Center for Cancer Signaling Networks

我们的III型过渡COBRE的主要目标是提供最先进的基因组和转基因核心 服务布朗大学社区和附属中心在东北部，同时准备 在未来五年内向独立支持过渡。该中心的科学主题与 II型COBRE支持的是癌症信号网络。这一科学主题将继续下去， 作为一个中心，我们准备为更广泛的科学项目提供研究基础设施， 最初在II型COBRE中得到支持。与第三类相关的试点项目机制 COBRE将被用于核心的教师群体的合作努力，重点是重要的科学 这些问题可以立即转化为多PI和/或程序项目应用程序。研究 最初提出的核心是小鼠转基因，成像，基因组学和生物信息学。前三 这是从COBRE I型结转的，而后者是作为一个新的核心设施建立的。的 生物信息学核心只是在II型COBRE演变为独立中心时得到了短暂的支持 （Center for Computational Molecular Biology）成像核心也从COBRE支持中毕业 现在作为一个独立的机构运作。成像核心呈指数级增长， 布朗和该州的调查人员的资源。我们有使用COBRE资源的记录， 发展坚实的研究核心，其科学重点使他们能够实现独立， 机制我们正在请求支持的剩余两个核心正在迅速增加 被罗得岛的科学界高度依赖。我们将继续改进这些核心 他们可以独立地由用户费、个人和 项目类型的赠款支持，以及必要时的大学费用分摊。

The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent suport in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed.