CLINICAL TRIALS NETWORK: PACIFIC NORTHWEST NODE

临床试验网络：太平洋西北节点

• 批准号: 6626826
• 负责人: DENNIS Michael DONOVAN
• 金额: $ 150万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-10 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6626826
• 关键词: clinical research; clinical trials; combination therapy; cooperative study; drug abuse chemotherapy; drug abuse therapy; health care policy; health care service availability; human subject; human therapy evaluation; interdisciplinary collaboration

DESCRIPTION: (Applicant's Abstract) Drug dependence continues to be a persistent problem for which new treatments, both behavioral and pharmacological, are continually being developed. There is a great need to develop mechanisms by which such treatments, once shown to be efficacious, can be put into widespread clinical practice in community-based treatment programs where the largest number of drug abusers are seen. A number of barriers between researchers and clinicians, however, have made such a transition difficult, if at all possible. The recent Institute of Medicine report has challenged us to work on "bridging the gap," to address the barriers to facilitate a more functional working relationship between treatment providers and clinical researchers, who share a common goal of wanting to improve substance abuse treatment and its outcomes. NIDA has developed an action agenda to stimulate treatment providers and researchers to consider ways, from each of their perspectives, to narrow or bridge the "gap." NIDA's action agenda is the development of the National Clinical Trials Network (CTN), in which researchers at Regional Research and Training Centers work in partnership with Community-based Treatment Programs both to develop areas of mutual interest for future clinical research and to test promising therapies in community settings. The present proposal seeks support to develop the Pacific Northwest (PNW) Regional Research and Training Center of the NIDA-funded Clinical Trials Network. The interdisciplinary Regional Research and Training Center, to be housed within the University of Washington Alcohol and Drug Abuse Institute (ADAI), will have as its primary focus the development, implementation, and evaluation of behavioral and pharmacological therapies, alone and in combination, targeted at drug use as delivered in the real world settings of the affiliated community-based treatment programs. It will integrate behavioral and pharmacological research as a means of informing policy, therapy development, and the evaluation process, with a goal of contributing meaningfully to the improved effectiveness of new and promising therapies developed within the larger Clinical Trials Network. The investigators have a long history of working with community based programs in research and program evaluation, collaborating on multisite clinical trials, developing and evaluating both pharmacotherapy and behavioral therapy, and conducting services research, and translating and disseminating results into information useful for clinicians and policy makers. It is this experience that we offer to the larger Clinical Trials Network.

产品说明：（申请人的摘要）药物依赖性仍然是一个持续存在的问题，对于该问题，正在不断开发新的治疗方法，包括行为治疗和药理治疗。非常需要开发机制，使这些治疗一旦被证明有效，就可以在药物滥用人数最多的社区治疗方案中投入广泛的临床实践。然而，研究人员和临床医生之间的一些障碍使得这种转变变得困难，如果可能的话。最近的医学研究所报告向我们提出了挑战，要求我们致力于“弥合差距”，以解决障碍，促进治疗提供者和临床研究人员之间更有效的工作关系，他们有一个共同的目标，即希望改善药物滥用治疗及其结果。NIDA制定了一项行动议程，以激励治疗提供者和研究人员从各自的角度考虑缩小或弥合“差距”的方法。“NIDA的行动议程是国家临床试验网络（CTN）的发展，其中区域研究和培训中心的研究人员与社区治疗计划合作，为未来的临床研究开发共同感兴趣的领域，并在社区环境中测试有前途的疗法。目前的提案寻求支持，以发展NIDA资助的临床试验网络的太平洋西北地区（PNW）区域研究和培训中心。跨学科的区域研究和培训中心，将设在华盛顿酒精和药物滥用研究所（ADAI）的大学，将有其主要重点的发展，实施和评估的行为和药理学疗法，单独和组合，针对药物的使用，在真实的世界设置提供的附属社区为基础的治疗方案。它将整合行为和药理学研究，作为告知政策，治疗开发和评估过程的一种手段，其目标是为更大的临床试验网络内开发的新的和有前途的疗法的有效性的提高做出有意义的贡献。研究人员在研究和项目评估中与社区项目合作，在多地点临床试验中合作，开发和评估药物治疗和行为治疗，进行服务研究，并将结果翻译和传播为对临床医生和政策制定者有用的信息。这是我们为更大的临床试验网络提供的经验。