Research Training in Gene-Environment Interaction in China

中国基因与环境相互作用研究培训

• 批准号: 8335700
• 负责人: Dongfeng Gu
• 金额: $ 22.98万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-16 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335700
• 关键词: Academy; Award; Biometry; Cardiovascular Diseases; Cardiovascular system; China; Chinese People; Chronic; Chronic Disease; Clinical; Clinical Research; Collaborations; Communicable Diseases; Congresses; Disease; Doctor' s Degree; Environmental Exposure; Epidemiologic Methods; Epidemiologic Studies; Epidemiologist; Epidemiology; Faculty; Genetic; Genetic Predisposition to Disease; Genetic Variation; Genomics; Heart; Hospitals; Human; Institutes; Interdisciplinary Study; International; Joints; Knowledge; Laboratory Research; Leadership; Longevity; Medical; Mentorship; Molecular Genetics; NIH Program Announcements; Play; Population Research; Public Health Schools; Recruitment Activity; Research; Research Methodology; Research Personnel; Research Training; Role; Science; Trainers Training; Training; Training Programs; Tropical Medicine; Universities; Work; design; experience; gene environment interaction; genetic epidemiology; graduate student; medical schools; multidisciplinary; programs; response; skills; statistics

DESCRIPTION (provided by applicant): This is a joint application of the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, the Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and the National Center for Cardiovascular Diseases of China to provide research training in gene-environment interaction in chronic diseases across the lifespan in China in response to Program Announcement: Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43). Most chronic, non-communicable diseases and disorders are likely determined by genetic predisposition, environmental exposure and their interactions. This multidisciplinary training program is built on the long- standing collaboration in chronic disease research between the US and Chinese participating institutes and aims to strengthen capacity for gene-environment interaction research in chronic diseases in China. The specific aims are: (1) to establish a unique, interdisciplinary program for graduate students pursuing doctoral degrees at the Peking Union Medical College (PUMC), with a strong emphasis on multidisciplinary research training designed to study genetic variation, environmental exposure, and their interactions in chronic diseases in China. After the first year of course work at PUMC in China, the trainees will take advanced courses in genetics, statistics, epidemiology and clinical research methods, as well as gain experience in population or laboratory research, during their second year at Tulane University in the US. The trainees will conduct their dissertation research in China under co-mentorship from faculty at PUMC and Tulane. They will receive their doctoral degrees from PUMC; (2) To provide multidisciplinary postdoctoral research training in gene- environment interaction for junior researchers and clinicians in order to expand their research directions in chronic diseases. We will recruit geneticists and train them with the knowledge and skills for epidemiologic and clinical research and recruit epidemiologists and clinical researchers and train them with the knowledge and skills for genomic research at Tulane University for 6 months; (3) to initiate a Summer Institute in Gene- Environment Interaction in China and offer short courses in Biostatistics, Epidemiological Methods, Clinical Research Methods, Human Molecular Genetics, Statistical Genetics, Genetic Epidemiology, and Chronic Disease Epidemiology. We will widely publicize this summer institute and make the course materials available online to a wide audience in China; and 4) To organize a special session in Gene-Environment Interaction at the China Heart Congress to promote research in gene-environment interaction. This program takes the "train the trainer" approach, and graduates from this program will play a leadership role in building research and training capacity in gene-environment interaction in chronic diseases in China. PUBLIC HEALTH RELEVANCE: The Research Training in Gene-Environment Interaction in China is a collaborative research training program proposed by the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, the Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and the National Center for Cardiovascular Disease of China. This multidisciplinary training program aims to build capacity for future genomic, epidemiological, and clinical research and training in chronic diseases in China and to strengthen partnerships between the US and Chinese investigators by training the leaders and the next generation of scientists in gene-environment interaction research.

描述(申请人提供)：这是美国洛杉矶新奥尔良杜兰大学公共卫生与热带医学院、中国医学科学院心血管研究所、北京协和医院心血管研究所、北京协和医院心血管病研究所、中国国家心血管疾病中心针对《计划公告：慢性非传染性疾病与终身疾病：福格蒂国际研究培训奖》(D43)提出的联合申请，旨在为中国提供终身慢性病基因与环境相互作用的研究培训。大多数慢性、非传染性疾病和障碍很可能是由遗传易感性、环境暴露及其相互作用决定的。这一多学科培训计划建立在美国和中国参与机构在慢性病研究方面的长期合作基础上，旨在加强中国慢性病基因-环境相互作用研究的能力。具体目标是：(1)为在北京协和医学院攻读博士学位的研究生建立一个独特的跨学科项目，重点是多学科研究培训，旨在研究中国慢性病中的基因变异、环境暴露及其相互作用。在中国的北京邮电大学完成第一年的课程工作后，学员将在美国杜兰大学的第二年参加遗传学、统计学、流行病学和临床研究方法方面的高级课程，并获得人口或实验室研究方面的经验。学员将在北京理工大学和杜兰大学教职员工的共同指导下，在中国进行论文研究。他们将在北京医科大学获得博士学位；(2)为初级研究人员和临床医生提供基因与环境相互作用的多学科博士后研究培训，以扩大他们在慢性病方面的研究方向。我们将招聘遗传学家，对他们进行流行病学和临床研究的知识和技能培训，并在杜兰大学招聘流行病学和临床研究人员，对他们进行为期6个月的基因组研究知识和技能培训；(3)在中国创办基因与环境相互作用暑期研究所，开设生物统计学、流行病学方法、临床研究方法、人类分子遗传学、统计遗传学、遗传流行病学和慢性病流行病学等短期课程。我们将广泛宣传这个暑期研究所，并将课程材料在线提供给中国的广大受众；4)在中国心脏大会上组织基因与环境相互作用专题会议，促进基因与环境相互作用的研究。该项目采取了培养培训师的方式，该项目的毕业生将在中国慢性病基因-环境相互作用的研究和培训能力建设方面发挥带头作用。 公共卫生相关性：中国基因-环境相互作用研究培训是由美国洛杉矶新奥尔良杜兰大学公共卫生与热带医学院、中国医学科学院心血管研究所、北京协和医院心血管研究所、北京协和医院、中国国家心血管疾病中心提出的合作研究培训项目。这一多学科培训计划旨在建设中国未来在慢性病方面的基因组、流行病学和临床研究和培训的能力，并通过培训基因-环境相互作用研究的领导者和下一代科学家来加强美中研究人员之间的合作伙伴关系。