍瓦 激光通过实施几种新的加速机制与CH_2CH_2目标。 RadiaBeam Technologies、德克萨斯大学奥斯汀分校和加州大学洛杉矶分校辐射系 肿瘤科将合作进行质子治疗系统的概念设计， 最终碳疗法，其性能足以在成本的一小部分下用于临床应用， 适合在一个房间里。强子疗法的尺寸和成本的大幅降低将使拟议的 系统对于全世界的医院和诊所来说是一个更现实的选择，从而扩大了病人的数量。 这种治疗方法是可行的，并可能提高癌症生存率以及治疗质量。 放疗患者的生活。