Multi-modal Neuroimaging Training Program

描述（申请人提供）：体内成像技术取得了巨大进展，使神经科学家能够可视化分子、细胞和系统生理学和功能。为了充分利用神经成像技术，重要的是要了解基本原理，数据检测，数据建模和可视化。此外，每种技术都有自己的优势和局限性。为了培养学生多种互补的神经影像学模式的协同作用，我们建议继续由匹兹堡大学和卡内基梅隆大学联合举办的多模式神经影像学培训计划（MNTP），其中包括博士前研究生课程和短期为期6周的夏季研讨会。现有的认知神经基础研究生课程中心内的MNTP研究生课程具有以下具体目标：1）所有参与学科的学生都接受综合神经成像研究的基础神经科学培训。2)学生了解MRI、扩散张量成像、功能性MRI、正电子发射断层扫描、脑磁图、脑电图、功能性近红外光谱和光学成像的基本原理、建模和应用。3)学生整合多种方法并开展多模式神经成像项目。除了博士前的T90/R90计划，短期MNTP夏季研讨会建议继续提供为期六周的计划，以教授多模态神经成像的协同作用，以有针对性的学生和研究人员谁在一个成像模式的经验，并希望扩大他们的培训到其他模式。暑期课程将包括基本讲座，动手团队项目，成像项目的整合，以及多模式研讨会，强调多种成像模式的方法。在上一个资助期间，这个独特的夏季计划得到了很好的发展。我们的暑期课程使学员能够利用协同，互补的成像方式来调查神经科学问题。短期计划有以下具体目标：1）确保所有参与培训的学员了解几种技术的基本原理，潜力和局限性。2)确保学员学习如何设计范例，收集和处理神经影像学数据，并解释他们的结果。3)确保受训者将多种方法协同整合，并在其所在机构开展多模态神经成像项目。我们提出的计划将培训研究人员充分处理多模态神经影像数据与各种数据采集和处理方法的知识相结合的日益复杂性，以及适当的解释。这将加速多种成像模式在动物和人类基础和临床神经科学研究中的协同应用。

DESCRIPTION (provided by applicant): There have been great advances in in-vivo imaging techniques, which allow neuroscientists to visualize molecular, cellular and system physiology and functions. To fully utilize neuroimaging techniques, it is important to understand underlying principles, data detection, and data modeling and visualization. Furthermore, each technique has its own strengths and limitations. In order to train students the synergy of multiple complementary neuroimaging modalities, we propose to continue the Multimodal Neuroimaging Training Program (MNTP) jointly run by both the University of Pittsburgh and Carnegie Mellon University, which consists of the pre-doctoral graduate program and a short-term 6-week Summer Workshop. The MNTP graduate program within the existing Center for Neural Basis of Cognition Graduate Program has the following specific aims: 1) Students for all participating disciplines receive basic neuroscience training for integrative neuroimaging research. 2) Students understand underlying principles, modeling, and applications of MRI, diffusion tensor imaging, functional MRI, positron emission tomography, magnetoencephalography, electroencephalography, functional near-infrared spectroscopy, and optical imaging. 3) Students integrate multiple methods and carry out multimodal neuroimaging projects. In addition to the pre-doctoral T90/R90 program, a short-term MNTP Summer Workshop is proposed to continue offering the six-week program for teaching the synergy of multi-modal neuroimaging to targeted students and investigators who have experience in one imaging modality and want to expand their training to other modalities. The Summer program will consist of basic lectures, hands-on team projects, integration of imaging projects, and multimodal symposium, emphasizing the methodologies of multiple imaging modalities. During the last funding period, this unique Summer program has been well-developed. Our Summer program enables trainees to utilize synergetic, complementary imaging modalities for investigating neuroscience questions. The short-term program has the following specific aims: 1) To ensure that all participating trainees learn the underlying principles, potentials, and limitations of several technologies. 2) To ensure trainees learn how to design paradigms, collect and process neuroimaging data, and to interpret their results. 3) To ensure trainees integrate multiple methods synergistically and carry out multi-modal neuroimaging projects in their home institutes. Our proposed program will train researchers for adequate handling of the increasing complexity of combining multimodal neuroimaging data with the knowledge of various data acquisition and processing approaches, and appropriate interpretations. This will speed up the synergistic application of multiple imaging modalities to basic and clinical neuroscience research in animals and humans.