Institutional Research Collaboration between the Liverpool School of Tropical Medicine and the Centers for Department of Health and Human Services Centers for Disease Control and Prevention

项目摘要 这是疾病预防控制中心疟疾分支与 利物浦热带医学院（LSTM）。建议的研究策略如下： FOA中概述的目标，涉及4个主题：a）与以下方面有关的业务研究（OR） 减少疟疾传播，B）或确定新的或改进的儿童干预措施 c）最大限度地扩大对公共卫生的影响 支持将控制妊娠期疟疾的全球政策转化为国家政策， （d）通过信息交流，加强国家一级的研究能力（3.1） 肯尼亚，马拉维和印度尼西亚的海外合作伙伴通过提供个人水平的博士学位 以及博士后研究生和小组课程（5.1）。减少疟疾传播或 这些活动是在肯尼亚与联合国之间长期合作的框架下进行的。 肯尼亚医学研究所（KEMRI）和疾病预防控制中心。LSTM将与CDC合作， 向肯尼亚环境研究所提供技术支持，以建立追踪疟疾所需的信息基础设施 传播强度和实现疟疾控制目标的进展情况， 发展大规模昆虫监测系统， 病媒密度、户外叮咬增加和病媒对常用的 杀虫剂（1.1），支持发展强化的半自动化例行监测 建立具有可扫描登记册的系统，并进行连续的疟疾指标调查，以进行真实的- 病例负担和感染流行率的时间监测（4.1）。LSTM将支持CDC， 开发概念并寻求资金用于确定安全性的原理验证研究， 大规模药物与抗疟药联合给药的可行性和有效性 室内滞留喷洒（2.1）。它将支持伯氨喹的剂量探索研究， 伊维菌素，旨在确定辅助疗法，以提高大规模药物的影响， 管理（MDA）（2.2），并支持不同干预措施的经济评估 作为减少传播活动一部分的监测方法（2.3）。高等教育研究 风险群体包括研究如何提高对疟疾病例管理指南的遵守 在肯尼亚西部的妊娠期（1.2）和三个大型多中心试验，包括一个关于 通过出院后疟疾化学预防来预防反弹入院和死亡 肯尼亚严重贫血症儿童的研究（2.4）和两项关于控制妊娠期疟疾的研究： STOPMIP-印度尼西亚（2.6），STOPMIP 2在肯尼亚和马拉维（2.5），评价安全性和 双氢青蒿素-哌喹间歇预防性治疗疗效观察

Project summary This is the 3rd, 5-year collaborative agreement between CDC's Malaria Branch and the Liverpool School of Tropical Medicine (LSTM). The proposed research strategy follows the objectives outlined in the FOA and involves 4 themes: a) Operational research (OR) related to malaria transmission reduction, b) OR to identify novel or improved interventions for children with severe malarial anaemia and pregnant women, c) Maximising the public health impact by supporting translation of global policies for the control of malaria in pregnancy to country level policies through information exchange (3.1), and d) Strengthening research capacity of the overseas partners in Kenya, Malawi and Indonesia by provision of individual level PhD and post-doctoral studentships and group courses (5.1). Malaria transmission reduction OR activities take place under the umbrella of the long-term collaboration between the Kenya Medical Research Institute (KEMRI) and CDC in Kenya. LSTM will work with CDC to provide technical support to KEMRI to build the information infrastructure needed to track malaria transmission intensity and progress towards malaria control targets, including the rational development of large-scale entomological monitoring systems in situations with declining vector densities, increased outdoor biting and vector resistance to the commonly used insecticides (1.1), support the development of enhanced semi-automated routine surveillance systems with scannable registers, and conduct continuous malaria indicator surveys for real- time monitoring of the case-burden and infection prevalence (4.1). LSTM will support CDC to develop the concept and seek funding for proof-of-principle studies that determine the safety, feasibility and effectiveness of mass-drug administration with antimalarials when combined with indoor residual spraying (2.1). It will support dose finding studies with primaquine and ivermectin that aim to identify adjunct therapies to enhance the impact of mass drug administration (MDA) (2.2), and support the economic evaluation of different interventions and surveillance methods as part of the transmission reduction activities (2.3). Studies in high risk groups includes research to improve adherence to malaria case-management guidelines in pregnancy in western Kenya (1.2) and three large multi-centre trials including one on the prevention of rebound admissions and deaths with post-discharge malaria chemoprevention in children with severe anaemia in Kenya (2.4) and two on the control of malaria in pregnancy: STOPMiP-Indonesia (2.6), STOPMIP2 in Kenya and Malawi (2.5) evaluating the safety and efficacy of intermittent preventive therapy with dihydroartemisinin-piperaquine.