Biomedical Researcher Development Program in TMJD and Orofacial Pain

描述(申请人提供)：颞下颌关节紊乱病(TMJD)和口腔面部疼痛(OFP)是复杂和多因素的疼痛障碍，涉及遗传、社会、文化、生物行为和环境因素。为了有效地管理这些情况，需要由TMJD和OFP基础和临床研究人员组成的多学科和跨学科团队来充分解决这些情况的多因素性质。本文件代表了北卡罗来纳大学教堂山分校(UNC-CH)牙科医学院神经感觉障碍(CNSD)中心对NIDCR PAR-11-289：机构职业发展奖，以提高在颞颌关节疾病和口腔面部疼痛(K12)方面的研究能力的机构回应。这项拟议的生物医学研究员发展奖学金(BRDS)计划的目的是培养一批成功和独立的基础、临床和翻译研究学者，他们可以领导多学科研究团队将新方法应用于TMJD和OFP研究，从而提高对这些疾病的理解，并导致更有效的诊断和治疗方法。我们的计划涵盖了全方位的基础、转换和临床研究，包括急性和慢性疼痛的机制、治疗干预、临床试验、流行病学、社会和行为临床研究，与TMJD、OFP和相关的并存疼痛障碍相关。将强调对导致TMJD和OFP的生物、心理、社会和分子遗传机制的强烈关注。BRD学者将有机会开展受监督的生物医学、流行病学、卫生服务/卫生政策或临床研究，主要目标是发展或增强多学科合作研究技能和知识，为与NIDCR的使命相关的独立研究事业做准备。该职业发展奖旨在通过实现以下目标来提高TMJD和OFP研究领域的学者的研究能力：1)吸引和吸引来自不同生物医学背景的初级或新的基础和临床研究人员进入TMJD和OFP研究领域；2)指导和培养这些研究学者，并使他们具备在TMJD和OFP领域从事独立研究事业所需的知识和技能；3)将研究学者整合到一个多学科和跨学科的研究环境中，以促进协作科学进步的发展，并增强个人的技能和专长；4)协助BRD学者开发K08、K23或R系列奖项，或通过其他研究培训支持和职业发展机制；5)培训这些研究学者，使其成为未来多学科和跨学科协作研究团队的领导者；以及6)在完成BRD后继续支持和指导学者。我们的目标是培养一支新的多学科和高度互动的科学家干部队伍，他们可以作为下一代TMJD和OFP研究的领导者。 公共卫生相关性：这项拟议的生物医学研究员发展奖学金(BRDS)计划的目的是培养成功和独立的基础、临床和翻译研究学者，他们可以领导多学科研究团队将新方法应用于TMJD和OFP研究，从而提高对这些疾病的理解，并导致更有效的诊断和治疗方法。

DESCRIPTION (provided by applicant): Temporomandibular Joint Disorders (TMJD) and Orofacial Pain (OFP) are complex and multi-factorial pain disorders involving genetic, social, cultural, biobehavioral, and environmental factors. To effectively manage these conditions, multi-and inter-disciplinary teams of TMJD and OFP basic and clinical researchers are needed to adequately address the multi-factorial nature of these conditions. This document represents an institutional response from the University of North Carolina at Chapel Hill (UNC-CH) School of Dentistry's (SOD) Center for Neurosensory Disorders (CNSD) to NIDCR PAR-11-289: Institutional Career Development Award for Enhancing Research Capacity in Temporomandibular Joint Disorders and Orofacial Pain (K12). The purpose of this proposed Biomedical Researcher Development Scholarship (BRDS) program is to develop a cohort of successful and independent basic, clinical and translational research scholars who can lead multi- disciplinary research teams to apply novel approaches to TMJD and OFP research that will improve the understanding of these disorders and lead to more effective methods of diagnosis and treatment. Our program embraces the full spectrum of basic, translational and clinical research including mechanisms of acute and chronic pain, therapeutic intervention, clinical trials, epidemiology, social, and behavioral clinical research related to TMJD, OFP and related comorbid pain disorders. A strong focus on the biopsychosocial and molecular genetic mechanisms that contribute to TMJD and OFP will be emphasized. BRD scholars will have the opportunity to carry out supervised biomedical, epidemiological, health services/health policy, or clinical research with the primary objective of developing or enhancing multi-disciplinary collaborative research skills and knowledge in preparation for an independent research career relevant to the mission of the NIDCR. This career development award proposes to enhance the research capacity of scholars in the field of TMJD and OFP research by achieving the following objectives: 1) To attract and engage junior or new basic and clinical investigators trained in sciences relevant to TMJD and OFP who are from diverse biomedical backgrounds into the field of TMJD and OFP research; 2) To mentor and nurture these research scholars and equip them with the necessary knowledge and skills to pursue independent research careers in TMJD and OFP; 3) To integrate the research scholars into a multi- and inter-disciplinary research environment that will foster the development of collaborative scientific advancement as well as enhance individual skills and expertise; 4) To assist BRD scholars with the development of K08, K23 or R series awards, or with other mechanisms of research training support and career development; 5) To groom these research scholars to become future leaders of multi- and inter-disciplinary collaborative research teams; and 6) To continue to support and mentor scholars following completion of their BRDS. Our goal is to create a new cadre of multi-disciplinary and highly interactive scientists who can serve as the next generation of TMJD and OFP research leaders. PUBLIC HEALTH RELEVANCE: The purpose of this proposed Biomedical Researcher Development Scholarship (BRDS) program is to develop successful and independent basic, clinical and translational research scholars who can lead multi-disciplinary research teams to apply novel approaches to TMJD and OFP research that will improve the understanding of these disorders and lead to more effective methods of diagnosis and treatment.