Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)

LSTM与CDC的机构合作及疟疾预防(U01)

• 批准号: 8711024
• 负责人: FEIKO OLAF TER KUILE
• 金额: $ 92.55万
• 依托单位: TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711024
• 关键词: Institutional; Collaboration; between; LSTM; CDC

DESCRIPTION (provided by applicant): This proposal outlines continued collaboration between the Malaria Branch of the Centers for Disease Control and Prevention (CDC) and the Malaria Epidemiology Section of the Liverpool School of Tropical Medicine (LSTM) to support CDC partners in malaria endemic countries in the conduct of collaborative research to improve the control of malaria in Africa and in Indonesia and to coordinate international research initiatives for malaria control. LSTM, on behalf of the Malaria in Pregnancy (MiP) Consortium, will coordinate research strategy development between CDC and other International partners in Europe, Australia and endemic countries for future studies of the control of malaria in pregnancy. In addition, a range of research projects will be conducted jointly between LSTM, CDC and the overseas partners of CDC in Indonesia (the Eijkman Institute, Jakarta) and in western Kenya (KEMRI-CDC field station). These fall under three main objectives: malaria control; malaria in pregnancy; and integrated disease control, following the outline of the original call. Several projects start in year 1 and reflect an extension of the joint activities as part of the existing cooperative agreement (CoAg) between LSTM and CDC's Malaria Branch. These include a study to develop tools to monitor antimalarial drug safety in early pregnancy and a survey to evaluate a new rapid assessment toolkit for the evaluation of access, delivery and use of interventions for malaria in pregnancy, both in western Kenya; the central coordination of a multi-country observational study in Africa to determine the effect of sulfadoxine-pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp) effectiveness, and two studies in Indonesia: a) a study evaluating the use of cell-phone technology to improve malaria surveillance by village based health-care workers in remote settings in Indonesia; b) evaluation of the performance of rapid diagnostic tests (RDTs) for the control of malaria in pregnancy in remote settings. In addition, grant proposals will be written in years 1 and 2 to generate research funds for the activities planned in years 2-5, including studies of integrated approaches to disease control which combine screening for HIV with scheduled screening for malaria, syphilis and anemia, and use of intermittent screening and treatment of malaria in pregnancy. During the course of the CoAg, LSTM will provide technical support to CDC as requested for specific pharmacokinetic studies in HIV- infected adults, in children (age-based dosing) and in pregnant women (Mefloquine). Lastly, the activities include formal PhD training of individuals and short-term training in clinical trial methodology. LSTM will also continue to provide technical advice to the World Health Organization (WHO) and Roll Back Malaria (RBM) in support of scaling up of malaria control interventions globally.

描述（申请人提供）：该提案概述了疾病控制和预防中心（CDC）疟疾分支与利物浦热带医学院（LSTM）疟疾流行病学部门之间的持续合作支持疟疾流行国家的CDC合作伙伴开展合作研究，以改善非洲和印度尼西亚的疟疾控制，并协调国际研究活动来控制疟疾。LSTM代表妊娠期疟疾（MiP）联盟，将协调CDC与欧洲，澳大利亚和流行国家的其他国际合作伙伴之间的研究战略发展，以促进妊娠期疟疾控制的未来研究。此外，LSTM、CDC和CDC在印度尼西亚（雅加达Eijkman研究所）和肯尼亚西部（KEMRI-CDC现场站）的海外合作伙伴将联合开展一系列研究项目。这些目标分为三个主要目标：疟疾控制;妊娠期疟疾;以及按照最初呼吁的大纲进行的综合疾病控制。有几个项目从第一年开始，反映了LSTM和CDC疟疾分支之间现有合作协议（CoAg）的一部分联合活动的扩展。其中包括在肯尼亚西部开展一项研究，以开发工具来监测怀孕早期抗疟药物的安全性，并开展一项调查，以评价一个新的快速评估工具包，用于评估怀孕期间疟疾干预措施的获得、提供和使用情况;在非洲进行的一项多国观察性研究的中央协调，以确定磺胺嘧啶-乙胺嘧啶（SP）耐药性对妊娠期间歇性预防性治疗的影响（在印度尼西亚进行了两项研究：a）一项研究，评价在印度尼西亚偏远地区乡村保健工作者使用手机技术改进疟疾监测的情况; B）评价在偏远地区控制妊娠期疟疾的快速诊断测试的性能。此外，将在第一年和第二年提出赠款建议，为第二至第五年计划的活动筹集研究资金，包括研究疾病控制的综合办法，这种办法将艾滋病毒联合收割机检查与疟疾、梅毒和贫血的定期检查结合起来，并在怀孕期间使用间歇性检查和治疗疟疾。在CoAg期间，LSTM将根据要求为CDC提供技术支持，用于在HIV感染的成人、儿童（基于年龄的给药）和孕妇（甲氟喹）中进行特定的药代动力学研究。最后，这些活动包括个人的正式博士培训和临床试验方法的短期培训。LSTM还将继续为世界卫生组织（WHO）和减少疟疾（RBM）提供技术咨询，以支持在全球范围内扩大疟疾控制干预措施。