Research Training in Gene-Environment Interaction in China

简介（由申请人提供）：根据项目公告，由美国新奥尔良杜兰大学公共卫生与热带医学院、中国医学科学院、北京协和医学院心血管研究所、阜外医院和中国国家心血管疾病中心联合申请在中国开展慢性疾病全寿命期基因-环境相互作用研究培训：慢性、非传染性疾病和终身障碍：福格蒂国际研究培训奖（非传染性疾病-终身疾病）（D43）。大多数慢性非传染性疾病和失调可能是由遗传易感性、环境暴露及其相互作用决定的。该多学科培训项目建立在中美两国参与机构在慢性病研究方面长期合作的基础上，旨在加强中国慢性病基因-环境相互作用研究的能力。具体目标是：(1)为北京协和医学院（PUMC）的博士研究生建立一个独特的跨学科项目，重点研究中国慢性疾病的遗传变异、环境暴露及其相互作用。在完成第一年的课程学习后，学员将在美国杜兰大学学习遗传学、统计学、流行病学和临床研究方法方面的高级课程，并在人口或实验室研究方面积累经验。受训者将在PUMC和杜兰大学的共同指导下在中国进行论文研究。他们将在北大获得博士学位；(2)为初级科研人员和临床医生提供多学科的基因-环境相互作用的博士后研究培训，以拓展他们在慢性疾病方面的研究方向。我们将招募遗传学家对他们进行流行病学和临床研究的知识和技能培训招募流行病学家和临床研究人员对他们进行为期6个月的基因组研究知识和技能培训；(3)在中国开办基因与环境相互作用暑期研究所，开设生物统计学、流行病学方法、临床研究方法、人类分子遗传学、统计遗传学、遗传流行病学、慢性病流行病学等短期课程。我们将广泛宣传这个暑期课程，并将课程资料在网上提供给中国广大的受众；4)在中国心脏大会上组织“基因与环境相互作用”专题会议，推动基因与环境相互作用的研究。该项目采用“培养培训师”的方式，毕业生将在中国慢性病基因-环境相互作用的研究和培训能力建设中发挥领导作用。

DESCRIPTION (provided by applicant): This is a joint application of the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, the Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and the National Center for Cardiovascular Diseases of China to provide research training in gene-environment interaction in chronic diseases across the lifespan in China in response to Program Announcement: Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43). Most chronic, non-communicable diseases and disorders are likely determined by genetic predisposition, environmental exposure and their interactions. This multidisciplinary training program is built on the long- standing collaboration in chronic disease research between the US and Chinese participating institutes and aims to strengthen capacity for gene-environment interaction research in chronic diseases in China. The specific aims are: (1) to establish a unique, interdisciplinary program for graduate students pursuing doctoral degrees at the Peking Union Medical College (PUMC), with a strong emphasis on multidisciplinary research training designed to study genetic variation, environmental exposure, and their interactions in chronic diseases in China. After the first year of course work at PUMC in China, the trainees will take advanced courses in genetics, statistics, epidemiology and clinical research methods, as well as gain experience in population or laboratory research, during their second year at Tulane University in the US. The trainees will conduct their dissertation research in China under co-mentorship from faculty at PUMC and Tulane. They will receive their doctoral degrees from PUMC; (2) To provide multidisciplinary postdoctoral research training in gene- environment interaction for junior researchers and clinicians in order to expand their research directions in chronic diseases. We will recruit geneticists and train them with the knowledge and skills for epidemiologic and clinical research and recruit epidemiologists and clinical researchers and train them with the knowledge and skills for genomic research at Tulane University for 6 months; (3) to initiate a Summer Institute in Gene- Environment Interaction in China and offer short courses in Biostatistics, Epidemiological Methods, Clinical Research Methods, Human Molecular Genetics, Statistical Genetics, Genetic Epidemiology, and Chronic Disease Epidemiology. We will widely publicize this summer institute and make the course materials available online to a wide audience in China; and 4) To organize a special session in Gene-Environment Interaction at the China Heart Congress to promote research in gene-environment interaction. This program takes the "train the trainer" approach, and graduates from this program will play a leadership role in building research and training capacity in gene-environment interaction in chronic diseases in China.