Simplifying fMRI Integration in the Cognitive Neurosciences

简化认知神经科学中的功能磁共振成像集成

• 批准号: 8455897
• 负责人: Bruno C Tagliaferri
• 金额: $ 15万
• 依托单位: PERCEPTION RESEARCH SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8455897
• 关键词: Administrator; Adoption; Area; Basic Biobehavioral Research; Behavior Control; Behavioral; Brain; Clinical Trials; Code; Cognition; Collection; Communication; Computer software; Development; Devices; Disease; Equipment; Failure; Feedback; Functional Magnetic Resonance Imaging; Glues; Growth; Health; Human; Image; Interview; Investments; Linux; Measures; Modality; Neurosciences; Neurosciences Research; Phase; Physiologic pulse; Research; Research Infrastructure; Research Personnel; Resources; Running; Series; Signal Transduction; Site; Solutions; Staging; Stimulus; System; Systems Integration; Techniques; Technology; Testing; Time; Training; Translating; Translational Research; analog; base; clinical practice; cognitive neuroscience; design; flexibility; millisecond; neurobehavioral; programs; prototype; public health relevance; radiologist; relating to nervous system; research study; response; translational study; visual stimulus; wasting

DESCRIPTION (provided by applicant): Over the last two decades, fMRI has evolved into a widely used technology in basic biobehavioral research. The user base for this technology continues to increase due to the growth of the field of cognitive neuroscience, and this increase is poised to accelerate with adoption of fMRI to large-scale multi-site studies, translational studies, and clinical trials. In order to observe functionally relevant neural responses, it is necessary to conduct experiments in which brain activity is measured while audio/visual stimuli are presented, and behavioral responses are recorded. Further, the software controlling these behavioral experiments must be carefully synchronized with the functioning of the MR scanner itself. Thus, building capacity for fMRI research involves a massive investment in infrastructure for specialized hardware for audio/visual stimulus presentation, behavioral response recording and synchronization of these devices with the MR equipment. And yet, the critical interface between this infrastructure and the software that controls the behavioral experiments, that are the core of the functional assessments in fMRI, is often ad hoc, complicated to use and prone to failure. This creates time-consuming and expensive difficulties at multiple stages of the development and execution of studies, and creates a set of technical problems that are outside the core capabilities and training of the physicists, radiologists and technicians responsible for managing, running and maintaining the MR center. We propose to create a universal software/hardware interface that will dramatically streamline the development and implementation of studies at existing fMRI research sites. The device will provide a sturdy, fixed, standardized, flexible and intuitive interface between a wide variety of experimental control software and all widely used MR systems. Once a minimal viable product is developed, we will test its efficacy in an active fMRI research center.

描述（由申请人提供）：在过去的二十年中，fMRI已经发展成为基础生物行为研究中广泛使用的技术。由于认知神经科学领域的发展，该技术的用户群持续增加，并且随着fMRI用于大规模多站点研究、转化研究和临床试验，这种增加有望加速。为了观察功能相关的神经反应，有必要进行实验，其中在呈现音频/视觉刺激的同时测量大脑活动，并记录行为反应。此外，控制这些行为实验的软件必须与MR扫描仪本身的功能仔细同步。因此，功能磁共振成像研究能力的建设涉及到大量投资的基础设施，专门的硬件音频/视觉刺激的介绍，行为反应记录和这些设备与磁共振设备的同步。然而，这个基础设施和控制行为实验的软件之间的关键接口，是功能磁共振成像功能评估的核心，通常是临时的，使用起来很复杂，而且容易失败。这在研究的开发和执行的多个阶段造成了耗时和昂贵的困难，并产生了一系列技术问题，这些问题超出了负责管理、运行和维护MR中心的物理学家、放射科医生和技术人员的核心能力和培训范围。我们建议创建一个通用的软件/硬件接口，将大大简化现有的功能磁共振成像研究站点的研究的开发和实施。该装置将提供一个坚固、固定、 在各种实验控制软件和所有广泛使用的MR系统之间提供标准化、灵活和直观的接口。一旦开发出最小可行产品，我们将在一个活跃的功能磁共振成像研究中心测试其功效。