CLINICAL TRIALS NETWORK: PACIFIC NORTHWEST NODE

描述：(申请人摘要)药物依赖仍然是一个持续存在的问题，人们正在不断地开发新的治疗方法，包括行为和药物治疗。非常需要制定机制，使这种一旦被证明有效的治疗方法能够在吸毒者人数最多的社区治疗方案中广泛应用于临床实践。然而，研究人员和临床医生之间的许多障碍使得这种过渡变得困难，如果可能的话。医学研究所最近的报告向我们提出了挑战，要求我们努力“弥合差距”，解决障碍，以促进治疗提供者和临床研究人员之间更具功能性的工作关系，他们的共同目标是希望改善药物滥用治疗及其结果。NIDA已经制定了一项行动议程，以鼓励治疗提供者和研究人员从他们的每个角度考虑缩小或弥合“差距”的方法。NIDA的行动议程是发展国家临床试验网络(CTN)，在该网络中，区域研究和培训中心的研究人员与社区治疗计划合作，为未来的临床研究开发共同感兴趣的领域，并在社区环境中测试有前景的治疗方法。本提案寻求支持发展NIDA资助的临床试验网络的太平洋西北(PNW)区域研究和培训中心。将设在华盛顿大学酒精和药物滥用研究所(ADAI)内的跨学科区域研究和培训中心将把开发、实施和评估单独或联合针对药物使用的行为和药物疗法作为其主要重点，这些疗法针对的是在附属社区治疗计划的现实世界中提供的药物使用。它将整合行为和药理学研究，作为告知政策、治疗开发和评估过程的一种手段，目标是为在更大的临床试验网络内开发的新的和有前途的疗法的有效性做出有意义的贡献。研究人员在研究和方案评估方面与社区项目合作有很长的历史，在多点临床试验中合作，开发和评估药物疗法和行为疗法，进行服务性研究，并将结果转化和传播为对临床医生和政策制定者有用的信息。我们向更大的临床试验网络提供的正是这种体验。

DESCRIPTION: (Applicant's Abstract) Drug dependence continues to be a persistent problem for which new treatments, both behavioral and pharmacological, are continually being developed. There is a great need to develop mechanisms by which such treatments, once shown to be efficacious, can be put into widespread clinical practice in community-based treatment programs where the largest number of drug abusers are seen. A number of barriers between researchers and clinicians, however, have made such a transition difficult, if at all possible. The recent Institute of Medicine report has challenged us to work on "bridging the gap," to address the barriers to facilitate a more functional working relationship between treatment providers and clinical researchers, who share a common goal of wanting to improve substance abuse treatment and its outcomes. NIDA has developed an action agenda to stimulate treatment providers and researchers to consider ways, from each of their perspectives, to narrow or bridge the "gap." NIDA's action agenda is the development of the National Clinical Trials Network (CTN), in which researchers at Regional Research and Training Centers work in partnership with Community-based Treatment Programs both to develop areas of mutual interest for future clinical research and to test promising therapies in community settings. The present proposal seeks support to develop the Pacific Northwest (PNW) Regional Research and Training Center of the NIDA-funded Clinical Trials Network. The interdisciplinary Regional Research and Training Center, to be housed within the University of Washington Alcohol and Drug Abuse Institute (ADAI), will have as its primary focus the development, implementation, and evaluation of behavioral and pharmacological therapies, alone and in combination, targeted at drug use as delivered in the real world settings of the affiliated community-based treatment programs. It will integrate behavioral and pharmacological research as a means of informing policy, therapy development, and the evaluation process, with a goal of contributing meaningfully to the improved effectiveness of new and promising therapies developed within the larger Clinical Trials Network. The investigators have a long history of working with community based programs in research and program evaluation, collaborating on multisite clinical trials, developing and evaluating both pharmacotherapy and behavioral therapy, and conducting services research, and translating and disseminating results into information useful for clinicians and policy makers. It is this experience that we offer to the larger Clinical Trials Network.