Novel strategies for stroke rehabilitation (planning grant)

中风康复新策略（规划拨款）

• 批准号: 8185226
• 负责人: ADRIANA B CONFORTO
• 金额: $ 2.92万
• 依托单位: FUNDACAO FACULDADE DE MEDICINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185226
• 关键词: Animals; Applications Grants; Biomedical Engineering; Brazil; Cerebrovascular Disorders; Clinic; Clinical; Collaborations; Country; Education; Electric Stimulation; Equipment; Funding; Future; Grant; Healthcare; Hospitals; Human; Human Resources; Income; Independent Living; Institution; Intervention; Laboratories; Mentors; National Institute of Neurological Disorders and Stroke; Neurologic; Neurons; Neurosciences; Operative Surgical Procedures; Physiology; Protocols documentation; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Staging; Stroke; Structure; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Work; design; disability; evidence base; experience; global health; neuroregulation; neurosurgery; novel strategies; professor; programs; restoration; skills; stroke rehabilitation

DESCRIPTION (provided by applicant): Title: Novel strategies for stroke rehabilitation Cerebrovascular disease is the #1 cause of disability in western countries. The catastrophic burden of stroke and the scarcity of evidence-based rehabilitation interventions represent a major challenge to global health care. There is a gap between the massive impact of disability from stroke, studies in animals demonstrating "rewiring" of neuronal circuits and availability of neurorehabilitative strategies to restore independent living in the clinical domain. Basic infrastructure to implement research in stroke rehabilitation has been developed at the Neurostimulation Laboratory at Hospital das Clmnicas/ Sao Paulo University, Brazil, in great part due to a previous NIH-funded grant. However there is a lack of skilled human resources to move the research forward. This grant proposal aims to plan a training program that will provide skills in neuroscience, stroke rehabilitation, neuromodulation and biomedical engineering that will nurture novel strategies to decrease disability from stroke. The P.I., Dr. Conforto, chief of the Neurostimulatation Laboratory, will collaborate with Dr. Leonardo Cohen, a senior researcher that leads the Human Cortical Physiology and Stroke Rehabilitation Section at Intramural NINDS, with Dr. P. Hunter Peckham, a distinguished researcher and pioneer on functional electrical stimulation, who is Professor of Biomedical Engineering at the Case Western Reserve University and with Dr. Andre Machado, Director of the Center for Neurological Restoration and Assistant Professor of Surgery in the Neurosurgery Department at the Cleveland Clinic, who leads rehabilitation protocols and who was mentored by Dr. Conforto at Sao Paulo in the past. In addition, Dr. Suely Marie, an eminent senior Brazilian researcher at Sao Paulo University with extensive experience in training research personnel and in participating in multicenter collaborations, will assist the P.I. in adapting the training program to local conditions. During the grant, researchers from the institution in the middle-income country (Brazil) and the high-income institutions in the United States will work together to identify creative, effective mechanisms to enhance research capability at the Neurostimulation Laboratory. We will design and test a preliminary, structured training program that includes theoretical and practical activities, and that until now has never been implemented in the middle-income institution. Adjustments will be made, and results of the program will be thoroughly and objectively evaluated to prepare a comprehensive training program for a future D-43 grant application proposal. The collaboration between Sao Paulo University, Intramural NINDS, Case Western Reserve University and Cleveland Clinic will set the stage for advancing education in non invasive cortical neuromodulation and biomedical engineering, needed to ripen strategies for stroke rehabilitation. Equipment and facilities are available at the middle-income country institution that will provide full support to this planning grant proposal. PUBLIC HEALTH RELEVANCE: Cerebrovascular disease is the #1 cause of disability in western countries. The catastrophic burden of stroke and the scarcity of evidence-based rehabilitation interventions represent a major challenge to global health care. This planning grant will set the stage for advancing education in research in order to develop game-changer strategies for stroke rehabilitation.

描述(申请人提供)：标题：中风康复的新策略脑血管疾病是西方国家导致残疾的头号原因。中风的灾难性负担和缺乏循证康复干预措施是全球卫生保健面临的重大挑战。在中风致残的巨大影响、对动物的研究表明神经元回路的“重新连接”与恢复临床领域独立生活的神经康复策略的可用性之间存在差距。巴西圣保罗大学克拉姆尼卡斯医院的神经刺激实验室已经建立了实施中风康复研究的基本基础设施，这在很大程度上要归功于之前由NIH资助的一笔赠款。然而，缺乏熟练的人力资源来推动这项研究。这项赠款提案旨在规划一项培训计划，该计划将提供神经科学、中风康复、神经调节和生物医学工程方面的技能，以培育减少中风致残的新策略。私家侦探、神经刺激实验室主任康福尔托博士将与内壁NINDS人类皮质生理学和中风康复科的高级研究员莱昂纳多·科恩博士、凯斯西储大学生物医学工程教授、功能电刺激领域的杰出研究员和先驱P·亨特·佩卡姆博士以及克利夫兰诊所神经外科神经外科主任兼外科助理教授安德烈·马查多博士合作，康福尔托博士是康复方案的负责人，过去曾在圣保罗接受康福托博士的指导。此外，圣保罗大学著名的巴西高级研究员Suely Marie博士在培训研究人员和参与多中心合作方面拥有丰富的经验，他将协助P.I.根据当地情况调整培训计划。在赠款期间，来自中等收入国家(巴西)机构和美国高收入机构的研究人员将共同努力，确定创造性的有效机制，以提高神经刺激实验室的研究能力。我们将设计和测试一个初步的、结构化的培训计划，包括理论和实践活动，而到目前为止，这些培训计划从未在中等收入机构实施过。将进行调整，并将彻底和客观地评估该计划的结果，为未来的D-43拨款申请提案准备一个全面的培训计划。圣保罗大学、INTERNAL NINDS、凯斯西储大学和克利夫兰诊所之间的合作将为推进非侵入性皮质神经调节和生物医学工程方面的教育奠定基础，这是成熟中风康复策略所必需的。中等收入国家机构提供了设备和设施，将为这项规划赠款提议提供充分支持。 公共卫生相关性：在西方国家，脑血管疾病是导致残疾的头号原因。中风的灾难性负担和缺乏循证康复干预措施是全球卫生保健面临的重大挑战。这笔规划拨款将为推动研究教育，为中风康复制定改变游戏规则的战略奠定基础。