Structural requirements for immunostimulation by plant lipids
植物脂质免疫刺激的结构要求
基本信息
- 批准号:8500370
- 负责人:
- 金额:$ 10.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-13 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcademyAcquired Immunodeficiency SyndromeAnimal ModelApplications GrantsAsiansBiological AssayBiological FactorsCancer PatientCellsChemicalsChemistryCore FacilityDataDevelopmentDiamondDrug FormulationsElementsEvaluationFatty AcidsGlycosidesGoalsGrantGroup MeetingsHeadHerbal MedicineImmuneImmune systemImmunizationImmunologic AdjuvantsImmunologyInvestigationJapanJournalsLabelLengthLibrariesLipidsManuscriptsMedicalMetabolicMinorityMolecularMolecular ProbesNational Center for Complementary and Alternative MedicineNational Institute of Allergy and Infectious DiseaseNational Institute of General Medical SciencesNatural Products ChemistryNeutropeniaNew YorkOutcomePaperPatternPharmaceutical ChemistryPharmaceutical PreparationsPlantsPublicationsQuality of lifeRadiation therapyRadioisotopesRecombinant Granulocyte Colony Stimulating FactorResearchResearch PersonnelResearch Project GrantsSafetySamplingScienceSecureSeriesStagingStructureStructure-Activity RelationshipTherapeuticToxic effectUniversitiesWritingacyl groupanalogbasecancer immunotherapycancer therapychemotherapycollegedesigndrug developmentimprovedin vivoinnovationlipoteichoic acidmeetingsnovelpharmacophoreprogramspublic health relevancescreeningsmall moleculestereochemistrysymposiumtherapeutic evaluation
项目摘要
DESCRIPTION (provided by applicant): Chemotherapy and radiotherapy cause severe damages to the immune system of cancer patients. Although chemotherapy-induced neutropenia can be alleviated with recombinant granulocyte colony-stimulating factor, therapeutic options to treat damages caused by standard cancer therapy are limited, which underscores the importance of the development of new drugs to improve the quality of life (QOL) of cancer patients. Our recent study indicates that a series of diacylglyceryl glycosides (DGGs) are potent immunostimulants in an oriental herbal formulation called Juzen-taiho-to (JTT), which is clinically used to rebuild the immune system of cancer patients in Japan. The proposed study has two aims; namely, (i) structural elucidation of the series of DGGs in JTT and characterization of the structure-activity relationship of these compounds. Once the structural requirements for the immunostimulation by DGGs are clarified, it would become possible to fully explore their therapeutic potential with rationally designed new immunostimulants based on the simple DGG framework. The proposed research, therefore, opens an exciting possibility that QOL of cancer patients can be improved with a cocktail of chemically defined, orally available small molecules.
描述(申请人提供):化疗和放疗对癌症患者的免疫系统造成严重损害。虽然化疗诱导的中性粒细胞减少症可以用重组粒细胞集落刺激因子缓解,但治疗标准癌症治疗引起的损害的治疗选择是有限的,这强调了开发新药以改善癌症患者生活质量(QOL)的重要性。我们最近的研究表明,一系列的二酰基甘油苷(DGG)是有效的免疫刺激剂的东方草药配方称为Juzen-taiho-to(JTT),这是临床上用于重建癌症患者的免疫系统在日本。该研究有两个目的,即(i)JTT中一系列DGG的结构解析和这些化合物的构效关系表征。一旦阐明了DGG免疫刺激的结构要求,就有可能通过基于简单DGG框架合理设计的新免疫刺激剂来充分探索其治疗潜力。因此,拟议的研究开启了一种令人兴奋的可能性,即癌症患者的QOL可以通过化学定义的口服小分子鸡尾酒来改善。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AKIRA KAWAMURA其他文献
AKIRA KAWAMURA的其他文献
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{{ truncateString('AKIRA KAWAMURA', 18)}}的其他基金
Phytobacterial lipopolysaccharides in Juzen-taiho-to
十善太凤堂中的植物细菌脂多糖
- 批准号:
10686871 - 财政年份:2020
- 资助金额:
$ 10.89万 - 项目类别:
Phytobacterial lipopolysaccharides in Juzen-taiho-to
十善太凤堂中的植物细菌脂多糖
- 批准号:
10466915 - 财政年份:2020
- 资助金额:
$ 10.89万 - 项目类别:
Phytobacterial lipopolysaccharides in Juzen-taiho-to
十善太凤堂中的植物细菌脂多糖
- 批准号:
10263143 - 财政年份:2020
- 资助金额:
$ 10.89万 - 项目类别:
Structural requirements for immunostimulation by plant lipids
植物脂质免疫刺激的结构要求
- 批准号:
8126345 - 财政年份:2010
- 资助金额:
$ 10.89万 - 项目类别:
Structural requirements for immunostimulation by plant lipids
植物脂质免疫刺激的结构要求
- 批准号:
8289478 - 财政年份:2010
- 资助金额:
$ 10.89万 - 项目类别:
Structural requirements for immunostimulation by plant lipids
植物脂质免疫刺激的结构要求
- 批准号:
7939467 - 财政年份:2010
- 资助金额:
$ 10.89万 - 项目类别:
GENOMIC SCREENING OF TOHKI-SHAKUYAKU-SAN
TOHKI-SHAKUYAKU-SAN 的基因组筛选
- 批准号:
7164278 - 财政年份:2005
- 资助金额:
$ 10.89万 - 项目类别:
Genomic Screening of Kampo Herbal Medicine (pilot)
汉方药材基因组筛选(试点)
- 批准号:
6773135 - 财政年份:2004
- 资助金额:
$ 10.89万 - 项目类别:
GENOMIC SCREENING OF TOHKI-SHAKUYAKU-SAN
TOHKI-SHAKUYAKU-SAN 的基因组筛选
- 批准号:
7011406 - 财政年份:2004
- 资助金额:
$ 10.89万 - 项目类别:
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