An ontology for pain and related disability, mental health and quality of life.

疼痛和相关残疾、心理健康和生活质量的本体论。

• 批准号: 8255448
• 负责人: Werner M Ceusters
• 金额: $ 38.95万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8255448
• 关键词: Age; Anatomy; Anxiety; British; Buffaloes; Clinic; Clinical; Clinical Course of Disease; Collaborations; Consensus; Data; Data Set; Databases; Dentistry; Development; Diagnostics Research; Dictionary; Disease; Exhibits; Face; Facial Pain; Faculty; Functional disorder; Funding; Gender; Generic Drugs; German population; Germany; Goals; Headache; Health Professional; Impairment; International; Israel; Laboratory Research; Language; Measures; Medical; Mental Depression; Mental Health; Methods; Minnesota; Modeling; Musculoskeletal Diseases; Natural History; Nature; Ontology; Oral; Oral health; Orofacial Pain; Pain; Pain Clinics; Pain Disorder; Pain Measurement; Pain management; Pain-Free; Patients; Persistent pain; Phenotype; Prosthodontic specialty; Psychological Models; Psychosocial Factor; Publishing; Quality of life; Recruitment Activity; Reporting; Resort; Science; Semantics; Sorting - Cell Movement; Subgroup; Sweden; Symptoms; Technology; Temporomandibular Joint; Temporomandibular Joint Disorders; Temporomandibular joint disorder pain; Toothache; Translating; United States National Institutes of Health; Universities; Validation; Washington; Work; base; biomedical ontology; biopsychosocial; design; disability; health related quality of life; insight; instrument; interest; public health relevance; special interest group; theories; trait

DESCRIPTION (provided by applicant): The goal of this project is to obtain better insight into the complexity of pain disorders, specifically concerning the assessment of different pain types as well as pain-related disablement and its association with mental health and quality of life. This will be achieved by developing an ontology which will then be used to integrate five existing datasets that broadly encompass the major types of pain (orofacial pains, temporomandibular disorder pain, headache) recognized to occur in the oral and associated regions and incorporating a broad array of measures consistent with a biopsychosocial perspective regarding pain. Patients complaining of a single regional persistent pain typically manifest symptoms suggestive of more than one pain disorder. Presently, and although still uncertain, the pain field regards different types of pain as emerging from different mechanisms. Consequently, patients suffering from a given type of persistent pain receive treatments based on how that pain has been classified, perhaps inappropriately. The datasets cover the same domain, but are distinct in various respects: (1) some variables are identical across datasets, others involving, for instance, somatization, depression and anxiety, are different because measured with distinct instruments; (2) the data exhibit different levels of granularity; (3) because of their distinct origins (US, UK, Sweden, Israel, and Germany), the datasets incorporate cultural influences related to pain report that have an impact on the comparability of the data sets, despite the use of common instruments. The ontology will make it possible to describe the datasets in a uniform and formal way, and be general enough to include other datasets in the same domain once they become available. The importance of this endeavor lays in its contribution to solving an important problem, namely that the phenotype of many pain conditions is insufficiently defined in terms of the scope, the natural history and/or clinical course of the disease subgroup of interest, and, most importantly, with respect to disease traits for which laboratory research has provided important pathogenetic insight. The main clinical question that we will be able to answer by merging these datasets is how patho-anatomy and pathophysiology - in this case in the context of TMD and orofacial pains - have an impact on pain-related disablement and quality of life. Because the ontology will provide a formal representation of widely used assessment instruments in the domain of mental health, its applicability will exceed by far the more narrow domain that is covered in the proposed project for practical reasons. The ontology will be built following the widely accepted and in Nature published principles adhered to in the Open Biomedical Ontology Foundry (OBO-Foundry, using Basic Formal Ontology (BFO), and Referent Tracking (RT) as generic semantic technologies. By working in collaboration with The International RDC/TMD Consortium Network, and the Orofacial Pain Special Interest Group of the International Association for the Study of Pain, this ontology is likely to become a standard in the domain. PUBLIC HEALTH RELEVANCE: There is general consensus that combined biomedical and biopsychosocial methods best support the assessment and management of pain and dysfunction caused by musculoskeletal disorders and the impact thereof on mental health and quality of life. The ontology to be developed in the proposed effort embodies the conceptual theories underlying relevant biomedical models (anatomy and pathophysiology related to temporomandibular joints), psychological models and biopsychosocial models. It thus supports an integrated and multidimensional approach concerning physical and psychosocial factors involved in pain and dysfunction, and will help in the conceptualization and management of pain-related disorders for various health care professionals.

描述（由申请人提供）：该项目的目标是更好地了解疼痛疾病的复杂性，特别是关于不同疼痛类型的评估以及疼痛相关的残疾及其与心理健康和生活质量的关系。这将通过开发一个本体来实现，然后将其用于整合五个现有的数据集，这些数据集广泛涵盖了公认的发生在口腔和相关区域的主要类型的疼痛（口面疼痛，颞下颌关节紊乱疼痛，头痛），并结合了广泛的一系列与生物心理社会角度一致的关于疼痛的措施。主诉单一区域持续性疼痛的患者通常表现出提示不止一种疼痛障碍的症状。目前，尽管还不确定，疼痛领域认为不同类型的疼痛是由不同的机制引起的。因此，患有给定类型的持续性疼痛的患者接受基于疼痛如何分类的治疗，这可能是不恰当的。这些数据集涵盖了相同的领域，但在各个方面是不同的：（1）一些变量在数据集之间是相同的，其他变量包括，例如，躯体化，抑郁和焦虑，是不同的，因为用不同的工具测量;（2）数据表现出不同的粒度水平;（3）由于其独特的起源（美国、英国、瑞典、以色列和德国），数据集纳入了与疼痛报告相关的文化影响，这些文化影响对数据集的可比性有影响，尽管使用的是通用工具。本体将使得以统一和正式的方式描述数据集成为可能，并且一旦它们变得可用，就足够通用以包括同一领域中的其他数据集。这种奋进的重要性在于其对解决一个重要问题的贡献，即许多疼痛病症的表型在感兴趣的疾病亚组的范围、自然史和/或临床过程方面定义不足，并且最重要的是，关于实验室研究提供了重要的发病机理见解的疾病特征。通过合并这些数据集，我们将能够回答的主要临床问题是病理解剖学和病理生理学-在这种情况下，在TMD和口面疼痛的背景下-如何对疼痛相关的残疾和生活质量产生影响。由于本体论将提供一个正式的表示，广泛使用的评估工具在精神健康领域，其适用性将远远超过更狭窄的领域，在拟议的项目中所涵盖的实际原因。该本体将遵循开放生物医学本体铸造（OBO-铸造）中广泛接受的和在自然界发表的原则，使用基本形式本体（BFO）和引用跟踪（RT）作为通用语义技术。通过与国际RDC/TMD联盟网络和国际疼痛研究协会的口面疼痛特别兴趣小组合作，该本体很可能成为该领域的标准。 公共卫生相关性：人们普遍认为，生物医学和生物心理社会相结合的方法最能支持评估和管理肌肉骨骼疾病引起的疼痛和功能障碍及其对心理健康和生活质量的影响。在拟议的努力中开发的本体体现了相关的生物医学模型（解剖学和病理生理学相关的颞下颌关节），心理模型和生物心理社会模型的概念理论。因此，它支持一个综合的和多方面的方法，涉及疼痛和功能障碍的身体和心理因素，并将有助于各种医疗保健专业人员的疼痛相关疾病的概念化和管理。