Neurodevelopmental Origins of Emotion Dysregulation in Borderline Personality

边缘人格情绪失调的神经发育起源

• 批准号: 8507906
• 负责人: Michael Nelson Hallquist
• 金额: $ 15.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8507906
• 关键词: Adolescence; Adolescent; Adult; Age; Aggressive behavior; Amygdaloid structure; Anterior; Award; Behavior; Behavioral; Borderline Personality Disorder; Brain; Brain imaging; Brain region; Chronic; Clinical; Clinical assessments; Cognitive; Complex; Conflict (Psychology); Control Groups; Corpus striatum structure; Data; Development; Diagnostic; Disease; Disease remission; Dopamine; Emotional; Emotions; Equilibrium; Face; Fiber; Functional Magnetic Resonance Imaging; Fusiform gyrus; Impairment; Impulsive Behavior; Impulsivity; Incentives; Individual; Inpatients; Laboratories; Lateral; Lead; Link; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentors; Methods; National Institute of Mental Health; Neurobiology; Neurocognitive; Neurosciences; Outcome; Outpatients; Participant; Pathway interactions; Patients; Performance; Personality; Population; Prefrontal Cortex; Prevalence; Prevention program; Process; Psychopathology; Psychophysiology; Public Health; Quality of life; Regulation; Relative (related person); Research; Research Activity; Research Personnel; Research Priority; Research Training; Rewards; Risk; Role; Self-Injurious Behavior; Severities; Substance abuse problem; Suicide attempt; Symptoms; System; Teenagers; Testing; Time; Training; Training Activity; Treatment Cost; Ventral Striatum; base; career; cingulate cortex; cognitive control; disorder control; early adolescence; emerging adult; emotion regulation; experience; follow-up; improved; mesolimbic system; negative emotional state; neurobehavioral; neurodevelopment; novel; pleasure; prospective; public health relevance; relating to nervous system; suicidal; treatment program; young adult

DESCRIPTION (provided by applicant): The aim of this Mentored Research Scientist Development Award is to facilitate the candidate's development into a successful clinical neuroscience researcher investigating the neurodevelopmental basis of borderline personality disorder (BPD), particularly the role of adolescent maturation of cognitive and emotional control processes. Emotion dysregulation and impulsivity are prototypic features of BPD that typically emerge during adolescence and are associated with the persistence of BPD-related impairment over time. The immediate research priority of the proposed K01 award is to test the hypothesis that the development of these BPD symptoms in adolescence reflects dysfunctional adolescent maturation of connections among striatal, limbic, and prefrontal brain regions that support approach, avoidance, and modulatory neurobehavioral systems, respectively. The candidate has expertise in several domains relevant to studying the developmental psychopathology of BPD, including 1) the assessment of cognitive and emotion control processes using laboratory paradigms, 2) the behavioral and psychophysiological links between control processes and emotion dysregulation, and 3) the use of longitudinal data analytic methods to characterize developmental trajectories in BPD. To build upon this expertise and to focus specifically on the neural basis of BPD, the candidate will obtain further training in 1) developmental neuroscience approaches to the study of self-regulatory processes, 2) developmental psychopathology of BPD, and 3) functional and effective connectivity analyses to elucidate developmental changes in interregional connectivity during adolescence. Proposed research and training activities will be supported by the Laboratory of Neurocognitive Development directed by Dr. Beatriz Luna (primary mentor for this award), a noted developmental neuroscientist whose research has focused primarily on the protracted maturation of reward and control processes during adolescence. During the award, the candidate will conduct an fMRI study to characterize the maturation of interregional connectivity among the subgenual anterior cingulate cortex, ventral striatum, and amygdala during adolescence and early adulthood in healthy controls and individuals with BPD symptoms. Using functional and effective connectivity analyses, this study will characterize the balance of limbic-prefrontal and striatal- prefrontal influence during an emotion conflict task. The proposed research will also explore the prospective relationship between fronto-striatal-limbic connectivity and the developmental trajectory of BPD symptoms over an 18-month follow-up period. Consistent with the priorities of the National Institute of Mental Health, the proposed award has the potential to identify critical risk windows in the development of BPD using novel neurobiological methods. Further, the proposed award will provide the training and research experiences that will propel the candidate into a successful research career studying the neurodevelopment of BPD.

描述(由申请者提供)：这个指导式研究科学家发展奖的目的是促进候选人发展成为一名成功的临床神经科学研究人员，研究边缘性人格障碍(BPD)的神经发展基础，特别是青少年成熟的认知和情绪控制过程的作用。情绪失调和冲动是BPD的典型特征，通常出现在青春期，并与随着时间的推移BPD相关损害的持久性有关。建议的K01奖项的直接研究重点是测试一种假设，即这些BPD症状在青春期的发展反映了青春期纹状体、边缘和前额叶脑区域之间分别支持接近、回避和调节神经行为系统的连接功能障碍的成熟。该候选人在与BPD的发展精神病理学相关的几个领域拥有专业知识，包括1)使用实验室范例评估认知和情绪控制过程，2)控制过程和情绪失调之间的行为和心理生理联系，以及3)使用纵向数据分析方法来描述BPD的发展轨迹。为了加强这方面的专业知识，并特别关注BPD的神经基础，候选人将接受以下方面的进一步培训：1)研究自我调节过程的发展神经科学方法，2)BPD的发展精神病理学，以及3)功能和有效的连通性分析，以阐明青春期区域间连通性的发育变化。拟议的研究和培训活动将由Betriz露娜博士(该奖项的主要导师)领导的神经认知发展实验室提供支持，他是一位著名的发展神经科学家，他的研究主要集中在青春期奖励和控制过程的长期成熟上。在获奖期间，候选人将进行一项fMRI研究，以表征健康对照组和有BPD症状的个人在青春期和成年期早期亚性前扣带回皮质、腹侧纹状体和杏仁核之间的区域间连接成熟情况。本研究将运用功能和有效的连通性分析，来表征情绪冲突任务中边缘-前额叶和纹状体-前额叶影响的平衡。这项拟议的研究还将在18个月的随访期内探索额叶-纹状体-边缘连接与BPD症状发展轨迹之间的预期关系。与国家精神卫生研究所的优先事项一致，拟议的奖项有可能确定使用新的神经生物学方法发展BPD的关键风险窗口。此外，拟议的奖项将提供培训和研究经验，推动候选人进入研究BPD神经发育的成功研究生涯。