Lung and HIV Analytical Data Coordinating Center (LHAD-CC)

描述（由申请人提供）：本申请的目的是建立肺部和HIV分析数据协调中心（LHAD- CC），该中心将与FOA RFA-HL-13-026配套文件资助的研究中心合作。我们的网站将共同形成一个新的协作网络（HLDN）。LHAD-CC将在贡献科学领导力和流行病学、统计学、遗传学、临床和基础肺部研究专业知识方面发挥领导作用，同时为HLDN的成功提供必要的支持，包括协调研究网络（例如促进合作、安排会议、标本追踪），研究网络的数据管理（例如建立一个稳定和有效的网上数据管理系统、质量控制和数据协调），以及为合作项目提供分析支持。LHAD-CC的具体目标是：（1）在开发新方法方面为HLDN提供科学领导;（2）通过合作和科学伙伴关系，在有效治疗艾滋病毒的时代，优化HLDN网络在理解肺部疾病发病机制方面的贡献;（3）协调研究举措和科学演示;促进网络研究者、工作组和委员会之间的沟通;协调研究方案的制定;以及传播关键的科学发现（档案，档案和研究网站）;（4）根据HLDN的需要调整、维护和完善我们目前稳定高效的基于网络的数据管理系统。我们将调整现有的系统，以便：在中央储存库跟踪生物标本的储存和转移，制作年度公共数据集，并进行方法培训，以促进适当使用研究数据进行当地研究;（5）与临床研究中心合作实施质量保证计划，该计划整合了数据管理、研究协调、统计方法学、和科学学科。该计划将监测整个研究的质量，并促进数据收集的依从性和培训。

DESCRIPTION (provided by applicant): The purpose of this application is to establish the Lung and HIV Analytical Data Coordinating Center (LHAD- CC) that will collaborate with the research sites funded under the companion FOA RFA-HL-13-026. Together, our sites will form a new collaborative network (HLDN). LHAD-CC will provide leadership in contributing scientific leadership and epidemiological, statistical, genetic, clinical, and basic pulmonary research expertise while providing essential support for the success of the HLDN including coordination of the research network (e.g. facilitating collaborations, arranging meetings, specimen tracking), data management for the research network (e.g. establishment of a stable and efficient web-based data management system, quality control, and data harmonization), and analytical support for collaborative projects. The specific aims of LHAD-CC are: (1) To provide scientific leadership for the HLDN in developing novel methodology; (2) To optimize the contributions of the network for HLDN in the understanding of the pathogenesis of lung disease in an era of effective treatment of HIV through collaboration and scientific partnership; (3) To coordinate research initiatives and scientific presentations; to facilitate communication amongst network investigators, Working Groups and committees; to orchestrate study protocol development; and to disseminate key scientific findings (Dossier, Archives, & Study Website); (4) To adapt, maintain, and refine our current stable and efficient web- based data management system to the needs of HLDN. We will tailor our current systems for: tracking the storage and transfer of biological specimens at a central repository, producing annual public data sets, and conducting training in methods in order to facilitate the appropriate use of study data for local research; (5 To implement a quality assurance program in partnership with the clinical sites that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines. This program will monitor study-wide quality and promote adherence and training for data collection.