Clinical Trials Network: Pacific Northwest Node

描述（由申请人提供）：这项由华盛顿大学和华盛顿州立大学（WSU）联合提交的多部门、多机构申请NIDA临床试验网络太平洋西北（PNW）节点的竞争更新，其主要目的是继续该节点对CTN使命的积极支持，即“以科学为载体提高全国药物滥用治疗的质量”，开展行为、药理学、在严格的多地点临床试验中进行联合/综合治疗干预，以确定在广泛的社区治疗环境和多样化的患者群体中的有效性，并确保将研究成果传递给医生、临床医生、提供者、决策者和患者。为了实现这些目标，PNW节点建议：“在我们加入CTN之前，保持/扩大研究人员、药物滥用治疗和保健提供者以及政策制定者之间有效的双向伙伴关系；“维持/扩大我们高度成功、完善的治疗研究基础设施；与ctsa资助的转化健康科学研究所（ITHS）合作，扩大节点的地理覆盖范围，包括WWAMI地区（华盛顿州、怀俄明州、阿拉斯加州、蒙大拿州和爱达荷州）；“通过扩大附属项目的类型，扩大我们对美洲印第安人/阿拉斯加原住民的关注，并通过我们与华盛顿州立大学的农村精神健康和药物滥用治疗卓越项目的合作，将重点放在农村社区/项目上，从而扩大节点的种族和人口多样性；通过增加一些规模更大、研究经验丰富、以医学和精神病学为重点的伙伴组织，以补充我们所属的以社区为基础的药物滥用治疗方案，加强该节点开展试验的能力，并更迅速地对不断变化和新出现的公共卫生优先事项作出反应；“通过增加一些新的附属调查员来增强节点的临床研究专业知识；“扩大该节点的传播合作伙伴网络，以便向更广泛的地理和专业服务提供者提供研究翻译和培训，特别是在初级保健和农村环境中。这种新的结构将使我们能够利用我们所取得的进展，并使我们能够在未来继续为CTN的使命作出重大贡献。

DESCRIPTION (provided by applicant): This multiple-Pi, multiple-institution application for the competing renewal of the Pacific Northwest (PNW) Node of the NIDA Clinical Trials Network, submitted jointly by the University of Washington and Washington State University (WSU), has the primary aim of continuing the Node's active support of the CTN's mission to "improve the quality of drug abuse treatment throughout the country using science as the vehicle", to conduct studies of the therapeutic effect of behavioral, pharmacological, and combined/integrated treatment interventions in rigorous, multi-site clinical trials to determine effectiveness across a broad range of community-based treatment settings and diversified patient populations, and to ensure the transfer of research results to physicians, clinicians, providers, policy makers, and patients. To meet these objectives, the PNW Node proposes to: 'Maintain/expand the effective, bidirectional partnerships among researchers, substance abuse treatment and healthcare providers, and policy makers that predate our entry into the CTN; 'Maintain/expand our highly successful, well-established treatment research infrastructure; 'Expand the Node's geographical reach, working with the CTSA-funded Institute of Translational Health Sciences (ITHS), to include the WWAMI region (Washington, Wyoming, Alaska, Montana, and Idaho); 'Expand the Node's ethnic and demographic diversity by broadening the types of affiliated programs, expanding our focus on American Indians/Alaska Natives, and concentrating on rural communities/programs through our partnership with WSU's Program of Excellence on Rural Mental Health and Substance Abuse Treatment; Enhance the Node's capacity to conduct trials and respond more rapidly to shifting and emerging public health priorities by adding a number of larger, highly research-experienced, medically and psychiatrically focused partner organizations to complement our affiliated community-based substance abuse treatment programs; 'Augment the clinical research expertise of the Node by adding a number of new affiliated Investigators; 'Expand the Node's network of dissemination partners in order to provide research translation and training to a wider geographic and professional audience of providers, especially in primary care and rural settings. This new structure will allow us to capitalize on progress we have made and will enable us to continue to make significant contributions to the CTN's mission in the future.