Maternal Arousal Preterm Birth

孕产妇性唤起早产

• 批准号: 8366727
• 负责人: DEBORAH KIM
• 金额: $ 20.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-06 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366727
• 关键词: Acoustics; Adrenal Glands; Affect; Affective; Age; Anxiety; Anxiety Disorders; Arousal; Behavioral; Biologic Development; Brain; Child; Childhood; Corticotropin-Releasing Hormone; Development; Disease; Dose; Emotional; Endocrine; Environment; Event; Female; Fetus; Future; Generations; Genes; Genetic; Gestational Age; Gonadal Steroid Hormones; Health; Hormonal; Hormones; Human; Hydrocortisone; Individual; Infant; Instruction; Laboratories; Life; Link; Longevity; Low Birth Weight Infant; Measures; Mental Depression; Mental disorders; Modeling; Mood Disorders; Mothers; Neurosecretory Systems; Onset of illness; Outcome; Parenting behavior; Physiological; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Premature Birth; Prevalence; Process; Production; Psychophysiology; Puberty; Questionnaires; Recording of previous events; Regulation; Risk; Risk Marker; Salivary; Serotonin; Severities; Sex Bias; Sex Characteristics; Stimulus; Stress; System; Time; Translating; Trauma; Woman; adverse outcome; base; critical period; disorder risk; effective intervention; experience; fetal; fetal programming; gene environment interaction; hypothalamic-pituitary-adrenal axis; in utero; infant outcome; male; maternal stress; offspring; prenatal experience; prepuberty; programs; reproductive; response; stressor; transmission process

Pregnancy is a unique period in a woman's emotional life, as she becomes a mother and reflects upon her own parenting and experience as a child. Pregnancy is also a unique period in a woman's endocrine life when sex steroids are at 10- to 100- fold their nonpregnancy levels and stress hormones are surging. In fact, at no other time in human life are both corticotropin releasing factor (CRF) and Cortisol persistently elevated as the placental production of CRF is positively driven by maternal and fetal Cortisol production. Project I serves as the initial segment of the lifespan approach to understanding the effects of prepubertal adversity on brain function as it relates to risk for affective disorders (depression and anxiety) in women. In this project we evaluate a two-generational model of stress by examining the effect of maternal prepubertal adversity on the progeny's health as a way to understand the earliest environmental influence on the biologic development of their offspring. We hypothesize that the effects of maternal past and present experience can be 'transmitted' to the fetus via the exceptional hormonal milieu of the intrauterine environment, programming the offspring's own response to future life events through HPA axis dysregulation. We propose that female infants will be more susceptible to fetal programming than male infants as one explanatory factor for increased prevalence of depression in females compared to males. This project examines maternal and infant HPA axis function and utilizes the well-tolerated acoustic startle paradigm to explore the potential link beh/veen maternal prepubertal adversity and the following outcomes; 1) maternal HPA axis responsivity; 2) maternal psychophysiology, at baseline and in response to affect modulation; 3) infant behavioral and HPA axis response to stress; and 4) sex difference in infant outcomes. In addition, this project will serve as the basis for future exploration of the potential interaction between prepubertal adversity and serotonin and stress system genes in the sex bias for MDD and other disorders for which sex differences have been noted.

怀孕是女人的情感生活中的独特时期，因为她成为母亲并反思她 自己小时候的育儿和经验。怀孕也是女性内分泌生活的独特时期 当性类固醇处于10至100倍时，其非怀孕水平且应力激素在飙升。在 事实，人类生活中的其他时间既是皮质激素释放因子（CRF），又是皮质醇 由于CRF的胎盘生产而升高是由母体和胎儿皮质醇产生的积极驱动的。 我作为生命周期方法的初始部分来理解青春期前的效果 脑部功能的逆境与女性情感障碍（抑郁和焦虑）的风险有关。在 该项目我们通过检查母体青春期前的效果来评估两代压力模型 对后代健康的逆境是一种了解最早对生物学的环境影响的一种方式 他们后代的发展。我们假设母亲过去和现在的经验的影响可以 通过宫内环境的特殊荷尔蒙环境“传播”到胎儿，编程 后代通过HPA轴的失调对未来生活事件的反应。我们建议那个女性 婴儿将比男性婴儿更容易受到胎儿编程的影响。 与男性相比，女性抑郁症患病率增加。该项目检查了母亲和 婴儿HPA轴功能，并利用富裕的声学惊吓范式探索潜在的链接 Beh/veen孕产妇青春期前逆境和以下结果； 1）母体HPA轴反应性； 2） 孕产妇心理生理学，基线时，以应对调制； 3）婴儿行为和HPA 轴对压力的响应； 4）婴儿结局的性别差异。此外，该项目将作为 将来探索青春期前逆境与5-羟色胺和5-羟色胺和 在性别偏见的MDD和其他性别差异的其他疾病中，应力系统基因已被注意到。