Prenatal Methamphetamine Exposure and School Aged Outcome

产前甲基苯丙胺暴露和学龄结果

• 批准号: 8627933
• 负责人: Barry M. Lester
• 金额: $ 17.27万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8627933
• 关键词: 3 year old; Affect; Age; Area; Arousal; Attention; Behavior; Biological Neural Networks; Birth; Blood flow; Brain; California; Child; Clinical; Cocaine; Conflict (Psychology); Data Collection; Development; Drug Exposure; Drug abuse; Environment; Failure; Family; Fetal Growth; Hair; Hawaii; Home environment; Infant; Infant Development; Iowa; Judgment; Learning; Legal; Life Style; Literature; Mediating; Memory; Methamphetamine; Motivation; Motor; Oklahoma; Outcome; Perfusion; Pharmaceutical Preparations; Policies; Population Heterogeneity; Pregnancy; Pregnant Women; Publishing; Regulation; Research; Research Personnel; Risk Factors; Role; School-Age Population; Schools; Site; Smoke; Societies; Structure; Sympathetic Nervous System; Symptoms; Textiles; Treatment/Psychosocial Effects; United States; United States National Institutes of Health; Woman; Work; base; brain metabolism; caregiving; cohort; dopamine transporter; drug development; executive function; fetal methamphetamine exposure; fetus hypoxia; follow-up; methamphetamine abuse; methamphetamine exposure; motor control; motor learning; neuroimaging; neurotoxic; novel; policy implication; postnatal; pre-clinical; preclinical study; programs; prospective; psychosocial; response; skills; visual-motor integration

DESCRIPTION (provided by applicant): The rapidly escalating abuse of methamphetamine (METH) in the United States, places a sense of urgency on understanding the consequences of METH use during pregnancy for the developing child. To our knowledge, IDEAL (Infant Development Environment and Lifestyle) is the only prospective longitudinal NIH study of prenatal Methamphetamine exposure and child outcome. This is a competitive renewal application for the 4-7 year follow-up of the IDEAL cohort. The IDEAL data collection sites are from diverse populations in Iowa, Oklahoma, California, and Hawaii where METH use by pregnant women is prevalent. We have followed 204 Methamphetamine exposed and 208 Comparison children since birth who are now completing assessments at 24 and 30 months. Here, we propose a 4-7 year follow-up, an important age range when executive function neural networks develop and children make the critical transition to school. Our plan is to study a relatively narrow band of executive function domains outcomes supported by the published preclinical and clinical literature and our own preliminary findings. We also plan to study how these executive function domains affect school related academic skills. Our preliminary findings show effects of prenatal Methamphetamine exposure on fetal growth, and on behavior between birth and 3 years on arousal-regulation, attention, inhibitory control, motivation and motor control with some effects due to heavy Methamphetamine exposure. These effects suggest that motor development and precursors of executive function may be affected by prenatal Methamphetamine exposure. We also found effects of psychosocial risk factors including low SES, family conflict, maternal psychiatric status and abuse potential, and out of home placement. In this application, we plan to study the effects of prenatal Methamphetamine exposure on emerging executive function domains including higher order motivation, attention, memory, inhibitory control, visual motor integration, and motor control, and how the effects of prenatal Methamphetamine exposure are affected by psychosocial risk factors and by postnatal passive drug exposure (e.g. smoke).

描述（由申请人提供）：美国甲基苯丙胺 (METH) 的滥用迅速升级，迫切需要了解怀孕期间使用甲基苯丙胺 (METH) 对发育中的孩子造成的后果。据我们所知，IDEAL（婴儿发育环境和生活方式）是 NIH 唯一一项关于产前甲基苯丙胺暴露和儿童结局的前瞻性纵向研究。这是针对 IDEAL 队列 4-7 年随访的竞争性续签申请。 IDEAL 数据收集站点来自爱荷华州、俄克拉荷马州、加利福尼亚州和夏威夷州的不同人群，这些地区孕妇使用冰毒的情况很普遍。我们自出生起就追踪了 204 名暴露于甲基苯丙胺的儿童和 208 名对照儿童，他们现在正在 24 个月和 30 个月大时完成评估。在这里，我们建议进行 4-7 年的随访，这是执行功能神经网络发育和儿童向学校过渡的重要年龄范围。我们的计划是研究相对狭窄的执行功能领域结果，并得到已发表的临床前和临床文献以及我们自己的初步研究结果的支持。我们还计划研究这些执行功能领域如何影响学校相关的学术技能。我们的初步研究结果表明，产前接触甲基苯丙胺对胎儿生长以及出生至 3 岁之间的行为的唤醒调节、注意力、抑制控制、动机和运动控制的影响，其中一些影响是由于大量接触甲基苯丙胺而产生的。这些影响表明运动发育和执行功能的前体可能会受到产前甲基苯丙胺暴露的影响。我们还发现社会心理风险因素的影响，包括社会经济地位低、家庭冲突、母亲精神状况和虐待可能性以及外出安置。在本申请中，我们计划研究产前甲基苯丙胺暴露对新兴执行功能领域的影响，包括高阶动机、注意力、记忆、抑制控制、视觉运动整合和运动控制，以及产前甲基苯丙胺暴露的影响如何受到心理社会危险因素和产后被动药物暴露（例如烟雾）的影响。

项目成果

Prenatal methamphetamine exposure, home environment, and primary caregiver risk factors predict child behavioral problems at 5 years.

产前甲基苯丙胺暴露、家庭环境和主要照顾者危险因素可预测儿童 5 岁时的行为问题。

• DOI: 10.1111/ajop.12007
• 发表时间: 2013
• 期刊: The American journal of orthopsychiatry
• 作者: Twomey,Jean;LaGasse,Linda;Derauf,Chris;Newman,Elana;Shah,Rizwan;Smith,Lynne;Arria,Amelia;Huestis,Marilyn;DellaGrotta,Sheri;Roberts,Mary;Dansereau,Lynne;Neal,Charles;Lester,Barry
• 通讯作者: Lester,Barry

New meconium biomarkers of prenatal methamphetamine exposure increase identification of affected neonates.

产前甲基苯丙胺暴露的新胎粪生物标志物增加了受影响新生儿的识别。

• DOI: 10.1373/clinchem.2009.139055
• 发表时间: 2010
• 期刊: Clinical chemistry
• 影响因子: 9.3
• 作者: Gray,TeresaR;Kelly,Tamsin;LaGasse,LindaL;Smith,LynneM;Derauf,Chris;Grant,Penny;Shah,Rizwan;Arria,Amelia;Haning,William;DellaGrotta,Sheri;Strauss,Arthur;Lester,BarryM;Huestis,MarilynA
• 通讯作者: Huestis,MarilynA

Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition.

• DOI: 10.1037/a0030157
• 发表时间: 2013-09
• 期刊: PSYCHOLOGY OF ADDICTIVE BEHAVIORS
• 影响因子: 3.4
• 作者: Abar, Beau;LaGasse, Linda L.;Derauf, Chris;Newman, Elana;Shah, Rizwan;Smith, Lynne M.;Arria, Amelia;Huestis, Marilyn;Della Grotta, Sheri;Dansereau, Lynne M.;Neal, Charles;Lester, Barry M.
• 通讯作者: Lester, Barry M.