CENTER FOR CANCER SIGNALING NETWORKS

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心赠款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：我们的III型过渡COBRE的主要目标是为布朗大学社区和东北部的附属中心提供最先进的基因组和转基因核心服务，同时准备在未来五年内过渡到独立支持。该中心在II型COBRE支持下开发的科学主题是癌症信号网络。这个一般的科学主题将继续下去，但我们作为一个中心，准备为更广泛的科学项目提供研究基础设施，而不是最初在II型COBRE中支持的。与III型COBRE相关的试点项目机制将用于促进教师团队的合作，重点关注可以立即转化为多PI和/或项目应用程序的重大科学问题。最初提出的研究核心是小鼠转基因，成像，基因组学和生物信息学。前三个是从COBRE I型转移过来的，而后者是作为一个新的核心设施建立的。生物信息学核心只是在II型COBRE发展成为一个独立的中心（计算分子生物学中心）时得到了短暂的支持。成像核心也从COBRE支持中毕业，现在作为一个独立的设施运作。成像核心呈指数级增长，是布朗和该州调查人员的主要资源。我们有使用COBRE资源开发坚实的研究核心的记录，其科学重点使他们能够独立于这种机制。我们剩下的两个核心，我们正在请求支持，正在迅速成为越来越多的依赖于科学界在罗得岛这里。我们将继续改进这些核心，使其能够在需要时通过用户费用、个人和项目类型的赠款支持以及大学分摊成本的组合来独立支持。 公共卫生相关性（由申请人提供）：本申请中提出的研究资源将促进布朗及其在罗得岛州的附属机构开展广泛的癌症相关研究项目。在基因组学和转基因的最先进的核心设施的状态是至关重要的，以保持我们在科学界的卓越地位。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent support in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed. PUBLIC HEALTH RELEVANCE (provided by applicant): The research resources that are proposed in this application will foster a broad range of cancer related research programs at Brown and its affiliates in the State of Rhode Island. The state of the art core facilities in genomics and transgenics are critical to maintaining our position of excellence in the scientific community.