Neuroimaging Core Facility

神经成像核心负责优化和更新神经成像方案；对CBDB神经成像研究人员收集的所有结构MRI、功能MRI、磁共振波谱和DTI数据进行维护、监测、分析和进行质量控制筛选。总的来说，神经成像核心实验室继续涵盖以下神经成像领域： 1.结构磁共振成像：采集、质量控制、分割、自动和手动感兴趣区域(ROI)定义和测量、表面提取； 2.功能磁共振成像：采集、质量控制、前处理、标准化分析； 3.光谱学：采集、质量控制、预处理、基于感兴趣区和体素； 4.DTI：获取、质量控制、预处理；以及 5.实施新的磁共振成像技术 为了实现这些目标，神经成像核心继续提供以下服务： 1.医疗覆盖和图像采集、图像质量控制(针对核心采集的数据)； 2.刺激设备的维护，与其他NIH成像核心设施的联系； 3.实施和维持生理测量和干预措施的获取(例如皮肤电反应、瞳孔测量、脉压、孔内脑电/经颅电波)； 4.编制和更新MR采集和数据分析方法手册； 5.培训和监督研究助理和研究员有关神经成像方法和分析的知识； 6.进行标准化分析和分析质量控制；以及 7.将原始和处理后的数据建立数据库并分发给CBDB和调查人员；与CBDB内维护的基因组数据和其他科学数据相结合 为了提供这些服务，核心需要几名专职医生、神经科学家、计算机专家和相当大的研究助理小组(至少7人，分为功能结构光谱/DTI小组)的参与，他们在成像和图像分析之间轮换。所有这些人都接受了培训，以保持在成像和分析方面的标准知识水平。 此外，为了便于管理大规模神经成像遗传学研究所需的非常高吞吐量的多模式成像数据集，该小组成员创建了一个神经成像数据库(XNatGCAP改编自XNAT(可扩展神经成像档案工具包，BIRN赞助的项目)的早期版本)。该数据库允许以高效和精确的方式管理大量数据，并为管理和优化神经成像数据的数据归档、数据识别、数据处理、结果检查、数据共享和数据挖掘而定制。它以最小的管理开销，以安全的方式促进调查人员之间的协作研究。

The Neuroimaging Core has been responsible for optimizing and updating neuroimaging protocols; maintaining, monitoring analyzing and conducting quality control screening of all structural MRI, functional MRI, MR spectroscopy, and DTI data collected by CBDB neuroimaging investigators. In general, the Neuroimaging Core lab continues to cover the following neuroimaging domains: 1. Structural MRI: acquisition, quality control, segmentation, automated and manual regions-of-interest (ROI) definition and measurements, surface extraction; 2. Functional MRI: acquisition, quality control, preprocessing, standardized analyses; 3. Spectroscopy: acquisition, quality control, preprocessing, ROI-based and voxel-based; 4. DTI: acquisition, quality control, preprocessing; and 5. Implementing new MRI techniques To meet these goals, the Neuroimaging Core continues to provide the following services: 1. Medical coverage and image acquisition, image quality control (for data acquired by the core); 2. Maintenance of stimulation equipment, liaison with other NIH imaging core facilities; 3. Implement and maintain acquisition of physiological measurements and interventions, (e.g. galvanic skin response, pupillometry, pulse pressure, in-bore EEG/TMS); 4. Created and update a manual of MR acquisition and data analysis methods; 5. Train and supervise research assistants and fellows in neuroimaging methods and analysis; 6. Perform standardized analyses and analysis quality control; and 7. Databasing and distribution of raw and processed data to CBDB and investigators; integration with genomic and other scientific data maintained within CBDB To provide these services, the core requires the participation of several staff physicians, neuroscientists, computer specialists, and a fairly large group of research assistants (at a minimum 7, divided into function-structural-spectroscopy/DTI groups) who rotate between imaging and image analyses. All these individuals have been trained to maintain a standard level of knowledge in imaging and analysis. In addition, to facilitate the management of the very high throughput of multimodal imaging datasets necessary for large scale neuroimaging genetic studies, members of the group have created a neuroimaging database (XNATGCAP adapted from the early version of XNAT (The Extensible Neuroimaging Archive Toolkit, a BIRN sponsored project). This database allows management of large amounts of data in an efficient and precise manner and is customized to manage and optimize data archiving, data de-identification, data processing, results inspection, data sharing and data mining of neuroimaging data. It facilitates collaborative research across investigators in a secure manner with minimum management overhead.