Text Messaging to Improve Adherence to Oral Chemotherapy Agents

通过短信提高口服化疗药物的依从性

• 批准号: 8496241
• 负责人: Sandra Lee Spoelstra
• 金额: $ 46.46万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496241
• 关键词: 21 year old; Academic Research Enhancement Awards; Adherence; Age; Antineoplastic Agents; Area; Behavioral; Cancer Center; Cancer Patient; Caring; Cellular Phone; Clinic; Clinic Visits; Clinical; Colon Carcinoma; Complex; Control Groups; Data; Diagnostic Neoplasm Staging; Discipline of Nursing; Disease; Dose; Effectiveness; Empirical Research; Enrollment; Environment; Equation; Funding; Goals; Grant; Health; Health Personnel; Home environment; Intervention; Interview; Life; Linear Models; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Marketing; Michigan; Nursing Students; Oncologist; Oral; Outcome; Participant; Patients; Pharmaceutical Preparations; Population; Process; Race; Randomized; Randomized Controlled Trials; Recruitment Activity; Regimen; Research; Research Project Grants; Self Care; Self Efficacy; Services; Severities; Students; Symptoms; Technology; Testing; Text; Therapeutic; Translations; Treatment Efficacy; Treatment Protocols; United States National Institutes of Health; Universities; base; cancer therapy; cancer type; career; chemotherapy; college; cost effective; graduate student; group intervention; improved; innovation; interest; malignant breast neoplasm; malignant mouth neoplasm; member; novel; pill; prospective; public health relevance; randomized trial; satisfaction; sex; statistics; symptom management; therapy development; treatment as usual; undergraduate student

DESCRIPTION (provided by applicant): The purpose of this Academic Research Enhancement Award proposal is to conduct a small-scale, health- related research project on text messages to improve adherence to oral chemotherapy agents. Michigan State University College of Nursing (MSU-CON) has not been a major recipient of National Institute of Health grant funding. As a result, the overall objectiveof this proposal is to strengthen the research environment in the College of Nursing so that it can develop into a significant health-related scientific research enterprise. This project would involv undergraduate and graduate students and, thus, generate student interest in research as a career. The importance of the research planned for this proposal is as follows. More than 50 oral chemotherapy agents in pill form are currently on the market, with projections that in 3 years, 25% of cancer treatments will be delivered in pill form. There are many associated benefits of oral agents, such as convenience, avoidance of clinic visits, and reduced impact on daily activities. For oral agents to achieve a - therapeutically effective level for cancer treatmet, patients must strictly adhere to the regimen. Adherence to oral cancer agents is often less than 80%, which may be inadequate for treating the cancer. To further complicate this, nearly 75% of those with cancer also have comorbid conditions with self-care management responsibilities, which may create barriers to oral agent adherence. To date, empirical research in the area of improving adherence to oral agents is underdeveloped. The goal of this research is to improve adherence to oral chemotherapy agents through a technology-based strategy: tailored short message service (SMS) text messages. This 10 week, two group, prospective randomized controlled trial will enroll 75 patients (50 in the intervention group and 25 in the control group) from three cancer centers to examine the feasibility, acceptability, and satisfaction with a three week, tailored, text message intervention for oral agent adherence. Descriptive statistics, generalized linear modeling, and generalized estimating equations will be used for analysis. In this proposal, preliminary data will be collected to examine efficacy of the text message intervention to promote adherence to oral agents. Data will then be used to further inform the development of an intervention to improve adherence to oral agents for an R01 application to conduct a larger randomized trial to test this innovative intervention. This study can have a transformative impact on oral agent adherence by developing a technology-based strategy to promote adherence among the increasing number of cancer patients who receive their cancer treatment in pill form. This type of novel intervention also has the potential to transform and impact many other ill populations that require adherence to a medication regimen. Furthermore, this proposal involves numerous nursing students, allowing them to be fully functioning members of a team and engaging them in the research process. This application will strengthen the research environment at MSU- CON so that it can develop into a significant health-related scientific research enterprise.

描述（由申请人提供）：