CENTER FOR CANCER SIGNALING NETWORKS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 描述(申请人提供)：我们III型过渡中心的主要目标是为东北的布朗大学社区和附属中心提供最先进的基因组和转基因核心服务，同时准备在未来五年过渡到独立的支持。在第二类Cobre的支持下开发的该中心的科学主题是癌症信号网络。这一总的科学主题将继续下去，但我们作为一个中心，准备为比第二类眼镜蛇最初支持的更广泛的科学项目提供研究基础设施。与类型III Cobre相关的试点项目机制将被用来促进教师小组的合作努力，这些教师小组专注于重要的科学问题，这些问题可以立即转化为多PI和/或计划项目应用。最初提出的研究核心是小鼠转基因、成像、基因组学和生物信息学。前三个是从第一类科布雷延续下来的，而后者是作为新的核心设施而建立的。生物信息学核心只得到了第二类科布雷的短暂支持，因为它演变成了一个独立的中心(计算分子生物学中心)。成像核心也是从Cobre Support毕业的，现在是一个独立的设施。成像核心呈指数级增长，是布朗和该州调查人员的主要资源。我们有利用Cobre资源开发可靠研究核心的记录，这些核心的科学重点使它们能够实现对这一机制的独立。我们正在请求支持的其余两个核心迅速变得更加依赖于罗德岛这里的科学界。我们将继续改进这些核心，以便在需要时可以通过用户费用、个人和项目类型的赠款支持以及大学费用分担来独立支持这些核心。 公共卫生相关性(由申请人提供)：本申请中建议的研究资源将促进布朗及其在罗德岛州的附属机构开展广泛的癌症相关研究项目。基因组学和转基因方面最先进的核心设施对于保持我们在科学界的卓越地位至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent support in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed. PUBLIC HEALTH RELEVANCE (provided by applicant): The research resources that are proposed in this application will foster a broad range of cancer related research programs at Brown and its affiliates in the State of Rhode Island. The state of the art core facilities in genomics and transgenics are critical to maintaining our position of excellence in the scientific community.