Lung and HIV Analytical Data Coordinating Center (LHAD-CC)

描述(由申请人提供)：本申请的目的是建立肺和艾滋病毒分析数据协调中心(LHAD-CC)，该中心将与配套的FOA RFA-HL-13-026资助的研究网站合作。我们的网站将共同组成一个新的协作网络(HLDN)。LHAD-CC将在提供科学领导和流行病学、统计学、遗传学、临床和基础肺病研究专业知识方面发挥领导作用，同时为HLDN的成功提供必要的支持，包括研究网络的协调(例如促进合作、安排会议、样本跟踪)、研究网络的数据管理(例如建立稳定和高效的基于网络的数据管理系统、质量控制和数据协调)以及对合作项目的分析支持。LHAD-CC的具体目标是：(1)为HLDN开发新的方法提供科学领导；(2)通过协作和科学伙伴关系，优化HLDN网络在了解艾滋病毒有效治疗时代肺部疾病发病机制方面的贡献；(3)协调研究倡议和科学陈述；促进网络调查人员、工作组和委员会之间的沟通；协调研究方案的制定；以及传播关键科学发现(卷宗、档案和研究网站)；(4)调整、维护和完善我们目前稳定和高效的基于Web的数据管理系统，以适应HLDN的需要。我们将定制我们目前的系统：跟踪中央存储库中生物标本的存储和转移，生成年度公共数据集，并进行方法培训，以促进研究数据的适当使用，用于本地研究；(5)与临床站点合作实施质量保证计划，整合数据管理、研究协调、统计方法和科学学科方面的专业知识。该计划将监测整个研究的质量，并促进数据收集的遵守和培训。

DESCRIPTION (provided by applicant): The purpose of this application is to establish the Lung and HIV Analytical Data Coordinating Center (LHAD- CC) that will collaborate with the research sites funded under the companion FOA RFA-HL-13-026. Together, our sites will form a new collaborative network (HLDN). LHAD-CC will provide leadership in contributing scientific leadership and epidemiological, statistical, genetic, clinical, and basic pulmonary research expertise while providing essential support for the success of the HLDN including coordination of the research network (e.g. facilitating collaborations, arranging meetings, specimen tracking), data management for the research network (e.g. establishment of a stable and efficient web-based data management system, quality control, and data harmonization), and analytical support for collaborative projects. The specific aims of LHAD-CC are: (1) To provide scientific leadership for the HLDN in developing novel methodology; (2) To optimize the contributions of the network for HLDN in the understanding of the pathogenesis of lung disease in an era of effective treatment of HIV through collaboration and scientific partnership; (3) To coordinate research initiatives and scientific presentations; to facilitate communication amongst network investigators, Working Groups and committees; to orchestrate study protocol development; and to disseminate key scientific findings (Dossier, Archives, & Study Website); (4) To adapt, maintain, and refine our current stable and efficient web- based data management system to the needs of HLDN. We will tailor our current systems for: tracking the storage and transfer of biological specimens at a central repository, producing annual public data sets, and conducting training in methods in order to facilitate the appropriate use of study data for local research; (5 To implement a quality assurance program in partnership with the clinical sites that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines. This program will monitor study-wide quality and promote adherence and training for data collection.