Novel strategies for stroke rehabilitation (planning grant)

中风康复新策略（规划拨款）

• 批准号: 8319998
• 负责人: ADRIANA B CONFORTO
• 金额: $ 2.92万
• 依托单位: FUNDACAO FACULDADE DE MEDICINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319998
• 关键词: Animals; Applications Grants; Biomedical Engineering; Brazil; Cerebrovascular Disorders; Clinic; Clinical; Collaborations; Country; Education; Electric Stimulation; Equipment; Funding; Future; Grant; Healthcare; Hospitals; Human; Human Resources; Income; Independent Living; Institution; Intervention; Laboratories; Mentors; National Institute of Neurological Disorders and Stroke; Neurologic; Neurons; Neurosciences; Operative Surgical Procedures; Physiology; Protocols documentation; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Staging; Stroke; Structure; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Work; design; disability; evidence base; experience; global health; neuroregulation; neurosurgery; novel strategies; professor; programs; restoration; skills; stroke rehabilitation

DESCRIPTION (provided by applicant): Title: Novel strategies for stroke rehabilitation Cerebrovascular disease is the #1 cause of disability in western countries. The catastrophic burden of stroke and the scarcity of evidence-based rehabilitation interventions represent a major challenge to global health care. There is a gap between the massive impact of disability from stroke, studies in animals demonstrating "rewiring" of neuronal circuits and availability of neurorehabilitative strategies to restore independent living in the clinical domain. Basic infrastructure to implement research in stroke rehabilitation has been developed at the Neurostimulation Laboratory at Hospital das Clmnicas/ Sao Paulo University, Brazil, in great part due to a previous NIH-funded grant. However there is a lack of skilled human resources to move the research forward. This grant proposal aims to plan a training program that will provide skills in neuroscience, stroke rehabilitation, neuromodulation and biomedical engineering that will nurture novel strategies to decrease disability from stroke. The P.I., Dr. Conforto, chief of the Neurostimulatation Laboratory, will collaborate with Dr. Leonardo Cohen, a senior researcher that leads the Human Cortical Physiology and Stroke Rehabilitation Section at Intramural NINDS, with Dr. P. Hunter Peckham, a distinguished researcher and pioneer on functional electrical stimulation, who is Professor of Biomedical Engineering at the Case Western Reserve University and with Dr. Andre Machado, Director of the Center for Neurological Restoration and Assistant Professor of Surgery in the Neurosurgery Department at the Cleveland Clinic, who leads rehabilitation protocols and who was mentored by Dr. Conforto at Sao Paulo in the past. In addition, Dr. Suely Marie, an eminent senior Brazilian researcher at Sao Paulo University with extensive experience in training research personnel and in participating in multicenter collaborations, will assist the P.I. in adapting the training program to local conditions. During the grant, researchers from the institution in the middle-income country (Brazil) and the high-income institutions in the United States will work together to identify creative, effective mechanisms to enhance research capability at the Neurostimulation Laboratory. We will design and test a preliminary, structured training program that includes theoretical and practical activities, and that until now has never been implemented in the middle-income institution. Adjustments will be made, and results of the program will be thoroughly and objectively evaluated to prepare a comprehensive training program for a future D-43 grant application proposal. The collaboration between Sao Paulo University, Intramural NINDS, Case Western Reserve University and Cleveland Clinic will set the stage for advancing education in non invasive cortical neuromodulation and biomedical engineering, needed to ripen strategies for stroke rehabilitation. Equipment and facilities are available at the middle-income country institution that will provide full support to this planning grant proposal.

描述（由申请人提供）：标题：中风康复的新策略脑血管疾病是西方国家残疾的头号原因。中风的灾难性负担和缺乏循证康复干预措施是全球卫生保健面临的主要挑战。在中风造成的残疾的巨大影响、证明神经元回路“重新布线”的动物研究和恢复临床领域独立生活的神经康复策略的可用性之间存在差距。巴西圣保罗大学医院的神经刺激实验室开发了实施中风康复研究的基本基础设施，这在很大程度上是由于之前NIH资助的赠款。然而，缺乏熟练的人力资源来推动研究。这项拨款提案旨在计划一项培训计划，该计划将提供神经科学，中风康复，神经调节和生物医学工程方面的技能，这些技能将培养减少中风残疾的新策略。私家侦探，Conforto博士，神经刺激实验室主任，将与列奥纳多科恩博士，高级研究员，领导人类皮层生理学和中风康复科在Intramural NINDS，与P亨特佩卡姆博士，一位杰出的研究员和先驱的功能性电刺激，谁是生物医学工程教授在凯斯西储大学和安德烈马查多博士，克利夫兰诊所神经外科神经恢复中心主任和外科助理教授，他领导康复方案，过去曾在圣保罗接受Conforto博士的指导。此外，圣保罗大学杰出的巴西高级研究员Suely玛丽博士在培训研究人员和参与多中心合作方面具有丰富的经验，他将协助P.I.使培训计划适应当地条件。在赠款期间，来自中等收入国家（巴西）和美国高收入机构的研究人员将共同努力，确定创造性的有效机制，以提高神经刺激实验室的研究能力。我们将设计和测试一个初步的，结构化的培训计划，其中包括理论和实践活动，直到现在还没有在中等收入机构实施。将作出调整，并将对该计划的结果进行全面和客观的评估，为未来的D-43赠款申请提案准备一个全面的培训计划。圣保罗大学、Intramural NINDS、凯斯西储大学和克利夫兰诊所之间的合作将为推进非侵入性皮质神经调节和生物医学工程的教育奠定基础，这是中风康复策略成熟所需的。中等收入国家的机构有设备和设施，将为这项规划赠款提案提供充分支助。